(+)-N,N'-(1S,2S)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE)

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Product Name: (+)-N,N'-(1S,2S)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE)
CAS No.: 172138-95-3
Chemical Name: (+)-N,N'-(1S,2S)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE)
Synonyms: (S,S)-DACH-pyridyl Trost ligand;(S,S)-DACH-pyridyl Trost ligand 95%;2,6-Bis[(4S)-benzyl-2-oxazolin-2-yl]-pyridine;(1S,2S)-1,2-Bis(2-pyridinecarboxamido)cyclohexane;N,N'-((1S,2S)-Cyclohexane-1,2-diyl)dipicolinamide;N-((1S,2S)-2-(picolinamido)cyclohexyl)picolinamide;(1R,2R)-(-)-1,2-Bis[(2-pyridinylcarbonyl)amino]cyclohexane;2-Pyridinecarboxamide, N,N'-(1S,2S)-1,2-cyclohexanediylbis-;1S,2S- N,N’-1,2-Diaminocyclohexanediylbis (2-pyridinecarboxamide);(1S,2S)-N,N'-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide)
CBNumber: CB1119961
Molecular Formula: C18H20N4O2
Formula Weight: 324.38
MOL File: 172138-95-3.mol

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(+)-N,N'-(1S,2S)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE) Property

Melting point:: 170°C
Boiling point:: 663.4±50.0 °C(Predicted)
alpha: +95° (c 1, CH3OH)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
pka: 12.51±0.40(Predicted)
form: Powder
color: off-white
CAS DataBase Reference: 172138-95-3

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39-36/37
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Strem Chemicals

Product number: 07-0341
Product name: (+)-N,N'-(1S,2S)-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide), min. 98% (S,S)-DACH-Pyridyl Trost Ligand
Packaging: 1g
Price: $108
Updated: 2024/03/01

Strem Chemicals

Product number: 07-0341
Product name: (+)-N,N'-(1S,2S)-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide), min. 98% (S,S)-DACH-Pyridyl Trost Ligand
Packaging: 5g
Price: $427
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FD149625
Product name: (+)-N,N'-(1S,2S)-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide)
Packaging: 10g
Price: $522
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0004350
Product name: (+)-N,N'-(1S,2S)-1,2-DIAMINOCYCLO HEXANEDIYL BIS(2-PYRIDINE CARBOXAMIDE)
Purity: 95.00%
Packaging: 100MG
Price: $638.87
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD149625
Product name: (+)-N,N'-(1S,2S)-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide)
Packaging: 25g
Price: $1043.75
Updated: 2021/12/16

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(+)-N,N'-(1S,2S)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE) Chemical Properties,Usage,Production

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Ligands for Mo catalyzed asymmetric allylic substitutions. Especially useful for the synthesis of tertiary and quaternary stereocenters. Exclusive license for this technology acquired by ChiroTech and is protected by pending Stanford University patents.
Dynamic kinetic asymmetric formation of tertiary and quaternary stereogenic centers

Uses

Trost Ligands for Asymmetric Allylic Alkylation

Synthesis

1,1'-Carbonyldiimidazole (1.7Kg, 10.48mol) and THF (7.5L) were added to a 22L flask and solid pyridinecarboxylic acid (1.36Kg, 11 mol) was added to the slurry at room temperature, the reaction was heat absorbed and the mixture was allowed to cool down from 18??C to 12??C, then the reaction mixture was heated to 18-19??C. The resulting clarified solution was stirred for 1 h and (1S,2S)-(+)-1,2-diaminocyclohexane (0.5 Kg, 4.38 mol) was added within 1 h while keeping the temperature lower than 50 ??C, the beaker and funnel were rinsed with 2.5 L of THF, the reaction was stirred at room temperature for 15 h. Water (0.5 L) was added to the dilute slurry to obtain a clarified solution and the reaction mixture was The reaction mixture was stirred for 1 h. The reaction mixture was concentrated to an orange semi-solid by rotary evaporation, and the reaction product was slurried in 5 L of ethanol and concentrated by rotary evaporation, dissolved in ethanol (5 L) at 64-65 ??C, cooled, and the solution became turbid at about 58 ??C. The turbid solution was inoculated (10 g) at this temperature and cooled to -8??C. The resulting white crystals were separated by filtration over a sintered glass funnel and washed with 5 L of cold water. ethanol (-8 to -10??C), purged with nitrogen under room vacuum and then dried in a vacuum oven (35??C). This resulted in the isolation of 1.23 Kg (86.3%) of white crystalline solid.

(+)-N,N'-(1S,2S)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE) Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-N,N'-(1S,2S)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE) Suppliers

China 36 Germany 1 Japan 1 Norway 1 Switzerland 1 United Kingdom 1 United States 7 Global 48

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172138-95-3, (+)-N,N'-(1S,2S)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE)Related Search:

N-Acetyl-L-cysteine N-CARBAMYL-L-GLUTAMIC ACID 2,6-Bis[(4S)-phenyl-2-oxazolin-2-yl]pyridine 1,2-Diaminocyclohexane PYRIDINE-2-CARBOXAMIDE (-)-N,N'-(1R,2R)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE) N,N'-BIS-2-PYRIDYLMETHYL ETHYLENEDIAMINE (+/-)-trans-1,2-Diaminocyclohexane (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine (1S,2S)-(+)-1,2-Diaminocyclohexane 2-(CYCLOHEXYLAMINOMETHYL)PYRIDINE (+)-N,N'-(1S,2S)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE)

1S,2S- N,N’-1,2-Diaminocyclohexanediylbis (2-pyridinecarboxamide)

2,6-Bis[(4S)-benzyl-2-oxazolin-2-yl]-pyridine

(+)-N,N'-(1S,2S)-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide),min.98%

(+)-N,N''-(1S,2S)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE), MIN. 98%

N-((1S,2S)-2-(picolinamido)cyclohexyl)picolinamide

(1S,2S)-N,Nμ-1,2-Cyclohexanediylbis(2-pyridinecarboxamide), (+)-N,Nμ-(1S,2S)-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide), (1S,2S)-(+)-1,2-Bis[(2-pyridinylcarbonyl)amino]cyclohexane, (1S,2S)-1,2-Bis(2-pyridinecarboxamido)cyclohexane

(S,S)-DACH-pyridyl Trost ligand

(1R,2R)-(-)-1,2-Bis[(2-pyridinylcarbonyl)amino]cyclohexane

(1R,2R)-N,Nμ-1,2-Cyclohexanediylbis(2-pyridinecarboxamide), (1R,2R)-1,2-Bis(2-pyridinecarboxamido)cyclohexane

(S,S)-DACH-pyridyl Trost ligand 95%

(+)-N,N'-(1S,2S)-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide),98%

(1S,2S)-N,N'-1,2-Diaminocyclohexanediylbis(2- pyridinecarboxamide),99%e.e.

(+)-N,N'-(1S,2S)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE),MIN.98%(S,S)-DACH-PYRIDYLTROSTLIGAND

(+)-N,N'-(1S,2S)-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide), min. 98% (S,S)-DACH-Pyridyl Trost Ligand

N-[(1S,2S)-2-(pyridine-2-carbonylamino)cyclohexyl]pyridine-2-carboxamide

(1S,2S)-1,2-Bis(2-pyridinecarboxamido)cyclohexane

2-Pyridinecarboxamide, N,N'-(1S,2S)-1,2-cyclohexanediylbis-

(+)-N,N'-(1S,2S)-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide)

N,N'-((1S,2S)-Cyclohexane-1,2-diyl)dipicolinamide

(1S,2S)-N,N'-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide)

172138-95-3

C18H20N4O2

Chiral Nitrogen

DACH&Trost Series