Benzoylformic acid Property

Melting point:

62-65 °C(lit.)

Boiling point:

84 °C0.1 mm Hg

Density 

1.38

refractive index 

1.4500 (estimate)

Flash point:

147-151°C/12mm

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

methanol: 0.1 g/mL, clear

pka

2.15±0.54(Predicted)

form 

Adhering Crystals, Crystalline Powder or Chunks

color 

White to light yellow

Water Solubility 

very faint turbidity

BRN 

606718

InChIKey

FAQJJMHZNSSFSM-UHFFFAOYSA-N

CAS DataBase Reference

611-73-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzoylformic acid(611-73-4)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-28-36-28A-24-22-37

WGK Germany 

3

RTECS 

DA1480000

HS Code 

29183000

Toxicity

LD50 ivn-mus: 180 mg/kg CSLNX* NX#04110

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Benzoylformic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow adhering crystals,

Uses

Phenylglyoxylic Acid (cas# 611-73-4) is a compound useful in organic synthesis.

Uses

Phenylglyoxylic acid can be used as a precursor in the synthesis of:

• O-acyl acetanilides by decarboxylative o-acylation of acetanilides using Pd catalyst.
• Phenylhydroxycarbene by high-vacuum flash pyrolysis.
• 2-arylbenzothiazoles by reacting with o-aminothiophenol using ammonium niobium oxalate (ANO) as a catalyst.
• 3-aryl-2H-benzo[b][1,4]benzoxazin-2-ones by treating with o-aminophenol in the presence of ammonium niobium oxalate catalyst.
• 2-aryl benzothiazoles through potassium persulfate (K₂S₂O₈)-mediated oxidative condensation of benzothiazoles.

Definition

ChEBI: A 2-oxo monocarboxylic acid that is glyoxylic acid in which the aldehyde hydrogen is substituted by a phenyl group.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 26, p. 1631, 1983 DOI: 10.1021/jm00365a015
Organic Syntheses, Coll. Vol. 1, p. 241, 1941
Tetrahedron Letters, 17, p. 3735, 1976 DOI: 10.1016/S0040-4039(00)93096-X

Safety Profile

A poison by intravenous route. When heated to decomposition it emits acrid smoke and irritating vapors.

Synthesis

The synthesis of Benzoylformic acid is as follows:Acetophenone (120 g, 1 mol) was dissolved in 2000 ml of pyridine, and 165 g (1.5 mol) of selenium dioxide was added under stirring.The mixture was refluxed for 3 hours and left to cool overnight.Filter through celite, wash the filter cake with xylene, and combine the filtrate and washings with azeotropic evaporation.The evaporated residue was dissolved in 1 L of ethyl acetate and washed with 300 ml of 10% dilute hydrochloric acid.The organic layer was washed with 400 ml of 5% sodium hydroxide solution, and the washed aqueous layer was adjusted to pH 2-3 with 10% dilute hydrochloric acid.A white solid precipitates, is filtered, the filter cake is washed with water, and dried to obtain 120 g of a white solid.Yield: 87%, purity: 99.2%.

Purification Methods

If the sample is oily, then it may contain H2O. In this case dry it in a vacuum desiccator over P2O5 or KOH until crisp. For further purification dissolve 5.5g in hot CCl4 (750mL), add charcoal (2g, this is necessary otherwise the acid may separate as an oil), filter, cool in ice-water until crystallisation is complete. Filter the acid off, and the solvent on the crystals is removed by keeping the acid (4.5g) in a vacuum desiccator for 2 days. Slightly yellow crystals are obtained. It can be recrystallised also from *C6H6/pet ether, and can be distilled in a vacuum. The acid is estimated by titration with standard NaOH. The phenylhydrazone is recrystallised from EtOH, m 163-164o, and the semicarbazone acid has m 259o(dec) (from EtOH). The methyl ester distils at 137o/14mm, 110-111o/2mm, n 20 1.5850. [Baert & Kates J Am Chem Soc 67 1482 1945, Schaffer & Corey J Org Chem 24 1825 1959, Beilstein 10 H 654, 10 IV 2737.]