21-hydroxyoligomycin A

Product Name: 21-hydroxyoligomycin A
CAS No.: 102042-09-1
Chemical Name: 21-hydroxyoligomycin A
Synonyms: 21-hydroxyoligomycin A;HydroxyoligoMycin A, 21-;NeMadectin oMega, LL-F28249 oMega;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15,23-pentahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'S,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-
CBNumber: CB11332057
Molecular Formula: C45H74O12
Formula Weight: 807.06
MOL File: 102042-09-1.mol

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21-hydroxyoligomycin A Property

Boiling point:: 916.6±65.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: White to off-white powder.
pka: 12.52±0.70(Predicted)

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Safety

HS Code: 29419000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20599
Product name: 21-hydroxy Oligomycin A
Purity: ≥95%
Packaging: 1mg
Price: $332
Updated: 2024/03/01

Cayman Chemical

Product number: 20599
Product name: 21-hydroxy Oligomycin A
Purity: ≥95%
Packaging: 5mg
Price: $663
Updated: 2024/03/01

TRC

Product number: H942793
Product name: 21-HydroxyoligomycinA
Packaging: 1mg
Price: $315
Updated: 2021/12/16

ApexBio Technology

Product number: C4205
Product name: 21-hydroxyOligomycinA
Packaging: 5mg
Price: $1498
Updated: 2021/12/16

ApexBio Technology

Product number: C4205
Product name: 21-hydroxyOligomycinA
Packaging: 1mg
Price: $428
Updated: 2021/12/16

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21-hydroxyoligomycin A Chemical Properties,Usage,Production

Uses

21-Hydroxyoligomycin A is a rare member of the oligomycin class isolated as a co-metabolite of nemadectin, hence its original naming as nemadectin omega. Only limited literature references to this metabolite are available. However, in-house testing suggests that 21-hydroxyoligomycin has a more selective action against mammalian tumour cell lines than oligomycin A, exhibiting only weak antifungal and nematocidal activity.

Uses

21-Hydroxyoligomycin A is an oligomycin antibiotic coisolated with nemadectins.

Biological Activity

21-hydroxy oligomycin a is an antibiotic which was first isolated from s. cyaneogriseus ssp.noncyanogenus [1]. 21-hydroxy oligomycin a functions as μm inhibitor of the multidrug efflux pump p-gp, and low nm inhibitors of k-ras pm localization [1].cancer cell viability screening confirmed that 21-hydroxy oligomycin a was cytotoxic to human colorectal carcinoma cells (ic50 > 3 μm), and was inhibitor of the abc transporter efflux pump p-glyco-protein (p-gp). significantly, 21-hydroxy oligomycin a was exceptionally potent inhibitor of k-ras pm localisation with emax of 0.67–0.75 and an ic50 of 1.5–14 nm [1]. 21-hydroxy oligomycin a was inhibitor of k-ras pm localisation in mdck cell with an ic50 of 4.82 ± 0.70 nm. 21-hydroxy oligomycin a was moderately cytotoxic towards both sw620 and sw620 ad300 cells with the ic50 of 14.4 ± 0.6 and 11.8 ± 3.1 μm, respectively. in the flow cytometry assay, 21-hydroxy oligomycin a (20 μm) increased intracellular calcein fluorescence significantly when compared with the negative control [1].

References

[1] salim a a, tan l, huang x c, et al. oligomycins as inhibitors of k-ras plasma membrane localisation[j]. organic & biomolecular chemistry, 2016, 14(2): 711-715.

21-hydroxyoligomycin A Preparation Products And Raw materials

Raw materials

Preparation Products

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21-hydroxyoligomycin A Suppliers

China 9 France 1 Germany 1 India 1 United Kingdom 2 United States 5 Global 19

Shanghai EFE Biological Technology Co., Ltd.

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102042-09-1, 21-hydroxyoligomycin ARelated Search:

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21-hydroxyoligomycin A

HydroxyoligoMycin A, 21-

NeMadectin oMega, LL-F28249 oMega

Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15,23-pentahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'S,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-

102042-09-1

C45H74O12

Antibiotic