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FOSTRIECIN SODIUM SALT

Product Name
FOSTRIECIN SODIUM SALT
CAS No.
87860-39-7
Chemical Name
FOSTRIECIN SODIUM SALT
Synonyms
FST;CL-920;FST344;FOSTRIECIN;PHOSPHOTRIENIN;ci920sodiumsalt;cl1565asodiumsalt;FOSTRIECIN SODIUM;FOSTRIECIN SODIUM SALT;antibioticci920sodiumsalt
CBNumber
CB8295127
Molecular Formula
C19H28NaO9P
Formula Weight
454.39
MOL File
87860-39-7.mol
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FOSTRIECIN SODIUM SALT Property

storage temp. 
-20°C
solubility 
Soluble in H2O
form 
Colorless solid
Water Solubility 
Soluble to 100 mM in water
InChIKey
GMNLFZGMQHSFFV-DSXPUHJBNA-N
SMILES
[C@@H](OP(O)(O)=O)(C[C@@H](O)/C=C\C=C/C=C/CO)[C@@](O)(C)/C=C/[C@H]1CC=CC(=O)O1.[NaH] |&1:0,7,17,22,r|
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Safety

WGK Germany 
3
RTECS 
UQ0600000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F4425
Product name
Fostriecin sodium salt from Streptomyces pulveraceus
Purity
≥98% (HPLC)
Packaging
10μg
Price
$601
Updated
2024/03/01
Cayman Chemical
Product number
14749
Product name
Fostriecin (sodium salt)
Purity
≥95%
Packaging
100μg
Price
$364
Updated
2024/03/01
Cayman Chemical
Product number
14749
Product name
Fostriecin (sodium salt)
Purity
≥95%
Packaging
500μg
Price
$999
Updated
2024/03/01
Tocris
Product number
1840
Product name
Fostriecin, Sodium Salt,
Purity
≥98%(HPLC)
Packaging
50U
Price
$292
Updated
2021/12/16
TRC
Product number
F745803
Product name
Fostriecin
Packaging
100μg
Price
$310
Updated
2021/12/16
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FOSTRIECIN SODIUM SALT Chemical Properties,Usage,Production

Description

Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antibiotic.

Uses

Antineoplastic. Fostriecin is a Topo II, PP1, and PP2A inhibitor.

Uses

Fostriecin has been used as a protein phosphatases type 2A (PP2A) inhibitor to study its effects on phosphorylated myosin light chain (pMLC) levels in axon initial segments (AIS). It has also been used as a PP2A inhibitor to study its effects on the regulation of protein kinase Akt (pAKT) by dopamine (DA) in larval zebrafish brain.

Biological Activity

Originally identified as an antitumor antibiotic from Streptomyces pulveraceous . Displays potent inhibition of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC 50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC 50 = 40 μ M) and protein phosphatase type 1 (PP1) (IC 50 = 131 μ M) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo .

Biochem/physiol Actions

Fostriecin is a natural inhibitor of serine/ threonine phosphatases. It is a phosphate monoester produced by fermentation beer of Streptomyces pulveraceus. Fostriecin is a strong inhibitor of protein phosphatases type 2A and 4 (PP2A and PP4) and a weak inhibitor of protein phosphatases type 1 and 5 (PP1 and PP5). It exhibits anti-tumor activity against several tumor cells in vitro and L1210 and P388 leukemias in vivo. The anti-tumor activity of fostriecin is due to its ability to interfere with the reversible?phosphorylation?of proteins that are involved in the progression of the cell cycle. It also exhibits cytotoxic effects. Fostriecin can inhibit the DNA, RNA and protein synthesis.

in vitro

a human tumor cloning assay was adopted to investigate the antineoplastic activity of fostriecin. variety of histologic tumor cells exposure to 10 mg/ml fostriecin resulted in 27% in vitro anticancer response. in another study using hela cells, by suppressing the topo ii catalytic activity, 0.22 mm fostriecin could lead to more than 90% inhibition of cancer cell dna synthesis. [2,3]

in vivo

fostriecin showed intensively cytotoxicity against a number of cancer cell lines and had a strong antitumor effect in animals. 10 mg/ml fostriecin could substantially suppress p388 and l1210 leukemias in mice. [2,3]

IC 50

inhibit protein phosphatase types 2a (pp2a) and 4 (pp4) intensively with an ic50 of 1.5 nm and 3 nm respectively. inhibit topoisomerase ii (topo ii) and protein phosphatase type 1 (pp1) slightly with an ic50 of 40 μm and 131 μm respectively.

storage

-20°C (desiccate)

References

[1] zhang x, wu j, fang l, willis wd. the effects of protein phosphatase inhibitors on the duration of central sensitization of rat dorsal horn neurons following injection of capsaicin. mol pain. 2006 jul; 2(23). doi:10.1186/1744-8069-2-23.
[2] scheithauer w, von hoff dd, clark g, shillis jl, elslager ef. in vitro activity of the novel antitumor antibiotic fostriecin (ci-920) in a human tumor cloning assay. eur j cancer res & clin oncol. 1986 aug; 22(8): 921-6.
[3] gedik cm, collins ar. comparison of effects of fostriecin, novobiocin, and camptothecin, inhibitors of dna topoisomerases, on dna replication and repair in human cells. nnucleic acids res. 1990 aug; 18(4):1008-13.
[4] le lh, erlichman c, pillon l, thiessen jj, day a, wainman n, eisenhauer ea, moore mj. phase i and pharmacokinetic study of fostriecin given as an intravenous bolus daily for five consecutive days.invest new drugs. 2004 apr; 22(2):159-67.

FOSTRIECIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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FOSTRIECIN SODIUM SALT Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Creative Peptides
Tel
Email
info@creative-peptides.com
Country
United States
ProdList
6083
Advantage
56
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
9996
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3061
Advantage
58
Hong Kong Tiansheng New Material Trading Co., Ltd
Tel
+8617320695765
Fax
17320695765
Email
zxx@hktiansheng.com
Country
China
ProdList
973
Advantage
58
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View Lastest Price from FOSTRIECIN SODIUM SALT manufacturers

Shanghai Longyu Biotechnology Co., Ltd.
Product
fst344 87860-39-7
Price
US $1.00/box
Min. Order
1box
Purity
99.99
Supply Ability
2000000BOXES
Release date
2024-11-23
Shaanxi Dideu Medichem Co. Ltd
Product
FOSTRIECIN SODIUM SALT 87860-39-7
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-07
.GZ HONESTCHEM CO.,LTD
Product
fst
Price
US $1.00/g/ml
Min. Order
1kit
Purity
99.9%
Supply Ability
100KG
Release date
2019-10-20

87860-39-7, FOSTRIECIN SODIUM SALTRelated Search:


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  • (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-onesodiumsalt
  • Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem
  • (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one monosodium salt
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