FOSTRIECIN SODIUM SALT

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FOSTRIECIN SODIUM SALT

Product Name: FOSTRIECIN SODIUM SALT
CAS No.: 87860-39-7
Chemical Name: FOSTRIECIN SODIUM SALT
Synonyms: FST;CL-920;FST344;FOSTRIECIN;PHOSPHOTRIENIN;ci920sodiumsalt;cl1565asodiumsalt;FOSTRIECIN SODIUM;FOSTRIECIN SODIUM SALT;antibioticci920sodiumsalt
CBNumber: CB8295127
Molecular Formula: C19H28NaO9P
Formula Weight: 454.39
MOL File: 87860-39-7.mol

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FOSTRIECIN SODIUM SALT Property

storage temp.: -20°C
solubility: Soluble in H2O
form: Colorless solid
Water Solubility: Soluble to 100 mM in water
InChIKey: GMNLFZGMQHSFFV-DSXPUHJBNA-N
SMILES: [C@@H](OP(O)(O)=O)(C[C@@H](O)/C=C\C=C/C=C/CO)[C@@](O)(C)/C=C/[C@H]1CC=CC(=O)O1.[NaH] |&1:0,7,17,22,r|

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Safety

WGK Germany: 3
RTECS: UQ0600000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F4425
Product name: Fostriecin sodium salt from Streptomyces pulveraceus
Purity: ≥98% (HPLC)
Packaging: 10μg
Price: $601
Updated: 2024/03/01

Cayman Chemical

Product number: 14749
Product name: Fostriecin (sodium salt)
Purity: ≥95%
Packaging: 100μg
Price: $364
Updated: 2024/03/01

Cayman Chemical

Product number: 14749
Product name: Fostriecin (sodium salt)
Purity: ≥95%
Packaging: 500μg
Price: $999
Updated: 2024/03/01

Tocris

Product number: 1840
Product name: Fostriecin, Sodium Salt,
Purity: ≥98%(HPLC)
Packaging: 50U
Price: $292
Updated: 2021/12/16

TRC

Product number: F745803
Product name: Fostriecin
Packaging: 100μg
Price: $310
Updated: 2021/12/16

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FOSTRIECIN SODIUM SALT Chemical Properties,Usage,Production

Description

Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC₅₀s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC₅₀s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antibiotic.

Uses

Antineoplastic. Fostriecin is a Topo II, PP1, and PP2A inhibitor.

Uses

Fostriecin has been used as a protein phosphatases type 2A (PP2A) inhibitor to study its effects on phosphorylated myosin light chain (pMLC) levels in axon initial segments (AIS). It has also been used as a PP2A inhibitor to study its effects on the regulation of protein kinase Akt (pAKT) by dopamine (DA) in larval zebrafish brain.

Biological Activity

Originally identified as an antitumor antibiotic from Streptomyces pulveraceous . Displays potent inhibition of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC 50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC 50 = 40 μ M) and protein phosphatase type 1 (PP1) (IC 50 = 131 μ M) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo .

Biochem/physiol Actions

Fostriecin is a natural inhibitor of serine/ threonine phosphatases. It is a phosphate monoester produced by fermentation beer of Streptomyces pulveraceus. Fostriecin is a strong inhibitor of protein phosphatases type 2A and 4 (PP2A and PP4) and a weak inhibitor of protein phosphatases type 1 and 5 (PP1 and PP5). It exhibits anti-tumor activity against several tumor cells in vitro and L1210 and P388 leukemias in vivo. The anti-tumor activity of fostriecin is due to its ability to interfere with the reversible?phosphorylation?of proteins that are involved in the progression of the cell cycle. It also exhibits cytotoxic effects. Fostriecin can inhibit the DNA, RNA and protein synthesis.

in vitro

a human tumor cloning assay was adopted to investigate the antineoplastic activity of fostriecin. variety of histologic tumor cells exposure to 10 mg/ml fostriecin resulted in 27% in vitro anticancer response. in another study using hela cells, by suppressing the topo ii catalytic activity, 0.22 mm fostriecin could lead to more than 90% inhibition of cancer cell dna synthesis. [2,3]

in vivo

fostriecin showed intensively cytotoxicity against a number of cancer cell lines and had a strong antitumor effect in animals. 10 mg/ml fostriecin could substantially suppress p388 and l1210 leukemias in mice. [2,3]

IC 50

inhibit protein phosphatase types 2a (pp2a) and 4 (pp4) intensively with an ic50 of 1.5 nm and 3 nm respectively. inhibit topoisomerase ii (topo ii) and protein phosphatase type 1 (pp1) slightly with an ic50 of 40 μm and 131 μm respectively.

storage

-20°C (desiccate)

References

[1] zhang x, wu j, fang l, willis wd. the effects of protein phosphatase inhibitors on the duration of central sensitization of rat dorsal horn neurons following injection of capsaicin. mol pain. 2006 jul; 2(23). doi:10.1186/1744-8069-2-23.
[2] scheithauer w, von hoff dd, clark g, shillis jl, elslager ef. in vitro activity of the novel antitumor antibiotic fostriecin (ci-920) in a human tumor cloning assay. eur j cancer res & clin oncol. 1986 aug; 22(8): 921-6.
[3] gedik cm, collins ar. comparison of effects of fostriecin, novobiocin, and camptothecin, inhibitors of dna topoisomerases, on dna replication and repair in human cells. nnucleic acids res. 1990 aug; 18(4):1008-13.
[4] le lh, erlichman c, pillon l, thiessen jj, day a, wainman n, eisenhauer ea, moore mj. phase i and pharmacokinetic study of fostriecin given as an intravenous bolus daily for five consecutive days.invest new drugs. 2004 apr; 22(2):159-67.

FOSTRIECIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from FOSTRIECIN SODIUM SALT manufacturers

Shanghai Longyu Biotechnology Co., Ltd.

Product: fst344 87860-39-7
Price: US $1.00/box
Min. Order: 1box
Purity: 99.99
Supply Ability: 2000000BOXES
Release date: 2024-11-23

Shaanxi Dideu Medichem Co. Ltd

Product: FOSTRIECIN SODIUM SALT 87860-39-7
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-07

.GZ HONESTCHEM CO.,LTD

Product: fst
Price: US $1.00/g/ml
Min. Order: 1kit
Purity: 99.9%
Supply Ability: 100KG
Release date: 2019-10-20

87860-39-7, FOSTRIECIN SODIUM SALTRelated Search:

MEPARTRICIN 21-hydroxyoligomycin A anguinomycin A Hexacyclinic acid KAZUSAMYCIN A FROM STREPTOMYCES SP. echinosporin Daunorubicin hydrochloride herbimycin C KIGAMICIN C PD 124895 Cladospirone bisepoxide Cochliodinol,fromChaetomiumglobosum. 6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosy l)-1-hydroxy-10,12-dimethoxy-8-methyl- FOSTRIECIN SODIUM SALT Fostriecin Fostriecin, Streptomyces pulveraceous Fostriecin,StreptomycesPulveraceoussubsp.Fostreus FOSTRIECIN

11-tridecatetraenyl)-monosodiumsalt

antibioticci920sodiumsalt

antibioticcl1565asodiumsalt

ci920sodiumsalt

cl1565asodiumsalt

PHOSPHOTRIENIN

fostriecin sodium salt from streptomyces pulveraceus

FST

FOSTRIECIN

FOSTRIECIN SODIUM

FOSTRIECIN SODIUM SALT

FOSTRIECIN, SODIUM SALT, STREPTOMYCES PULVERACEOUS

CL-920

(6R)-5,6-DIHYDRO-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-TRIHYDROXY-3-METHYL-4-(PHOSPHONOOXY)-1,7,9,11-TRIDECATETRAENYL]-2H-PYRAN-2-ONE SODIUM SALT

(6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-onesodiumsalt

Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem

(6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one monosodium salt

FST344

Fostriecin sodium salt from Streptomyces pulveraceus >=98% (HPLC)

Human FST Protein, Fc Tag

FOSTRIECIN SODIUM SALT USP/EP/BP

87860-39-7

C19H27O9P

C19H26O9PNa

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Kinase/Phosphatase Biology

Protein Phosphatase 2 (PP2)

Serine/Threonine Phosphatase Inhibitors

Active Pharmaceutical Ingredients

FST