FOSTRIECIN SODIUM SALT

ChemicalBook > CAS DataBase List > FOSTRIECIN SODIUM SALT

FOSTRIECIN SODIUM SALT

Product Name: FOSTRIECIN SODIUM SALT
CAS No.: 87860-39-7
Chemical Name: FOSTRIECIN SODIUM SALT
Synonyms: FST;CL-920;FST344;FOSTRIECIN;PHOSPHOTRIENIN;ci920sodiumsalt;cl1565asodiumsalt;FOSTRIECIN SODIUM;FOSTRIECIN SODIUM SALT;antibioticci920sodiumsalt
CBNumber: CB8295127
Molecular Formula: C19H28NaO9P
Formula Weight: 454.39
MOL File: 87860-39-7.mol

Less

FOSTRIECIN SODIUM SALT Property

storage temp.: -20°C
solubility: Soluble in H2O
form: Colorless solid
Water Solubility: Soluble to 100 mM in water
InChIKey: GMNLFZGMQHSFFV-DSXPUHJBNA-N
SMILES: [C@@H](OP(O)(O)=O)(C[C@@H](O)/C=C\C=C/C=C/CO)[C@@](O)(C)/C=C/[C@H]1CC=CC(=O)O1.[NaH] |&1:0,7,17,22,r|

Less

Safety

WGK Germany: 3
RTECS: UQ0600000

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F4425
Product name: Fostriecin sodium salt from Streptomyces pulveraceus
Purity: ≥98% (HPLC)
Packaging: 10μg
Price: $601
Updated: 2024/03/01

Cayman Chemical

Product number: 14749
Product name: Fostriecin (sodium salt)
Purity: ≥95%
Packaging: 100μg
Price: $364
Updated: 2024/03/01

Cayman Chemical

Product number: 14749
Product name: Fostriecin (sodium salt)
Purity: ≥95%
Packaging: 500μg
Price: $999
Updated: 2024/03/01

Tocris

Product number: 1840
Product name: Fostriecin, Sodium Salt,
Purity: ≥98%(HPLC)
Packaging: 50U
Price: $292
Updated: 2021/12/16

TRC

Product number: F745803
Product name: Fostriecin
Packaging: 100μg
Price: $310
Updated: 2021/12/16

Less

FOSTRIECIN SODIUM SALT Chemical Properties,Usage,Production

Description

Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC₅₀s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC₅₀s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antibiotic.

Uses

Antineoplastic. Fostriecin is a Topo II, PP1, and PP2A inhibitor.

Uses

Fostriecin has been used as a protein phosphatases type 2A (PP2A) inhibitor to study its effects on phosphorylated myosin light chain (pMLC) levels in axon initial segments (AIS). It has also been used as a PP2A inhibitor to study its effects on the regulation of protein kinase Akt (pAKT) by dopamine (DA) in larval zebrafish brain.

Biological Activity

Originally identified as an antitumor antibiotic from Streptomyces pulveraceous . Displays potent inhibition of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC 50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC 50 = 40 μ M) and protein phosphatase type 1 (PP1) (IC 50 = 131 μ M) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo .

Biochem/physiol Actions

Fostriecin is a natural inhibitor of serine/ threonine phosphatases. It is a phosphate monoester produced by fermentation beer of Streptomyces pulveraceus. Fostriecin is a strong inhibitor of protein phosphatases type 2A and 4 (PP2A and PP4) and a weak inhibitor of protein phosphatases type 1 and 5 (PP1 and PP5). It exhibits anti-tumor activity against several tumor cells in vitro and L1210 and P388 leukemias in vivo. The anti-tumor activity of fostriecin is due to its ability to interfere with the reversible?phosphorylation?of proteins that are involved in the progression of the cell cycle. It also exhibits cytotoxic effects. Fostriecin can inhibit the DNA, RNA and protein synthesis.

in vitro

a human tumor cloning assay was adopted to investigate the antineoplastic activity of fostriecin. variety of histologic tumor cells exposure to 10 mg/ml fostriecin resulted in 27% in vitro anticancer response. in another study using hela cells, by suppressing the topo ii catalytic activity, 0.22 mm fostriecin could lead to more than 90% inhibition of cancer cell dna synthesis. [2,3]

in vivo

fostriecin showed intensively cytotoxicity against a number of cancer cell lines and had a strong antitumor effect in animals. 10 mg/ml fostriecin could substantially suppress p388 and l1210 leukemias in mice. [2,3]

IC 50

inhibit protein phosphatase types 2a (pp2a) and 4 (pp4) intensively with an ic50 of 1.5 nm and 3 nm respectively. inhibit topoisomerase ii (topo ii) and protein phosphatase type 1 (pp1) slightly with an ic50 of 40 μm and 131 μm respectively.

storage

-20°C (desiccate)

References

[1] zhang x, wu j, fang l, willis wd. the effects of protein phosphatase inhibitors on the duration of central sensitization of rat dorsal horn neurons following injection of capsaicin. mol pain. 2006 jul; 2(23). doi:10.1186/1744-8069-2-23.
[2] scheithauer w, von hoff dd, clark g, shillis jl, elslager ef. in vitro activity of the novel antitumor antibiotic fostriecin (ci-920) in a human tumor cloning assay. eur j cancer res & clin oncol. 1986 aug; 22(8): 921-6.
[3] gedik cm, collins ar. comparison of effects of fostriecin, novobiocin, and camptothecin, inhibitors of dna topoisomerases, on dna replication and repair in human cells. nnucleic acids res. 1990 aug; 18(4):1008-13.
[4] le lh, erlichman c, pillon l, thiessen jj, day a, wainman n, eisenhauer ea, moore mj. phase i and pharmacokinetic study of fostriecin given as an intravenous bolus daily for five consecutive days.invest new drugs. 2004 apr; 22(2):159-67.

FOSTRIECIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

Less

FOSTRIECIN SODIUM SALT Suppliers

China 47 Germany 1 Switzerland 2 United Kingdom 7 United States 9 Global 66

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com
Country: China
ProdList: 2867
Advantage: 52

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 9859
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3063
Advantage: 58

Hong Kong Tiansheng New Material Trading Co., Ltd

Tel: +8617320695765
Fax: 17320695765
Email: zxx@hktiansheng.com
Country: China
ProdList: 981
Advantage: 58

Qiuxian Baitai New Material Co., LTD

Tel: +8618330912755
Fax: +8619932103556
Email: sale2@hbyalin.com
Country: China
ProdList: 1677
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 28863
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 9177
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 15093356674;
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30255
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569265 +86-18612256290
Fax: 029-88380327
Email: 1056@dideu.com
Country: China
ProdList: 3430
Advantage: 58

Shanghai meikai technology co., ltd

Tel: 021-18721550-091 18721550091
Fax: 微信18721550091
Email: yangdong@pharma.com
Country: China
ProdList: 4123
Advantage: 58

Wuhan Chemstan Biotechnology Co., Ltd.

Tel: 15926423062
Fax: QQ：422450190
Email: 422450190@qq.com
Country: China
ProdList: 10132
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8141
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 4030
Advantage: 58

Shanghai Getian Industrial Co., LTD

Tel: +86-15373193816 +86-15373193816
Email: mike@ge-tian.com
Country: China
ProdList: 272
Advantage: 58

zhuzhou dingcheng meihei comestic co.,ltd

Tel: +undefined18873369619
Email: dingchengbusiness8@163.com
Country: China
ProdList: 242
Advantage: 58

Anhui Ruihan Technology Co., Ltd

Tel: +8617756083858
Email: daisy@anhuiruihan.com
Country: China
ProdList: 994
Advantage: 58

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8474
Advantage: 58

Wuhan Han Sheng New Material Technology Co.，Ltd

Tel: +8617798174412
Email: admin01@hsnm.com.cn
Country: China
ProdList: 2118
Advantage: 58

Jiangsu shring Biopharma Co., Ltd.

Tel: +8613372282299
Email: sales@shringchem.com
Country: China
ProdList: 3545
Advantage: 58

Hebei Shengyuan Jinlong Import and Export Co. LTD

Tel: +8617367750398
Email: info@hebeisyjl.com
Country: China
ProdList: 1867
Advantage: 58

Hubei Lange Biotechnology Co., Ltd.

Tel: +8617762501948
Email: sales2@langebiotech.com
Country: China
ProdList: 154
Advantage: 58

Zhuzhou Yaozhijie Chemical Co., LTD

Tel: +8618073316972
Email: sales@goodpeptides.com
Country: China
ProdList: 244
Advantage: 58

.GZ HONESTCHEM CO.,LTD

Tel: +86-15013270415
Fax: +8613437848121
Email: honestchemical@foxmail.com
Country: China
ProdList: 247
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Shanghai Jingke Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: jingkehuaxue@163.com
Country: CHINA
ProdList: 6974
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6921
Advantage: 58

Shenzhen Xinbosheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: service@neobioscience.com
Country: CHINA
ProdList: 6164
Advantage: 58

Wuhan Aibotek Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: tech@abclonal.com
Country: CHINA
ProdList: 6796
Advantage: 58

Nanjing Shanben Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: sales@sciben.com
Country: CHINA
ProdList: 6053
Advantage: 58

Beijing Bai Ao Si Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: yangmei@bioneeds.net
Country: CHINA
ProdList: 6999
Advantage: 58

Guangzhou Ruiboao Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@raybiotech.com
Country: CHINA
ProdList: 2408
Advantage: 58

Shanghai Qumai Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 13770640776@189.cn
Country: CHINA
ProdList: 6227
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6942
Advantage: 58

Beijing Bi Orange Blue Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: bo49855987@163.com
Country: CHINA
ProdList: 6827
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6979
Advantage: 58

Nanjing Sai Ruirui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: sales@shrbio.com
Country: CHINA
ProdList: 6873
Advantage: 58

Guangzhou WeiBo Chemical Co., Ltd.

Tel: --
Fax: --
Email: weibochem@163.com
Country: China
ProdList: 6187
Advantage: 67

Less

View Lastest Price from FOSTRIECIN SODIUM SALT manufacturers

zhuzhou dingcheng meihei comestic co.,ltd

Product: FST 344 87860-39-7
Price: US $30.00/Box
Min. Order: 1Box
Purity: 99.99%
Supply Ability: 10000000000
Release date: 2023-12-07

Shanghai Getian Industrial Co., LTD

Product: FOSTRIECIN SODIUM SALT 87860-39-7
Price: US $25.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 10000box
Release date: 2024-04-25

Shaanxi Dideu Medichem Co. Ltd

Product: FOSTRIECIN SODIUM SALT 87860-39-7
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-07

87860-39-7, FOSTRIECIN SODIUM SALTRelated Search:

MEPARTRICIN 21-hydroxyoligomycin A anguinomycin A Hexacyclinic acid KAZUSAMYCIN A FROM STREPTOMYCES SP. echinosporin Daunorubicin hydrochloride herbimycin C KIGAMICIN C PD 124895 Cladospirone bisepoxide Cochliodinol,fromChaetomiumglobosum. 6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosy l)-1-hydroxy-10,12-dimethoxy-8-methyl- FOSTRIECIN SODIUM SALT Fostriecin Fostriecin, Streptomyces pulveraceous Fostriecin,StreptomycesPulveraceoussubsp.Fostreus FOSTRIECIN

11-tridecatetraenyl)-monosodiumsalt

antibioticci920sodiumsalt

antibioticcl1565asodiumsalt

ci920sodiumsalt

cl1565asodiumsalt

PHOSPHOTRIENIN

fostriecin sodium salt from streptomyces pulveraceus

FST

FOSTRIECIN

FOSTRIECIN SODIUM

FOSTRIECIN SODIUM SALT

FOSTRIECIN, SODIUM SALT, STREPTOMYCES PULVERACEOUS

CL-920

(6R)-5,6-DIHYDRO-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-TRIHYDROXY-3-METHYL-4-(PHOSPHONOOXY)-1,7,9,11-TRIDECATETRAENYL]-2H-PYRAN-2-ONE SODIUM SALT

(6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-onesodiumsalt

Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem

(6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one monosodium salt

FST344

Fostriecin sodium salt from Streptomyces pulveraceus >=98% (HPLC)

Human FST Protein, Fc Tag

FOSTRIECIN SODIUM SALT USP/EP/BP

87860-39-7

C19H27O9P

C19H26O9PNa

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Kinase/Phosphatase Biology

Protein Phosphatase 2 (PP2)

Serine/Threonine Phosphatase Inhibitors

Active Pharmaceutical Ingredients

FST