L(+)-Lactic acid Property

Melting point:

52-54°C

alpha 

-13.5 º (c=2.5, 1.5N NaOH)

Boiling point:

125 °C

Density 

1.206 g/mL at 25 °C

vapor pressure 

0.038Pa at 25℃

FEMA 

2611 | LACTIC ACID

refractive index 

n20/D 1.427

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

H₂O: 10 mg/mL, clear, colorless

form 

Powder/Solid

pka

pK at 25°, 3.79

color 

White

Odor

odorless acidic

Odor Type

odorless

optical activity

[α]20/D 13.5°, c = 2.5 in 1.5 M NaOH

Water Solubility 

SOLUBLE

Sensitive 

Hygroscopic

Merck 

14,5337

JECFA Number

930

BRN 

1720251

InChIKey

JVTAAEKCZFNVCJ-REOHCLBHSA-N

LogP

-0.54 at 20℃

CAS DataBase Reference

79-33-4(CAS DataBase Reference)

NIST Chemistry Reference

(s)-2-Hydroxypropanoic acid(79-33-4)

EPA Substance Registry System

L-Lactic acid (79-33-4)

Safety

Hazard Codes 

Xi,C

Risk Statements 

38-41-34-36/37/38-36-35

Safety Statements 

26-39-45-36/37/39-36

RIDADR 

3261

WGK Germany 

1

RTECS 

OD2800000

F 

3-10

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29181100

Toxicity

LD50 intraperitoneal in mouse: 3194mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

L(+)-Lactic acid Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

Occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-(+)-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and o

Uses

It is most commonly used for fluid resuscitation after blood loss due to trauma, surgery, or burn injury. It is used in the agricultural, chemical, leather processing, pharmaceuticals, and cosmetics industries, used as an electroplating agent, food/feed additive, pH regulator, cleaning/washing agent, and tanning agent; used to flavor animal feeds; used as a solvent and intermediate in chemical production, as a pH regulator in fabric finishing, and in paints, coatings, soaps, and cleaning products; used to make large scale and fine chemicals, pulp-paper-paper products, food products, and plastic products, in mining, health services, agriculture-forestry-fishing, and building and construction work.

Uses

Lactic acid has been used:

• as a component in substrate solution II for lactate dehydrogenase reaction
• as an additive in storage solution A
• as a supplement in the artificial gastric juice preparation for evaluation of degree of resistance Lactobacillus to the gastric stresses

Definition

ChEBI: An optically active form of lactic acid having (S)-configuration.

General Description

L-(+)-Lactic acid is the only naturally occurring lactic acid in humans and mammals. Commercially, few bacteria like Lactobacillus casei, L. delbrueckii, Streptococcus lactis produces L-Lactic acid by fermentation process. Lactic acid activates hydroxycarboxylic acid receptor, G-protein coupled receptor 81 (GPR81).

Flammability and Explosibility

Not classified

Biochem/physiol Actions

L-(+)-Lactic acid is used as a substrate for lactic acid dehydrogenase and lactate oxidase.

Purification Methods

Purify lactic acid by fractional distillation at 0.1mm pressure, followed by fractional crystallisation from diethyl ether/isopropyl ether (1:1, dried with sodium). [Borsook et al. J Biol Chem 102 449 1933.] The solvent mixture, *benzene/diethyl ether (1:1) containing 5% pet ether (b 60-80o) has also been used. [Brin Biochemical Preparations 3 61 1953, Beilstein 3 IV 633.]