Description Preparation Application Biochemical Action Safety
ChemicalBook > CAS DataBase List > 2-Chloropropionic acid

2-Chloropropionic acid

Description Preparation Application Biochemical Action Safety
Product Name
2-Chloropropionic acid
CAS No.
598-78-7
Chemical Name
2-Chloropropionic acid
Synonyms
2-Chloropropionoic acid;2-chloroproprionic acid;NSC-173;NSC-401806;2-chloropropionic;2-Chlorpropionsure;RARECHEM AL BO 1240;2-Chloropropionic ac;-Chloropropanoicacid;2-chloro-propanoicaci
CBNumber
CB6853934
Molecular Formula
C3H5ClO2
Formula Weight
108.52
MOL File
598-78-7.mol
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2-Chloropropionic acid Property

Melting point:
-12--14 °C
Boiling point:
170-190 °C(lit.)
Density 
1.182 g/mL at 25 °C(lit.)
vapor pressure 
4 mm Hg ( 20 °C)
refractive index 
n20/D 1.4345(lit.)
Flash point:
215 °F
storage temp. 
Store below +30°C.
solubility 
H2O: soluble
pka
2.96±0.10(Predicted)
form 
clear liquid
color 
Colorless to Almost colorless
PH
<1 (200g/l, H2O, 20℃)
Water Solubility 
freely soluble
BRN 
1720259
Exposure limits
ACGIH: TWA 0.1 ppm (Skin)
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases.
LogP
0.82 at 20.5℃
CAS DataBase Reference
598-78-7(CAS DataBase Reference)
NIST Chemistry Reference
Propanoic acid, 2-chloro-(598-78-7)
EPA Substance Registry System
2-Chloropropionic acid (598-78-7)
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Safety

Hazard Codes 
C
Risk Statements 
22-35-21/22
Safety Statements 
23-26-28-36-45-36/37/39-28A
RIDADR 
UN 2511 8/PG 3
WGK Germany 
1
RTECS 
UE8575000
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29159080
Hazardous Substances Data
598-78-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
109274
Product name
2-Chloropropionic acid
Purity
92%
Packaging
100g
Price
$39.4
Updated
2024/03/01
Sigma-Aldrich
Product number
109274
Product name
2-Chloropropionic acid
Purity
92%
Packaging
500g
Price
$88.4
Updated
2024/03/01
TCI Chemical
Product number
C0275
Product name
2-Chloropropionic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
C0275
Product name
2-Chloropropionic Acid
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$126
Updated
2024/03/01
Alfa Aesar
Product number
A12860
Product name
(±)-2-Chloropropionic acid, 94%
Packaging
100g
Price
$22.65
Updated
2024/03/01
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2-Chloropropionic acid Chemical Properties,Usage,Production

Description

2-Chloropropionic acid is a colorless to white crystalline solid or liquid that is denser than water; therefore, can sink and mix with water. It has a slight odor and is the simplest chiral chlorocarboxylic aid.

Preparation

2-Chloropropionic acid is prepared from diazotization of L-alanine in hydrochloric acid.

Application

2-Chloropropionic acid is employed in the production of propargyl 2-chloropropionate (PCP), which is an atom transfer radical polymerization (ATRP) initiator, by the esterification of propargyl alcohol.

The chemical is also used in the synthesis of benzimidazole derivatives when treated with o-phenylenediamine phosphate.

It can also be used in the preparation of biologically active chitin derivative (1-carboxyethyl) chitosan.

It is used as a building block for the preparation of herbicides, dyestuffs, pesticides, as well as forestand agro-chemicals.

Biochemical Action

2-Chloropropionic acid induces necrosis of granule cell layer of rat cerebellum when administered orally.

Safety

2-Chloropropionic acid is a neurotoxin, as such it should be handled with utmost care. When inhaled, the chemical can irritate the nose, throat, and lungs, causing wheezing and coughing.

The chemical is a corrosive substance, which may occur by ingestion. Contact of the chemical with the eyes and skin may cause pain, irritation, redness, and severe burns.

Chemical Properties

colourless liquid

Uses

Intermediate for weed killers.

Uses

  • 2-Chloropropionic acid is used in the preparation of propargyl 2-chloropropionate (PCP), an atom transfer radical polymerization (ATRP) initiator, by the esterification of propargyl alcohol.
  • It can be employed in the synthesis of a biologically active chitin derivative, (1-carboxyethyl) chitosan.
  • It can be treated with o-phenylenediamine phosphate to synthesize benzimidazole derivatives.

General Description

A pale liquid with a slight odor. Sinks in and mixes with water. Only aluminum, stainless steel or steel covered with a protective lining or coating may contact the liquid or vapor.

Air & Water Reactions

Water soluble.

Reactivity Profile

2-Chloropropionic acid is neutralized in exothermic reactions by all bases. Reacts with aqueous solutions containing a chemical base and dissolves if neutralization generates a soluble salt. May react with active metals to form gaseous hydrogen and a metal salt. May corrode or dissolve iron, steel, and aluminum parts and containers. Reacts with cyanide salts to generate gaseous hydrogen cyanide. Reacts with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides to generate flammable and/or toxic gases and heat. Reacts with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Reacts with carbonates and bicarbonates to generate a harmless gas (carbon dioxide) but some heat. Can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. May initiate polymerization reactions or catalyze other chemical reactions. Fire produces highly toxic chloride fumes [USCG, 1999].

Hazard

Combustible. Toxic by skin contact. Male reproductive damage.

Health Hazard

Harmful if inhaled. Irritating to throat. May cause severe skin and eye burns. Harmful if absorbed through skin.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

2-Chloropropionic acid on oral administration induces necrosis of granule cell layer of rat cerebellum.

Safety Profile

Poison by skin contact. A corrosive. Combustible when exposed to heat or flame. To fight fire, use water, foam, alcohol foam. When heated to decomposition it emits toxic fumes of Cl-. See also 3-CHLOROPROPIONIC ACID.

Purification Methods

Dry it with P2O5 and fractionally distil it under vacuum. [Beilstein 2 IV 745.]

2-Chloropropionic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloropropionic acid Suppliers

Zibo Chuanggu Chemical Technology Co., Ltd.
Tel
00-15864498288 15864498288
Email
15864498288@163.cn
Country
China
ProdList
43
Advantage
58
Changzhou Liren Medical Technology Co. Ltd.
Tel
0519-85859058 13915836899
Email
2078957504@qq.com
Country
China
ProdList
235
Advantage
58
Shanghai ideal Industrial Co., Ltd.
Tel
021-58957966 18930537195
Fax
021-60899437
Email
wouchina@126.com
Country
China
ProdList
3027
Advantage
58
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8843
Advantage
52
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
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View Lastest Price from 2-Chloropropionic acid manufacturers

R&D Scientific Inc.
Product
2-Chloropropionic acid 598-78-7
Price
US $1786.00/Kg
Min. Order
1Kg
Purity
97
Supply Ability
500 Kg
Release date
2024-09-03
Hebei Weibang Biotechnology Co., Ltd
Product
2-Chloropropionic acid 598-78-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-10-13
Hebei Mojin Biotechnology Co., Ltd
Product
2-Chloropropionic acid 598-78-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-24

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