(S)-(-)-2-Chloropropionic acid
- Product Name
- (S)-(-)-2-Chloropropionic acid
- CAS No.
- 29617-66-1
- Chemical Name
- (S)-(-)-2-Chloropropionic acid
- Synonyms
- 2-CHLOROPROPANOIC ACID;L-α-Chloropropionic acid;L-CPA;)-2-Chlo;(S)-()-2-Chlo;(s)-propanoicaci;L-2-CHLOROPROPINONICAL;S-(-)-2-Chloropropanoic;S-2-Chlorpropionic acid;l-2-chloropropanoicacid
- CBNumber
- CB3161267
- Molecular Formula
- C3H5ClO2
- Formula Weight
- 108.52
- MOL File
- 29617-66-1.mol
(S)-(-)-2-Chloropropionic acid Property
- Melting point:
- 4 °C
- Boiling point:
- 77 °C/10 mmHg (lit.)
- alpha
- -14.5 º (c=neat)
- Density
- 1.249 g/mL at 25 °C (lit.)
- vapor pressure
- 5hPa at 20℃
- refractive index
- n20/D 1.436
- Flash point:
- 140 °F
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- pka
- 2.83(at 25℃)
- form
- Liquid
- color
- Clear light yellow
- optical activity
- [α]25/D -14°, neat
- Water Solubility
- soluble
- BRN
- 1720257
- LogP
- 0.82 at 20.5℃
- CAS DataBase Reference
- 29617-66-1(CAS DataBase Reference)
- NIST Chemistry Reference
- (S)-(-)-2-chloropropionic acid(29617-66-1)
Safety
- Hazard Codes
- C
- Risk Statements
- 21/22-35-48/22
- Safety Statements
- 23-26-28-36/37/39-45
- RIDADR
- UN 2511 8/PG 3
- WGK Germany
- 1
- RTECS
- UA2451950
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29159080
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H290May be corrosive to metals
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P234Keep only in original container.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P390Absorb spillage to prevent material damage.
P405Store locked up.
P406Store in corrosive resistant/… container with a resistant inner liner.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C1373
- Product name
- (S)-(-)-2-Chloropropionic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $16
- Updated
- 2024/03/01
- Product number
- C1373
- Product name
- (S)-(-)-2-Chloropropionic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $29
- Updated
- 2024/03/01
- Product number
- L09427
- Product name
- (S)-(-)-2-Chloropropionic acid, 99%
- Packaging
- 5g
- Price
- $59.65
- Updated
- 2024/03/01
- Product number
- L09427
- Product name
- (S)-(-)-2-Chloropropionic acid, 99%
- Packaging
- 25g
- Price
- $164.65
- Updated
- 2024/03/01
- Product number
- C1373
- Product name
- (S)-(-)-2-Chloropropionic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $81
- Updated
- 2024/03/01
(S)-(-)-2-Chloropropionic acid Chemical Properties,Usage,Production
Description
(S)-2-chloropropanoic acid is a monocarboxylic acid that is propanoic acid substituted at position 2 by a chloro group (the S-enantiomer). It has a role as a neurotoxin. It is a monocarboxylic acid and a chlorocarboxylic acid. It is functionally related to propionic acid. It is a conjugate acid of a (S)-2-chloropropanoate.
Chemical Properties
Colourless Oil
Uses
Through the stereo displacement of (S)-(-)-2-Chloropropionic acid PPAR Agonist can be synthesized via asymmetric hydrogenation of a cinnamic acid derivative.
Definition
ChEBI: A monocarboxylic acid that is propanoic acid substitued at position 2 by a chloro group (the S-enantiomer).
General Description
2-Chloropropionic acid is an essential raw material for synthesising pesticides, dyes and medicines. Its application involves many sectors of the national economy and people's daily lives. It is an essential fine chemical product. In particular, (S)-(-)-2-Chloropropionic acid is a crucial intermediate for synthesising highly efficient and low-toxic aromatic oxygen propionic acid herbicides. For example, it can be used to synthesize (R)-2-(4-hydroxyphenoxy) propionic acid (ester) intermediates, fenthionyl, fenthionyl, fenthionyl, etc. At present, the preparation methods of (S)-(-)-2-chloropropionic acid and (R)-(+)-2-chloropropionic acid include: (1) chemical resolution method; (2) bioenzymatic resolution method; (3) chromatographic resolution method; (4) asymmetric synthesis method, etc.
Flammability and Explosibility
Non flammable
Synthesis
JP 061172846 provides a method for resolving racemic 2-chloropropionic acid using an optically active 2-aryl-2-isopropylethylamine as a resolving agent to obtain (S)-(-)-2-Chloropropionic acid (yield 24.2% and enantiomeric excess 83.2%). DE 4328231 provides a method for catalyzing the hydrolysis of 2-chloropropionic acid esters by a hydrolase (Pseudomonas Lipase) to hydrolyze (S)-2-chloropropionic acid esters to generate (S)-(-)-2-Chloropropionic acid.
Purification Methods
Purify the acid by fractionating twice through a 115cm Podbielniak column (p 11, calculated 50 theoretical plates at atmospheric pressure) using a take-off ratio of 1:5. The acid chloride is prepared by dissolving the acid in SOCl2, adding a few drops of PCl3, refluxing and then distilling through a 30cm column, b 53o/100mm, [] -4.6o (neat), d 1.2689, n1.4368. [Fu et al. J Am Chem Soc 76 6954 1954, Beilstein 2 IV 745.]
(S)-(-)-2-Chloropropionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-(-)-2-Chloropropionic acid manufacturers
- Product
- (S)-(-)-2-Chloropropionic acid 29617-66-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-19
- Product
- (S)-(-)-2-Chloropropionic acid 29617-66-1
- Price
- US $50.60/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 5000kg
- Release date
- 2024-08-20
- Product
- (S)-(-)-2-Chloropropionic acid 29617-66-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000kg
- Release date
- 2024-06-24