(S)-(-)-Methyl 2-chloropropionate

Product Name: (S)-(-)-Methyl 2-chloropropionate
CAS No.: 73246-45-4
Chemical Name: (S)-(-)-Methyl 2-chloropropionate
Synonyms: (S)-(-)-Methyl 2-chl;Methyl L-chloropropionate;Methyl 2-chloropropanoate;(S)-Methyl 2-chloropropanoate;Methyl (S)-2-Chloropropanoate;methyl (2S)-2-chloropropanoate;(S)-2-Chloropropionic acid methyl;(S)-(+)-METHYL 2-CHLOROPROPIONATE;METHYL (S)-(-)-2-CHLOROPROPIONATE;(-)-Methyl (S)-2-chloropropionate
CBNumber: CB2310312
Molecular Formula: C4H7ClO2
Formula Weight: 122.55
MOL File: 73246-45-4.mol

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(S)-(-)-Methyl 2-chloropropionate Property

Boiling point:: 80-82 °C110 mm Hg(lit.)
Density: 1.143 g/mL at 25 °C(lit.)
refractive index: n20/D 1.417(lit.)
Flash point:: 101 °F
storage temp.: -20°C
form: clear liquid
color: Colorless to Almost colorless
optical activity: [α]20/D 26°, neat
BRN: 1720589
InChI: InChI=1S/C4H7ClO2/c1-3(5)4(6)7-2/h3H,1-2H3/t3-/m0/s1
InChIKey: JLEJCNOTNLZCHQ-VKHMYHEASA-N
SMILES: C(OC)(=O)[C@@H](Cl)C
CAS DataBase Reference: 73246-45-4(CAS DataBase Reference)
NIST Chemistry Reference: Propanoic acid, 2-chloro-, methyl ester, (s)-(73246-45-4)
EPA Substance Registry System: Propanoic acid, 2-chloro-, methyl ester, (2S)- (73246-45-4)

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Safety

Hazard Codes: Xn
Risk Statements: 10-36-48/22
Safety Statements: 23-26-36
RIDADR: UN 2933 3/PG 3
WGK Germany: 1
F: 19
HazardClass: 3
PackingGroup: III
HS Code: 29159000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H319Causes serious eye irritation

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C1634
Product name: Methyl (S)-(-)-2-Chloropropionate
Purity: >98.0%(GC)
Packaging: 5g
Price: $157
Updated: 2025/07/31

AK Scientific

Product number: J53465
Product name: (S)-(-)-Methyl2-chloropropionate
Packaging: 1g
Price: $20
Updated: 2021/12/16

AK Scientific

Product number: Q529
Product name: (S)-(-)-Methyl2-chloropropionate
Packaging: 1g
Price: $27
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK373381
Product name: (S)-(-)-2-Chloropropionicacidmethylester
Purity: 98%
Packaging: 1g
Price: $32
Updated: 2021/12/16

Matrix Scientific

Product number: 126894
Product name: (S)-Methyl2-chloropropanoate
Purity: >95%
Packaging: 5g
Price: $68
Updated: 2021/12/16

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(S)-(-)-Methyl 2-chloropropionate Chemical Properties,Usage,Production

Uses

(-)-Methyl α-Chloropropionate is used in the preparation of TIPTP which is a therapeutic agent for rheumatoid arthritis.

Uses

Chiral starting material.

Synthesis

17392-83-5

73246-45-4

77287-29-7

Step I, preparation of Vilmerier reagent: 71.4 g (0.6 mol) of thionyl chloride was added to a 250 mL four-necked flask, cooled to 5~10°C in an ice-water bath, and 50.4 g (0.69 mol) of dry N,N-dimethylformamide was slowly added, the reaction was exothermic obviously, and mechanically stirred for 2 h to obtain a colorless Vilmerier reagent solution. Step II, Synthesis of methyl (S)-2-chloropropionate: a small amount of dioxane was added to the Vilmerier reagent solution obtained in Step I via a constant pressure dropping funnel at 20~30°C to form a mixed solution. Subsequently, 62.4 g (0.6 mol) of (R)-lactic acid methyl ester was slowly added dropwise to the mixed solution, and the reaction was markedly exothermic and gas was generated. After the dropwise addition, the reaction was continued with stirring and heated to 55°C for 6 h to obtain a solution of methyl (S)-2-chloropropionate. After the reaction was completed, the reaction mixture was cooled. Step III, post-treatment: the (S)-2-chloropropionic acid methyl ester solution obtained in Step II was washed, desolventized and distilled to obtain the product (S)-2-chloropropionic acid methyl ester 54.4 g, with 86% yield and 87% optical purity.

References

[1] Patent: CN103232344, 2016, B. Location in patent: Paragraph 0036-0039

(S)-(-)-Methyl 2-chloropropionate Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-2-(2,4-Dichlorophenoxy)propanoic acid

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(S)-(-)-Methyl 2-chloropropionate Suppliers

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View Lastest Price from (S)-(-)-Methyl 2-chloropropionate manufacturers

Career Henan Chemical Co

Product: (S)-(-)-Methyl 2-chloropropionate 73246-45-4
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-07-27

73246-45-4, (S)-(-)-Methyl 2-chloropropionateRelated Search:

ERBON DIISOPROPYL DICHLOROMALONATE (S)-(-)-Methyl 2-chloropropionate (S)-Isobutyl-2-chloropropanoate DIISOPROPYL CHLOROMALONATE Diethyl chloromalonate DALAPON-METHYL ESTER Dimethyl chloromalonate MECOPROP METHYL ESTER (R)-(+)-Methyl (R)-2-chloropropionate Methyl 2-acetylamino-3-chloropropionate Methyl 2,3-dichloropropionate Methyl 2-chloropropionate DICHLORPROP-METHYL ESTER Methyl 3-chloropropionate 2-Chloropropionic acid (S)-(-)-2-Chloropropionic acid N-ACETYL-2-CHLORO-2-DEOXYNEURAMINIC ACID METHYL ESTER 4,7,8,9-TETRAACETATE

2-chloro-,methylester,(s)-propanoicaci

Methyl 2-chloropropanoate

(S)-(-)-2-CHLOROPROPIONIC ACID METHYL ESTER

(S)-2-CHLOROPROPIONIC ACID METHYL ESTER

S-2-CHLOROPROPANOIC ACID METHYL ESTER

(S)-(+)-METHYL 2-CHLOROPROPIONATE

Methyl L-chloropropionate

L(-)-2-Chloropropionate methyl ester

(2S)-2-Chloropropanoic acid methyl ester

(S)-2-Chloropropionic acid methyl

(2S)-2-chloropropionic acid methyl ester

methyl (2S)-2-chloropropanoate

(S)-(-)-Methyl 2-chl

(S)-Methyl 2-chloropropanoate

Propanoic acid,2-chloro-, Methyl ester, (2S)-

METHYL (S)-(-)-2-CHLOROPROPIONATE

(-)-Methyl (S)-2-chloropropionate 99%

(S)-(-)-2-Chloropropionic acid methyl ester, 99%, ee: 98%

Methyl (S)-(-)-2-Chloropropionate &gt

(S)- methyl alpha-chloropropanoate

(-)-Methyl (S)-2-chloropropionate

Methyl (S)-2-Chloropropanoate

(?)-Methyl (<i>S</i>)-2-chloropropionate

(?)-Methyl (S)-2-chloropropionate

Methyl (S)-(-)-2-Chloropropionate, 98%min

73246-45-4

C4H7ClO2

CH3CHClCO2CH3

Asymmetric Synthesis

Esters

Organic Building Blocks

HALOGEN

Chiral Building Blocks

Esters (Chiral)

Esters

Organic Building Blocks

Chiral Building Blocks

Esters (Chiral)

Synthetic Organic Chemistry

Chiral Building Blocks

chiral

CHIRAL COMPOUNDS