ChemicalBook > CAS DataBase List > N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid

N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid

Product Name
N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid
CAS No.
103878-83-7
Chemical Name
N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid
Synonyms
TeMpiuM;Ro 19-6327/001;JMFKTFLARGGXCC-UHFFFAOYSA-N;N-(2-Aminoethyl)-5-chlor-2-pyridincarbox;N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid;N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride;2-PyridinecarboxaMide, N-(2-aMinoethyl)-5-chloro-, Monohydrochloride;ichemia,Lazabemide,DOPAC,MAO,radical generation,Ro 19-6327,disease,alzheimer′s,Inhibitor,inhibit,Lazabemide hydrochloride,Monoamine Oxidase,smoking cessation,parkinson
CBNumber
CB11448718
Molecular Formula
C8H10ClN3O.HCl
Formula Weight
0
MOL File
103878-83-7.mol
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N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Property

Melting point:
193-195°
storage temp. 
Desiccate at RT
solubility 
Soluble to 100 mM in water and to 100 mM in DMSO
form 
Powder
pka
8.9(at 25℃)
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Safety

Toxicity
LD50 orally in mice: 1000-2000 mg/kg (Imhof, Kyburz, 1986)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
L215258
Product name
LazabemideHydrochloride
Packaging
50mg
Price
$305
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003133
Product name
LAZABEMIDE HYDROCHLORIDE
Purity
95.00%
Packaging
10MG
Price
$648.83
Updated
2021/12/16
ApexBio Technology
Product number
B7064
Product name
Lazabemidehydrochloride
Packaging
50mg
Price
$795
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003133
Product name
LAZABEMIDE HYDROCHLORIDE
Purity
95.00%
Packaging
50MG
Price
$976.27
Updated
2021/12/16
ApexBio Technology
Product number
B7064
Product name
Lazabemidehydrochloride
Packaging
10mg
Price
$196
Updated
2021/12/16
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N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Chemical Properties,Usage,Production

Uses

Treatment of Alzheimer’s disease.

Uses

Lazabemide Hydrochloride is a reversible and selective inhibitor of MAO-A and MAO-B, both of which oxidatively deaminate neurotransmitter and xenobiotic amines.

Definition

ChEBI: Lazabemide hydrochloride is a pyridinecarboxamide.

brand name

Tempium (Hoffmann-LaRoche).

Biological Activity

Selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC 50 values are 0.03 and > 100 μ M for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC 50 values are 86, 123 and > 500 μ M for noradrenalin, serotonin and dopamine uptake respectively).

storage

Desiccate at RT

N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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China
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Beijing HuaMeiHuLiBiological Chemical
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010-56205725
Fax
010-65763397
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waley188@sohu.com
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China
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13621943973
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Career Henan Chemica Co
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Energy Chemical
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TargetMol Chemicals Inc.
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Nanjing Shizhou Biology Technology Co.,Ltd
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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103878-83-7, N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochloridRelated Search:


  • N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid
  • 2-PyridinecarboxaMide, N-(2-aMinoethyl)-5-chloro-, Monohydrochloride
  • Ro 19-6327/001
  • TeMpiuM
  • JMFKTFLARGGXCC-UHFFFAOYSA-N
  • N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride
  • N-(2-Aminoethyl)-5-chlor-2-pyridincarbox
  • ichemia,Lazabemide,DOPAC,MAO,radical generation,Ro 19-6327,disease,alzheimer′s,Inhibitor,inhibit,Lazabemide hydrochloride,Monoamine Oxidase,smoking cessation,parkinson
  • 103878-83-7
  • C8H10ClN3OHCl
  • Monoamine Oxidase