BOC-DL-2-AMINOBUTYRIC ACID

Product Name: BOC-DL-2-AMINOBUTYRIC ACID
CAS No.: 77284-64-1
Chemical Name: BOC-DL-2-AMINOBUTYRIC ACID
Synonyms: Boc-DL-2-Abu;Boc-2-aMinobutyric acid;DL-Boc-Aminobutyric acid;2-(Boc-amino)butyric Acid;BOC-DL-2-AMINOBUTYRIC ACID;2-(tert-butoxycarbonyl)butanoic acid;2-Aminobutanoic acid, N-BOC protected;2-[(tert-Butoxycarbonyl)amino]butanoic acid;(2R)-2-[(tert-butoxycarbonyl)amino]butanoate;Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-
CBNumber: CB1146853
Molecular Formula: C9H17NO4
Formula Weight: 203.24
MOL File: 77284-64-1.mol

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BOC-DL-2-AMINOBUTYRIC ACID Property

Melting point:: 60-62 °C
Boiling point:: 334.5±25.0 °C(Predicted)
Density: 1.101±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 4.00±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HazardClass: IRRITANT
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B699680
Product name: 2-[(tert-Butoxycarbonyl)amino]butanoicAcid
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Activate Scientific

Product number: AS87974
Product name: Boc-2-aminobutyric acid
Purity: 95+%
Packaging: 5G
Price: $86
Updated: 2021/12/16

Matrix Scientific

Product number: 048298
Product name: 2-[(tert-Butoxycarbonyl)amino]butanoic acid
Purity: >95%
Packaging: 500mg
Price: $112
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4158-1-14
Product name: 2-Aminobutanoic acid, N-Boc protected
Packaging: 500mg
Price: $184
Updated: 2021/12/16

Matrix Scientific

Product number: 048298
Product name: 2-[(tert-Butoxycarbonyl)amino]butanoic acid
Purity: >95%
Packaging: 1g
Price: $205
Updated: 2021/12/16

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BOC-DL-2-AMINOBUTYRIC ACID Chemical Properties,Usage,Production

Synthesis

24424-99-5

2835-81-6

77284-64-1

General procedure for the synthesis of N-Boc-DL-2-aminobutyric acid from di-tert-butyl dicarbonate and DL-2-aminobutyric acid: 10 g (96.97 mmol, 1.0 eq.) of DL-2-aminobutyric acid was dissolved in 65 mL of methanol to which 97 mL of sodium hydroxide (NaOH) solution was added. Subsequently, 25.4 g (116.37 mmol, 1.2 eq.) of di-tert-butyl dicarbonate (Boc2O) was slowly added at 0 °C. The reaction mixture was stirred at room temperature for 48 h. After completion of the reaction, it was concentrated under reduced pressure. The concentrated reaction mixture was adjusted pH to 2-3 with 1N HCl and then extracted with ethyl acetate. The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The residue was purified by column chromatography (SiO2, eluent gradient: hexane/ethyl acetate, 10:1 to hexane/ethyl acetate, 3:1) to afford 18.5 g of N-Boc-DL-2-aminobutyric acid (2-((tert-butoxycarbonyl)amino)butyric acid) as a colorless oil (91.02 mmol, 94% yield).1H NMR (300 MHz, CDCl3) δ 6.24 (s, 1H), 5.00-5.03 (d, 1H).

References

[1] Patent: US2018/105527, 2018, A1. Location in patent: Paragraph 0553-0556
[2] Catalysis Letters, 2017, vol. 147, # 4, p. 837 - 844

BOC-DL-2-AMINOBUTYRIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-DL-2-AMINOBUTYRIC ACID Suppliers

China 49 France 1 Germany 1 India 1 United Kingdom 2 United States 6 Global 60

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77284-64-1, BOC-DL-2-AMINOBUTYRIC ACIDRelated Search:

BOC-HYP(BZL)-OH BOC-LYS(TFA)-OH BOC-TRP-OSU Boc-O-(2-bromo-Cbz)-L-Tyrosine BOC-NVA-OH N-(tert-Butoxycarbonyl)-L-phenylalanine Boc-L-Glutamic acid BOC-L-Tyrosine BOC-ABU-OH BOC-L-NORLEUCINE Boc-Asp-OH BOC-L-Proline BOC-MET(O)-OH DL-2-Aminobutyric acid BOC-4-IODO-L-PHENYLALANINE BOC-D-TYR(2,6-DI-CL-BZL)-OH BOC-3,5-DIIODO-TYR(3'-BROMO-BZL)-OH BOC-ILE-OSU

2-Aminobutanoic acid, N-BOC protected

Boc-2-aMinobutyric acid

2-(tert-butoxycarbonyl)butanoic acid

BOC-DL-2-AMINOBUTYRIC ACID

Boc-DL-2-Abu

DL-Boc-Aminobutyric acid

2-[(tert-Butoxycarbonyl)amino]butanoic acid

Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-

(2R)-2-[(tert-butoxycarbonyl)amino]butanoate

2-(Boc-amino)butyric Acid

77284-64-1

pharmacetical