Fosaprepitant

Product Name: Fosaprepitant
CAS No.: 172673-20-0
Chemical Name: Fosaprepitant
Synonyms: L 758298;Fosaprepitant;Fosaprepitant D4;MK-0517 (Fosaprepitant);Fosaprepitant See F727305;Fosaprepitant (See also F727305);[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-2H-1,2,4-triazol-1-yl]phosphonic acid;[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid;P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic Acid;Phosphonic acid, P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-
CBNumber: CB11515191
Molecular Formula: C23H22F7N4O6P
Formula Weight: 614.41
MOL File: 172673-20-0.mol

More

Less

Fosaprepitant Property

Melting point:: >74°C (dec.)
Density: 1.65
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO, Methanol
pka: 2.45±0.20(Predicted)
form: Solid
color: White

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ApexBio Technology

Product number: B1272
Product name: Fosaprepitant
Packaging: 25mg
Price: $323
Updated: 2021/12/16

ApexBio Technology

Product number: B1272
Product name: Fosaprepitant
Packaging: 50mg
Price: $485
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134399
Product name: Fosaprepitant
Purity: >99%
Packaging: 100mg
Price: $510
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134399
Product name: Fosaprepitant
Purity: >99%
Packaging: 250mg
Price: $765
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134399
Product name: Fosaprepitant
Purity: >99%
Packaging: 1g
Price: $1504.5
Updated: 2021/12/16

More

Less

Fosaprepitant Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.

Uses

Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antagonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.

Uses

An antiemetic drug, a Aprepitant prodrug.

Definition

ChEBI: A morpholine derivative that is the (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl ether of (3-{[(2R,3S)-3-(4-fluorophenyl)-2-hydroxymorpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triaz l-1-yl)phosphonic acid.

Biological Activity

fosaprepitant (l-758,298 mk-0517) is an antagonist of neurokinin-1[1].fosaprepitant has shown the pharmacodynamic function by its active metabolite aprepitant. fosaprepitanot has been found to be a highly selective antagonist of the nk-1 receptor and inhibit the cation of substance p. in addition, fosaprepitant has been exhibited to have the effect on cisplatin induced emesis in the classical ferret model. besides, because of the brain penetrating of aprepitant, fosaprepitant has been revealed to have a very high affinity for the nk-1 receptor and increase the efficacy by dexamethasone, granisetron and so on. fosaprepitant has been evaluated to use in the prevention of chemotherapy-induced nausea and vomiting (cinv) by combination with a 5-ht3 antagonist and a steroid [1].

Drug interactions

Potentially hazardous interactions with other drugs
Antidepressants: avoid with St John’s wort.
Antipsychotics: avoid with pimozide.
Cytotoxics: possibly increases bosutinib concentration - avoid or reduce bosutinib dose.
Oestrogens and progestogens: may cause contraceptive failure.

Metabolism

Fosaprepitant is a prodrug and is rapidly metabolised to aprepitant. Aprepitant undergoes extensive hepatic metabolism, mainly via oxidation by the cytochrome P450 isoenzyme CYP3A4; the isoenzymes CYP1A2 and CYP2C19 mediate minor metabolic pathways. The resultant metabolites have weak activity and are excreted in the urine and in the faeces.

References

[1] van belle sj1, cocquyt v. fosaprepitant dimeglumine (mk-0517 or l-785,298), an intravenous neurokinin-1 antagonist for the prevention of chemotherapy induced nausea and vomiting.expert opin pharmacother. 2008 dec; 9(18):3261-70.

Fosaprepitant Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Fosaprepitant Suppliers

Canada 1 China 103 India 10 United States 9 Global 123

Chemvon Biotechnology Co., Ltd

Tel: 021-50790412
Fax: +86-21-50790419
Email: info@chemvon.com
Country: China
ProdList: 371
Advantage: 57

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Changzhou Kangte Pharmtech Co.,Ltd

Tel: 0519-82813797 18994752886
Fax: 0519-82813703
Email: czkangte@hotmail.com
Country: China
ProdList: 45
Advantage: 62

Shanghai Holy Biohemdeviser Co., Ltd

Tel: 021-61551100
Fax: 021-61551100
Country: China
ProdList: 444
Advantage: 57

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Wisdom Pharmaceutical Co., Ltd.

Tel: 0086-15189180296
Fax: 0086-513-81292226
Email: l_xu@wisdompharma.com
Country: China
ProdList: 221
Advantage: 60

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

More

Less

View Lastest Price from Fosaprepitant manufacturers

Hebei Mingeng Biotechnology Co., Ltd

Product: Fosaprepitant 172673-20-0
Price: US $200.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg/Month
Release date: 2022-11-24

Shijiazhuang Gantuo Biotechnology Co., Ltd

Product: Fosaprepitant 172673-20-0
Price: US $100.00/KG
Min. Order: 25KG
Purity: 99%
Supply Ability: 1000 Kilogram/Kilograms per Week
Release date: 2023-03-10

Wuhan Monad Medicine Tech Co.,LTD

Product: Fosaprepitant 172673-20-0
Price: US $10.00/KG
Min. Order: 1Kg/Bag
Purity: 99%min
Supply Ability: 20000
Release date: 2020-12-22

172673-20-0, FosaprepitantRelated Search:

Moroxydine hydrochloride Piracetam PHENYL VALERATE Diphenyl ether Moroxydine Dimethomorph Zolpidem tartrate Voriconazole PHENYL RESIN Fosaprepitant Impurity 9 Fosaprepitant Impurity 11 Fosaprepitant Impurity 17 Fosaprepitant Impurity 14 Aprepitant fosaprepitant dibenzyl ester Fosaprepitant Benzyl Ester Fosaprepitant dimeglumine Diphosphoric acid, tris(phenylmethyl) ester (9CI)

[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-2H-1,2,4-triazol-1-yl]phosphonic acid

[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid

L 758298

P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic Acid

MK-0517 (Fosaprepitant)

D-Glucitol, 1-deoxy-1-(MethylaMino)-, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4- Morpholinyl)Methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)phosphonate (2:1)

Fosaprepitant

Fosaprepitant (See also F727305)

Phosphonic acid, P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-

Fosaprepitant See F727305

Fosaprepitant D4

172673-20-0

C23H22F7N4O6P

Aromatics

Chiral Reagents

Intermediates & Fine Chemicals

Pharmaceuticals