ChemicalBook > CAS DataBase List > N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA

N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA

Product Name
N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
CAS No.
792173-99-0
Chemical Name
N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
Synonyms
CS-1891;SB334867/SB-334867;SB334867A free base;SB-334867,CID 6604926;SB-334867 (free base);SB-334867 >=98% (HPLC);N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl;N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA;Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-;N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
CBNumber
CB11519689
Molecular Formula
C17H13N5O2
Formula Weight
319.32
MOL File
792173-99-0.mol
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N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Property

Boiling point:
450.5±30.0 °C(Predicted)
Density 
1.472
storage temp. 
room temp
solubility 
insoluble in H2O; insoluble in EtOH; ≥14.55 mg/mL in DMSO
pka
10.21±0.43(Predicted)
form 
powder
color 
white to beige
CAS DataBase Reference
792173-99-0
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1530
Product name
SB-334867
Purity
≥98% (HPLC)
Packaging
5MG
Price
$131
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1530
Product name
SB-334867
Purity
≥98% (HPLC)
Packaging
25MG
Price
$530
Updated
2023/06/20
Cayman Chemical
Product number
19145
Product name
SB-334867
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
19145
Product name
SB-334867
Packaging
5mg
Price
$75
Updated
2024/03/01
Cayman Chemical
Product number
19145
Product name
SB-334867
Packaging
10mg
Price
$138
Updated
2024/03/01
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N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Chemical Properties,Usage,Production

Uses

SB 334867 is an orexin 1 receptor antagonist.

Definition

ChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative.

Biological Activity

sb-334867 free base is a selective antagonist of orexin-1 receptor [1].orexin-a and orexin-b are two peptides isolated from rat hypothalamus. they are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.sb-334867 free base could inhibit the orexin-a and orexin-b induced calcium responses in cho-ox1 cells with pkb values of 7.27 and 7.23, respectively. sb-334867 was more selective for ox1 receptor over ox2 receptor. it caused 32.7% and 22% inhibition of orexin-a and orexin-b induced calcium responses in cho-ox2 cells, respectively. moreover, sb-334867 was found to reduce both orexin-a-induced and fasting-induced food intake. the acute anorectic effect of it was associated with significant reductions in all active behaviours [1, 2].

Biochem/physiol Actions

Lateral hypothalamic orexin neuron activation leads to the development of morphine conditioned place preference, which is preferably blocked by SB-334867.

storage

Room temperature (desiccate)

References

[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452.

N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Suppliers

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792173-99-0, N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREARelated Search:

2,6-Dichlorobenzoxazole Thianaphthene 2-(P-TOLYL)BENZOXAZOLE 2-Methylbenzothiazole Quinazoline 6-Chloro-2-benzoxazolethiol 2-Phenylbenzoxazole

  • 1-(2-METHYL-1,3-BENZOXAZOL-6-YL)-3-(1,5-NAPHTHYRIDIN-4-YL)UREA
  • SB-334867,CID 6604926
  • SB334867/SB-334867
  • N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
  • 1-(2-methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea
  • SB-334867 (free base)
  • 1-(2-Methylbenzo[d]oxazol-5-yl)-3-(1,5-naphthyridin-4-yl)urea
  • N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-ylurea SB334867
  • N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl
  • CS-1891
  • SB334867A free base
  • Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-
  • SB-334867 >=98% (HPLC)
  • N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA USP/EP/BP
  • CHO,BEC,ethanol,intake,SB334867 free base,sucrose,Hypocretin Receptor,locomotor,cell,activity,SB334867A,Orexin Receptor (OX Receptor),SB 334867 free base,HCRT Receptor,inhibit,Inhibitor
  • N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
  • 792173-99-0
  • Inhibitors