ChemicalBook > CAS DataBase List > (S)-4-Chloro-3-hydroxybutyronitrile

(S)-4-Chloro-3-hydroxybutyronitrile

Product Name: (S)-4-Chloro-3-hydroxybutyronitrile
CAS No.: 127913-44-4
Chemical Name: (S)-4-Chloro-3-hydroxybutyronitrile
Synonyms: (S)-4-chloro-3-hydroxybutanenitrile;(S)-(-)-4-CHLORO-3-HYDROXYBUTYRONITRILE;(S)-4-Chloro-3-HCl;(S)-4-Chloro-3-hydro;(S)-4-Chloro-3-hydroxyb;oro-3-hydroxybutyronitriL;4-CHLORO-3-HYDROXY-BUTYRONITRILE;(S)-4-CHLORO-3-HYDROXYBUTYRONITRILE;(Z)-4-(chloromethylene)oxetan-2-one;(3S)-4-Chloro-3-hydroxybutyronitrile
CBNumber: CB1152621
Molecular Formula: C4H6ClNO
Formula Weight: 119.55
MOL File: 127913-44-4.mol

Less

(S)-4-Chloro-3-hydroxybutyronitrile Property

Boiling point:: 110 °C/1 mmHg(lit.)
Density: 1.250 g/mL at 20 °C(lit.)
refractive index: n20/D 1.474(lit.)
Flash point:: 110 °C
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
pka: 12.67±0.20(Predicted)
form: Oil
color: Clear Colourless
optical activity: Consistent with structure
InChI: InChI=1S/C4H6ClNO/c5-3-4(7)1-2-6/h4,7H,1,3H2/t4-/m0/s1
InChIKey: LHBPNZDUNCZWFL-BYPYZUCNSA-N
SMILES: C(#N)C[C@H](O)CCl
CAS DataBase Reference: 127913-44-4(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
HS Code: 29269090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: C3331
Product name: (S)-(-)-4-Chloro-3-hydroxybutyronitrile
Purity: >98.0%(GC)
Packaging: 1g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: C3331
Product name: (S)-(-)-4-Chloro-3-hydroxybutyronitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $35
Updated: 2025/07/31

TRC

Product number: C366605
Product name: (3S)-4-Chloro-3-hydroxybutyronitrile
Packaging: 1g
Price: $110
Updated: 2021/12/16

Apolloscientific

Product number: OR912506
Product name: (S)-4-Chloro-3-hydroxybutyronitrile
Purity: 98%
Packaging: 25g
Price: $131
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK167721
Product name: (S)-4-Chloro-3-hydroxybutyronitrile
Purity: 98%
Packaging: 1g
Price: $138
Updated: 2021/12/16

Less

(S)-4-Chloro-3-hydroxybutyronitrile Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

(3S)-4-Chloro-3-hydroxybutyronitrile is used in various organic precursor syntheses. It is used in the synthesis of hydroxypyrrolidinones to by used as carbapenem precursors. Also used in the preparation of atorvastatin (A791750) precursors. Impurity in the synthesis of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.

Synthesis

67843-74-7

143-33-9

127913-44-4

1. 75 L of water was added to the reactor followed by (S)-epichlorohydrin (99.3% ee). Under stirring conditions, 4.76 kg of 25% aqueous sodium cyanide and 3.30 kg of 50% aqueous citric acid were slowly added dropwise for 1 h. 2. The pH was maintained between 7.9 and 8 during the reaction, and the temperature was controlled at 22-25°C for 50 min. 3. After completion of the reaction, stirring was continued for 10 h. Then 0.7 kg of sodium chloride was added and stirred until it was The reaction mixture was extracted with 20 L of ethyl acetate and the organic layer was separated. 5. 0.2 kg of anhydrous sodium sulfate was added to the ethyl acetate layer, stirred for 30 min and filtered. 6. The ethyl acetate was removed by evaporation under reduced pressure, and the residue was distilled through a membrane distiller at 110°C/1 mbar to give 1.77 kg of (S)-4-chloro-3-hydroxybutanenitrile (Yield 91.3%, chemical purity 99.1%). 7. and 99.1% chemical purity).7. The optical purity of the product was determined to be 99.3% ee by GC analysis.8. The experiments were repeated under different reaction conditions according to the same method and the results are summarized in Table 1.

References

[1] Synthesis, 2004, # 16, p. 2629 - 2632
[2] Patent: WO2005/87715, 2005, A1. Location in patent: Page/Page column 9-10
[3] Patent: WO2005/87715, 2005, A1. Location in patent: Page/Page column 10
[4] Patent: WO2005/87715, 2005, A1. Location in patent: Page/Page column 10

(S)-4-Chloro-3-hydroxybutyronitrile Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(S)-4-Chloro-3-hydroxybutyronitrile Suppliers

Americas 1 Canada 1 China 284 Europe 2 France 1 Germany 2 India 3 Japan 2 Slovakia 1 South Korea 2 Switzerland 2 Ukraine 1 United Kingdom 7 United States 20 Global 329

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Jiangsu WNC Pharmaceutical Co.,Ltd

Tel: 13404202780
Email: 443631154@qq.com
Country: China
ProdList: 19
Advantage: 58

Tianjin Nuohan Chemical Co., Ltd.

Tel: 166-22132757 13802164402
Fax: QQ：1732062680
Email: zhuxuchen2016@yeah.net
Country: China
ProdList: 99
Advantage: 58

Jiangxi Sunway Chemical Co., Ltd.

Tel: 15888611133; 13566409786;18605760166
Email: trade@jxswchem.com
Country: China
ProdList: 15
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527621225
Email: 1791901229@qq.com
Country: China
ProdList: 6945
Advantage: 52

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

Beijing Taiya Jie Technology Development Co., Ltd.

Tel: 021-33690831-8001 13552411790
Fax: 021-33690831
Email: postmaster@tyjchem.cn
Country: China
ProdList: 1542
Advantage: 55

TaiZhou ZhiCheng Chemicals & Technology Co., LTD.

Tel: 0523-82837785 13914525028
Fax: 0523-87913272
Email: info@jszchg.com
Country: China
ProdList: 246
Advantage: 60

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2744
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Zouping Mingxing Chemical Co.,Ltd.

Tel: 86-13605431940 13605431940
Fax: 0086-0543-2240079
Email: zpmxchemical@126.com
Country: China
ProdList: 1490
Advantage: 62

Wuxi Zhangkun Biochemical Technology Co., Ltd.

Tel: +86 0510-85629785
Fax: +86 0510-85625359
Country: China
ProdList: 2327
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7782
Advantage: 58

Shanghai Hongbang Pharmaceutical Co., Ltd.

Tel: 021-021-64975436 18917636693
Fax: 021-24280809
Email: 1377976036@qq.com
Country: China
ProdList: 308
Advantage: 55

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3120
Advantage: 55

Huainan Kedi Chemical Factory

Tel: 0554-2106669
Fax: 0554-2666215
Email: sales1@kedichem.com
Country: China
ProdList: 4924
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 6295
Advantage: 60

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Quzhou Rundong Chemical (Technology) Co.

Tel: 0570-8789886 18892685668
Fax: 0570-8789985
Email: info@rundongchemical.com
Country: China
ProdList: 4053
Advantage: 60

Giant chemicals

Tel: 028-85434334 18108076537
Fax: QQ：245797092
Email: market@gianthx.com
Country: China
ProdList: 4505
Advantage: 56

Chengdu Research Accelerators Technology Co., Ltd.

Tel: 028-64353063
Fax: 028-64353063 QQ:784253935
Email: reacchemical@163.com
Country: China
ProdList: 5253
Advantage: 58

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 028-88469284 18000562381
Email: rzbtsj@163.com
Country: China
ProdList: 9951
Advantage: 56

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9279
Advantage: 55

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 6059
Advantage: 65

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 3495
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Less

View Lastest Price from (S)-4-Chloro-3-hydroxybutyronitrile manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (S)-4-Chloro-3-hydroxybutyronitrile 127913-44-4
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

WUHAN FORTUNA CHEMICAL CO., LTD

Product: (S)-4-Chloro-3-hydroxybutyronitrile 127913-44-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-13

Hebei Chuanghai Biotechnology Co., Ltd

Product: (S)-4-Chloro-3-hydroxybutyronitrile 127913-44-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-26

127913-44-4, (S)-4-Chloro-3-hydroxybutyronitrileRelated Search:

2,3,4-Trihydroxybenzoic acid D-(+)-Camphoric acid L-carnitine Levocarnitine iMpurity D(+)-CARNITINENITRILE CHLORIDE (R)-(-)-3-Chloro-1,2-propanediol (S)-(+)-3-Chloro-1,2-propanediol 4-Cyanophenol (R)-(+)-4-CHLORO-3-HYDROXYBUTYRONITRILE,(R)-4-CHLORO-3-HYDROXYBUTYRONITRILE acrylonitrile-butadiene rubber DL-Carnitine hydrochloride CROTONYLBETAINE(CARNITINE IMPURITY)(RG) (3-Carbamoylallyl)trimethylammonium PUKNFWRLBQXPFL-FXRZFVDSSA-N 2,2'-Azobis(2-methylpropionitrile) (4)-CHLORO-3-HYDROXYBUTYRONITRILE 98+%,γ-Chloro-β-hydroxybutyronitrile 2-Hexenoic acid, 4,5-dihydroxy- 2-Hexenoic acid, 4,5-dihydroxy-, (2E,4R,5S)-

4-CHLORO-3-HYDROXY-BUTYRONITRILE

(S)-(-)-4-CHLORO-3-HYDROXYBUTYRONITRILE

(S)-4-CHLORO-3-HYDROXYBUTYRONITRILE

(S)-(-)-4-CHLORO-3-HYDROXYBUTYRONITRILE, 97% (97% EE/GLC)

(S)-4-CHLORO-3-HYDROXYBUTYRONITRILE 98+%

(S)-4-chloro-3-hydroxybutanenitrile

(3S)-4-chloro-3-hydorxybutyronitrile

(3S)-4-Chloro-3-hydroxybutyronitrile

Butanenitrile,4-chloro-3-hydroxy-, (3S)-

(S)-(-)-4-Chloro-3-hydroxybutyronitrile, 97%, ee 98%

(S)-4-Chloro-3-hydro

S-(-)-4-chloro-3-hydorxy butyronitrile

(S)-4-Chloro-3-hydroxyb

oro-3-hydroxybutyronitriL

(S)-4-Chloro-3-hydroxybutyronitrile ISO 9001：2015 REACH

(S)-4-Chloro-3-HCl

Ats 3: S-(-)-4-Chloro-3-hydroxybutyronitrile

(S)-(-)-4-chloro-3-hydroxybutyroni-ril

(Z)-4-(chloromethylene)oxetan-2-one

127913-44-4

1279013-44-4

127913-44-5

C4H6ClNO

chiral

127913-44-4