3-Chloro-2-hydroxy-5-nitropyridine

Product Name: 3-Chloro-2-hydroxy-5-nitropyridine
CAS No.: 22353-38-4
Chemical Name: 3-Chloro-2-hydroxy-5-nitropyridine
Synonyms: 3-Chloro-5-nitro-2-pyridone;3-chloro-5-nitro-2-pyridinol;3-Chloro-2-Hydroxy-5-Picoline;3-CHLORO-5-NITRO-PYRIDIN-2-OL;5-nitro-2-hydroxy-3-chloropyridine;2-HYDROXY-3-CHLORO-5-NITROPYRIDINE;3-CHLORO-2-HYDROXY-5-NITROPYRIDINE;2(1H)-Pyridinone, 3-chloro-5-nitro-;2-Hydroxy-3-Chloro-5-Methyl Pyridine;3-Chloro-2-hydroxy-5-nitropyridine ,97%
CBNumber: CB1155248
Molecular Formula: C5H3ClN2O3
Formula Weight: 174.54
MOL File: 22353-38-4.mol

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3-Chloro-2-hydroxy-5-nitropyridine Property

Melting point:: 187-189°
Boiling point:: 286.1±40.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 6.58±0.10(Predicted)
color: White to Light yellow
InChI: InChI=1S/C5H3ClN2O3/c6-4-1-3(8(10)11)2-7-5(4)9/h1-2H,(H,7,9)
InChIKey: GTOXJMNILNYXLE-UHFFFAOYSA-N
SMILES: C1(=O)NC=C([N+]([O-])=O)C=C1Cl

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3185
Product name: 3-Chloro-5-nitro-2-pyridone
Purity: >98.0%(T)
Packaging: 1g
Price: $110
Updated: 2025/07/31

TRC

Product number: C384783
Product name: 3-Chloro-2-hydroxy-5-nitropyridine
Packaging: 1g
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 047115
Product name: 3-Chloro-5-nitro-2-pyridinol
Purity: 95+%
Packaging: 5g
Price: $28
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC55836
Product name: 3-Chloro-2-hydroxy-5-nitropyridine
Packaging: 2g
Price: $141
Updated: 2021/12/16

AK Scientific

Product number: W4607
Product name: 3-Chloro-2-hydroxy-5-nitropyridine
Packaging: 1g
Price: $73
Updated: 2021/12/16

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3-Chloro-2-hydroxy-5-nitropyridine Chemical Properties,Usage,Production

Uses

3-Chloro-2-hydroxy-5-nitropyridine is a nitropyridine analogue. It is used as a raw material for organic synthesis or as a pharmaceutical intermediate compound.

Synthesis

5418-51-9

22353-38-4

2-Hydroxy-5-nitropyridine (200 g, 1.42 mol) was added in batches to 800 mL of concentrated hydrochloric acid under constant stirring and subsequently heated to 50 °C. Aqueous sodium chlorate solution (80.0 g, 0.75 mol dissolved in an appropriate amount of water) was added slowly and dropwise. The reaction temperature was maintained at 50 °C with continued stirring for 1 h. The reaction was cooled to 0 °C upon completion. The precipitated solid product was collected by filtration, washed thoroughly with cold water and dried to give 2-hydroxy-3-chloro-5-nitropyridine. Yield: 240 g, 1.37 mol (96.0% yield). Melting point: 195-197 °C. 1H NMR (300 MHz, DMSO-d6): δ 8.65 (d, 1H, J = 2.5 Hz), 8.36 (d, 1H, J = 2.5 Hz). 13C NMR (300 MHz, DMSO-d6): δ 153.40, 144.29, 143.59, 135.08. 130.44. mass spectrum (ES): m/z 175 ([M + H]+).

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 58, p. 355 - 360
[2] Patent: WO2004/50637, 2004, A2. Location in patent: Page 66-67
[3] Synthesis, 1990, # 6, p. 499 - 501
[4] Patent: WO2014/115080, 2014, A1. Location in patent: Page/Page column 67; 68
[5] Patent: US6133253, 2000, A

3-Chloro-2-hydroxy-5-nitropyridine Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide N-Chlorosuccinimide 2-Hydroxy-5-nitropyridine

Preparation Products

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3-Chloro-2-hydroxy-5-nitropyridine Suppliers

Americas 1 China 103 Europe 1 France 1 Germany 2 India 27 Japan 1 Switzerland 2 United Kingdom 7 United States 22 Global 167

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View Lastest Price from 3-Chloro-2-hydroxy-5-nitropyridine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-CHLORO-2-HYDROXY-5-NITROPYRIDINE 22353-38-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-12

Dideu Industries Group Limited

Product: 3-CHLORO-2-HYDROXY-5-NITROPYRIDINE 22353-38-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-24

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Chloro-2-hydroxy-5-nitropyridine 22353-38-4
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100 MT
Release date: 2020-07-28

22353-38-4, 3-Chloro-2-hydroxy-5-nitropyridineRelated Search:

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2(1H)-Pyridinone, 3-chloro-5-nitro-

3-CHLORO-2-HYDROXY-5-NITROPYRIDINE ISO 9001：2015 REACH

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22353-38-4

Heterocycle-Pyridine series

Pyridine

Pyridines, Pyrimidines, Purines and Pteredines

Pyridines