4-Chloro-2-hydroxy-3-nitropyridine

Product Name: 4-Chloro-2-hydroxy-3-nitropyridine
CAS No.: 165547-79-5
Chemical Name: 4-Chloro-2-hydroxy-3-nitropyridine
Synonyms: 4-Chloro-3-nitropyridin-2-ol;4-Chloro-3-nitropyridin-2(1H)-one;2--3--4-;4-CHLORO-3-NITROPYRIDONE;4-CHLORO-3-NITRO-2-PYRIDONE;4-Chloro-3-nitro-1H-pyridin-2-one;4-Chloro-3-nitro-2(1H)-pyridinone;2-HYDROXY-3-NITRO-4-CHLOROPYRIDINE;4-Chloro-3-nitro-2-hydroxypyridine;4-Chloro-2-hydroxy-3-nitropyridine
CBNumber: CB1171958
Molecular Formula: C5H3ClN2O3
Formula Weight: 174.54
MOL File: 165547-79-5.mol

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4-Chloro-2-hydroxy-3-nitropyridine Property

Melting point:: 222-224°C
Boiling point:: 283.4±40.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: solid
pka: 6.89±0.10(Predicted)
color: Yellow
Water Solubility: Insoluble in water.
BRN: 149557
InChI: InChI=1S/C5H3ClN2O3/c6-3-1-2-7-5(9)4(3)8(10)11/h1-2H,(H,7,9)
InChIKey: UKIZCTHOMJXNIX-UHFFFAOYSA-N
SMILES: C1(=O)NC=CC(Cl)=C1[N+]([O-])=O
CAS DataBase Reference: 165547-79-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: C381863
Product name: 4-Chloro-3-nitropyridin-2-ol
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: C381863
Product name: 4-Chloro-3-nitropyridin-2-ol
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC55697
Product name: 4-Chloro-2-hydroxy-3-nitropyridine
Packaging: 2g
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC55697
Product name: 4-Chloro-2-hydroxy-3-nitropyridine
Packaging: 10g
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC55697
Product name: 4-Chloro-2-hydroxy-3-nitropyridine
Packaging: 5G
Price: $160
Updated: 2021/12/16

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4-Chloro-2-hydroxy-3-nitropyridine Chemical Properties,Usage,Production

Uses

4-Chloro-3-nitro-2-pyridone finds an important application as raw material in organic synthesis and pharmaceuticals. It is also used as an intermediate in agrochemicals and dyestuffs.

Synthesis

89282-12-2

165547-79-5

General procedure for the synthesis of 2-hydroxy-3-nitro-4-chloropyridine from 4-hydroxy-3-nitropyridin-2(1H)-one: to 2,4-dihydroxy-3-nitropyridine (5.00 g, 0.032 mol), dimethyl chloride (4.07 g, 0.032 mol), and 5 drops of DMF were added to 2,4-dihydroxy-3-nitropyridine (5.00 g, 0.032 mol) and slowly added dropwise to dichloromethane (80 mL) at 0°C. . The reaction mixture was stirred at room temperature for 4 hours. After the reaction was complete, it was diluted by adding dichloromethane (100 mL). The organic layer was washed sequentially with saturated sodium bicarbonate solution, water and saturated saline. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product 2-hydroxy-3-nitro-4-chloropyridine (5.00 g, 89% yield).

References

[1] Organic Process Research and Development, 2013, vol. 17, # 12, p. 1561 - 1567
[2] Patent: CN108498516, 2018, A. Location in patent: Paragraph 0023; 0025; 0026; 0027; 0028
[3] Patent: WO2017/14323, 2017, A1. Location in patent: Paragraph 0250
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 15, p. 4986 - 4989
[5] Patent: US2012/289497, 2012, A1. Location in patent: Page/Page column 29

4-Chloro-2-hydroxy-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-2-hydroxy-3-nitropyridine Suppliers

China 120 Germany 3 India 8 United Kingdom 3 United States 16 Global 150

Win-Win Chemical CO., Limited

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View Lastest Price from 4-Chloro-2-hydroxy-3-nitropyridine manufacturers

Honest Joy Holdings Limited

Product: 4-Chloro-2-hydroxy-3-nitropyridine 165547-79-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.6%
Supply Ability: 100 tons
Release date: 2022-02-08

Dideu Industries Group Limited

Product: 4-Chloro-2-hydroxy-3-nitropyridine 165547-79-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Chloro-2-hydroxy-3-nitropyridine 165547-79-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

165547-79-5, 4-Chloro-2-hydroxy-3-nitropyridineRelated Search:

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4-Chloro-2-hydroxy-3-nitropyridine

4-Chloro-3-nitro-2-hydroxypyridine

2--3--4-

4-Chloro-3-nitropyridin-2-ol

4-CHLORO-3-NITRO-2-PYRIDONE

4-CHLORO-3-NITROPYRIDONE

2-HYDROXY-3-NITRO-4-CHLOROPYRIDINE

2(1H)-Pyridinone, 4-chloro-3-nitro-

4-Chloro-3-nitro-1H-pyridin-2-one

4-Chloro-3-nitropyridin-2(1H)-one

4-Chloro-3-nitro-2(1H)-pyridinone

4-Chloro-2-hydroxy-3-nitropyridine ISO 9001：2015 REACH

2-Hydroxy-4-chloro-3-nitro pyridine

4-chloro-3-nitro-1H-pyridin-2-one - [C83492]

165547-79-5

Pyridine

Heterocycle-Pyridine series