ChemicalBook > CAS DataBase List > 2-HYDROXYMETHYL-4-BOC-MORPHOLINE

2-HYDROXYMETHYL-4-BOC-MORPHOLINE

Product Name: 2-HYDROXYMETHYL-4-BOC-MORPHOLINE
CAS No.: 135065-69-9
Chemical Name: 2-HYDROXYMETHYL-4-BOC-MORPHOLINE
Synonyms: TERT-BUTYL 2-(HYDROXYMETHYL)MORPHOLINE-4-CARBOXYLATE;2-Hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester;Viloxazine Impurity 3;Boc-2-hydroxymethyl-morpholine;4-Boc-2-hydroxymethyl-morpholine;2-HYDROXYMETHYL-4-BOC-MORPHOLINE;N-BOC-2-(HYDROXYMETHYL)MORPHOLINE;4-N-BOC-2-HYDROXYMETHYLMORPHOLINE;N-tert-Butoxycarbonyl-2-(hydroxymethyl)morpholine;tert-Butyl 2-(hydroxymethyl)-4-morpholinecarboxylate
CBNumber: CB1171695
Molecular Formula: C10H19NO4
Formula Weight: 217.26
MOL File: 135065-69-9.mol

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2-HYDROXYMETHYL-4-BOC-MORPHOLINE Property

Boiling point:: 320.7±27.0 °C(Predicted)
Density: 1.118±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Dichloromethane, Ether, Ethyl Acetate,
form: Oil
pka: 14.36±0.10(Predicted)
color: Colourless
CAS DataBase Reference: 135065-69-9(CAS DataBase Reference)

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Safety

HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H946480
Product name: 2-Hydroxymethylmorpholine-4-carboxylicAcidtert-ButylEster
Packaging: 25mg
Price: $115
Updated: 2021/12/16

TRC

Product number: H946480
Product name: 2-Hydroxymethylmorpholine-4-carboxylicAcidtert-ButylEster
Packaging: 250mg
Price: $925
Updated: 2021/12/16

Apolloscientific

Product number: OR912133
Product name: N-Boc-2-hydroxymethylmorpholine
Purity: 97%
Packaging: 5g
Price: $478
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1046284
Product name: 2-HYDROXYMETHYLMORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $496.74
Updated: 2021/12/16

Apolloscientific

Product number: OR912133
Product name: N-Boc-2-hydroxymethylmorpholine
Purity: 97%
Packaging: 1g
Price: $137
Updated: 2021/12/16

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2-HYDROXYMETHYL-4-BOC-MORPHOLINE Chemical Properties,Usage,Production

Chemical Properties

Colourless Oil

Uses

Intermediate in the preparation of racemic analogs of Viloxazine.

Synthesis

24424-99-5

40987-24-4

135065-69-9

GENERAL STEPS: Ammonium formate (3.04 g, 48.2 mmol) and 10% palladium/activated charcoal (500 mg) were added to a methanolic solution (50 mL) of (4-benzylmorpholin-2-yl)methanol (1.00 g, 4.82 mmol). The reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. The resulting residue was dissolved in acetonitrile (20 mL) and cooled in an ice bath. To this solution, di-tert-butyl dicarbonate (1.58 g, 7.23 mmol) and triethylamine (1.35 mL, 9.64 mmol) were added sequentially and the reaction mixture was stirred at room temperature for 3 hours. At the end of the reaction, the solvent was evaporated under reduced pressure, water was added to the residue and extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=5:1→1:1) to afford the target compound tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate (907 mg, 87% yield) as a colorless oil.1H NMR (400 MHz, DMSO-d6) δ 1.40 (9H, s), 2.47-2.66 (1H, m), and 2.73-2.92 (1H, m), 3.25-3.45 (4H, m), 3.70 (1H, d, J=13.4 Hz), 3.79 (1H, dd, J=11.6, 2.4 Hz), 3.85 (1H, d, J=12.8 Hz), 4.77 (1H, t, J=5.5 Hz).

References

[1] Patent: US2004/192653, 2004, A1
[2] Patent: EP1780210, 2007, A1. Location in patent: Page/Page column 55-56
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 17, p. 4080 - 4083

2-HYDROXYMETHYL-4-BOC-MORPHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-HYDROXYMETHYL-4-BOC-MORPHOLINE manufacturers

Honest Joy Holdings Limited

Product: tert-Butyl 2-(hydroxymethyl)morpholine-4-carboxylate 135065-69-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.4%
Supply Ability: 100 tons
Release date: 2022-01-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-HYDROXYMETHYL-4-BOC-MORPHOLINE 135065-69-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 2-HYDROXYMETHYL-4-BOC-MORPHOLINE 135065-69-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-15

135065-69-9, 2-HYDROXYMETHYL-4-BOC-MORPHOLINERelated Search:

(R)-N-Boc-2-Hydroxymethylmorpholine (S)-4-benzyl-2-(chloromethyl)morpholine 4-BENZYL-2-(CHLOROMETHYL)MORPHOLINE 4-BOC-2-MORPHOLINECARBALDEHYDE N-Boc-2-(2-hydroxyethyl)morpholine N-Boc-2-(2-Oxo-ethyl)-morpholine N-Boc-3-(2-Oxo-ethyl)-morpholine 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER tert-butyl 3-cyanomorpholine-4-carboxylate methylol cellulose 2-Hydroxymethylmorpholine (S)-N-Boc-2-Hydroxymethylmorpholine (R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid 2-HYDROXYMETHYL-4-BOC-MORPHOLINE 4-BOC-2-MORPHOLINECARBOXYLIC ACID 2-(S)-(TOLUENE-4-SULFONYLOXYMETHYL)-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 2-(R)-(TOLUENE-4-SULFONYLOXYMETHYL)-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 2-[(2-ETHOXY-PHENOXY)-PHENYL-METHYL]-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

TERT-BUTYL 2-(HYDROXYMETHYL)MORPHOLINE-4-CARBOXYLATE

N-BOC-2-(HYDROXYMETHYL)MORPHOLINE

2-HYDROXYMETHYL-4-BOC-MORPHOLINE

tert-Butyl 2-(hydroxymethyl)-4-morpholinecarboxylate

4-N-BOC-2-HYDROXYMETHYLMORPHOLINE

4-Boc-2-hydroxymethyl-morpholine

N-tert-Butoxycarbonyl-2-(hydroxymethyl)morpholine

2-Hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester

(R,S)-tert-Butyl 2-(hydroxymethyl)morpholine-4-carboxylate

4-Morpholinecarboxylic acid, 2-(hydroxyMethyl)-, 1,1-diMethylethyl ester

Boc-2-hydroxymethyl-morpholine

Viloxazine Impurity 3

135065-69-9

pharmacetical

Heterocycles series

Heterocycles

Intermediates

Heterocyclic Compounds

pharmaceutical