METHOXYCARBONYLSULFENYL CHLORIDE Property

Boiling point:

133-134 °C(lit.)

Density 

1.399 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.481(lit.)

Flash point:

130 °F

storage temp. 

2-8°C

solubility 

Miscible with dichlormethane.

form 

Liquid

Specific Gravity

1.399

color 

Clear bright yellow

Sensitive 

Moisture Sensitive

BRN 

1849908

InChIKey

TXJXPZVVSLAQOQ-UHFFFAOYSA-N

CAS DataBase Reference

26555-40-8(CAS DataBase Reference)

Safety

Hazard Codes 

C

Risk Statements 

10-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2920 8/PG 2

WGK Germany 

3

F 

10-21

HazardClass 

8

PackingGroup 

II

HS Code 

29309099

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

METHOXYCARBONYLSULFENYL CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

CLEAR BRIGHT YELLOW LIQUID

Uses

Methoxycarbonylsulfenyl chloride is used to prepare 3-[(methoxycarbonyl)dithio]-L-alanine by reacting with L-cysteine. Further, it is used in the synthesis of 3-2 pyridinyldithio propanoic acid hydrazide (PDPH). It serves as an important heterobifunctional crosslinker, which is a crosslinker used to make macromolecule-drug conjugates.

Uses

Methoxycarbonylsulfenyl chloride may be used to prepare 3-[(methoxycarbonyl)dithio]-L-alanine, via reaction with L-cysteine. It is suitable for use in the synthesis of 3-2 pyridinyldithio propanoic acid hydrazide (PDPH), an important heterobifunctional crosslinker widely used in bioconjugate techniques for making macromolecule-drug conjugates.

General Description

Methoxycarbonylsulfenyl chloride is a sulfenyl carbonyl compound. Photoinduced fragmentations of methoxycarbonylsulfenyl chloride is investigated in the gaseous phase by using synchrotron radiation and multicoincidence techniques. The molecular structure and conformational properties of methoxycarbonylsulfenyl chloride is studied in the gas and solid phases by gas electron diffraction, low-temperature X-ray diffraction and vibrational spectroscopy. The anomeric and mesomeric effects in methoxycarbonylsulfenyl chloride is reported.