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GALANIN (2-11) PORCINE, RAT

Product Name
GALANIN (2-11) PORCINE, RAT
CAS No.
367518-31-8
Chemical Name
GALANIN (2-11) PORCINE, RAT
Synonyms
AR-M 1896;GALANIN (2-11);Galanin (2-11) (AR-M 1896);GALANIN (2-11) PORCINE, RAT;TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2;H-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2;L-Leucinamide, L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-
CBNumber
CB1205136
Molecular Formula
C54H81N13O14
Formula Weight
1136.3
MOL File
367518-31-8.mol
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GALANIN (2-11) PORCINE, RAT Property

Boiling point:
1595.4±65.0 °C(Predicted)
Density 
1.291±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble to 1 mg/ml in 20% formic acid
pka
9.82±0.15(Predicted)
form 
lyophilized powder
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G8293
Product name
Galanin (2-11) porcine, rat
Purity
≥97% (HPLC), lyophilized powder
Packaging
500μG
Price
$564
Updated
2024/03/01
Alfa Aesar
Product number
J66796
Product name
Galanin (2-11)
Packaging
0.5mg
Price
$79.9
Updated
2021/12/16
Alfa Aesar
Product number
J66796
Product name
Galanin (2-11)
Packaging
1mg
Price
$131
Updated
2021/12/16
Usbiological
Product number
254662
Product name
AR-M 1896
Packaging
1mg
Price
$602
Updated
2021/12/16
ApexBio Technology
Product number
B5328
Product name
AR-M1896
Packaging
1mg
Price
$436
Updated
2021/12/16
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GALANIN (2-11) PORCINE, RAT Chemical Properties,Usage,Production

Biological Activity

binding ic50: 1.76 nm for rgalr2; 879 nm for hgalr1galanin is a 29-aa neuropeptide with a complex role in pain processing. galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution. three galanin receptors, galr1, galr2 and galr3, have been identified and cloned. ar-m1896 is a specific galanin r2 (galr2) agonist.

in vitro

additional removal of the glycine residue in position 1 resulted in ar-m1896 with almost unchanged galr2 affinity and functional activity, and 500-fold selectivity for galr2-rs over galr1-rs. this compound represents a truly galr2-selective galanin analog and, thus, could be used as a pharmacological tool to differentiate between these two receptors [1].

in vivo

in normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. the same effect is seen with equimolar doses of ar-m1896 or ar-m961 (an agonist both at galr1 and galr2 receptors). in allodynic bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high ar-m961dose, whereas no effect was observed in the control or ar-m1896 group. no effect of either compounds was observed in nonallodynic bennett model rats [1].

References

[1] liu hx, brumovsky p, schmidt r, brown w, payza k, hodzic l, pou c, godbout c, hökfelt t. receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via galr1 and galr2 receptors. proc natl acad sci u s a. 2001 aug 14;98(17):9960-4.

GALANIN (2-11) PORCINE, RAT Preparation Products And Raw materials

Raw materials

Preparation Products

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GALANIN (2-11) PORCINE, RAT Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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50
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
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Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
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68
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
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55
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9980
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Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303 +86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4840
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Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
6756
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
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View Lastest Price from GALANIN (2-11) PORCINE, RAT manufacturers

Career Henan Chemical Co
Product
Galanin (2-11) 367518-31-8
Price
US $1.00/KG
Min. Order
1g
Purity
Min98% HPLC
Supply Ability
g/kg /ton
Release date
2019-12-20

367518-31-8, GALANIN (2-11) PORCINE, RATRelated Search:


  • H-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2
  • GALANIN (2-11) PORCINE, RAT
  • AR-M 1896
  • GALANIN (2-11)
  • TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2
  • Galanin (2-11) (AR-M 1896)
  • L-Leucinamide, L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-
  • 367518-31-8
  • C54H81N13O14
  • Galanin receptor
  • Galanins
  • Neuropeptides
  • Peptides for Cell Biology