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GALANIN (2-11) PORCINE, RAT

Product Name
GALANIN (2-11) PORCINE, RAT
CAS No.
367518-31-8
Chemical Name
GALANIN (2-11) PORCINE, RAT
Synonyms
AR-M 1896;GALANIN (2-11);Galanin (2-11) (AR-M 1896);GALANIN (2-11) PORCINE, RAT;TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2;H-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2;L-Leucinamide, L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-
CBNumber
CB1205136
Molecular Formula
C54H81N13O14
Formula Weight
1136.3
MOL File
367518-31-8.mol
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GALANIN (2-11) PORCINE, RAT Property

Boiling point:
1595.4±65.0 °C(Predicted)
Density 
1.291±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble to 1 mg/ml in 20% formic acid
pka
9.82±0.15(Predicted)
form 
lyophilized powder
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G8293
Product name
Galanin (2-11) porcine, rat
Purity
≥97% (HPLC), lyophilized powder
Packaging
500μG
Price
$564
Updated
2024/03/01
Alfa Aesar
Product number
J66796
Product name
Galanin (2-11)
Packaging
0.5mg
Price
$79.9
Updated
2021/12/16
Alfa Aesar
Product number
J66796
Product name
Galanin (2-11)
Packaging
1mg
Price
$131
Updated
2021/12/16
Usbiological
Product number
254662
Product name
AR-M 1896
Packaging
1mg
Price
$602
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0003903
Product name
GALANIN (2-11) (PORCINE, RAT)
Purity
95.00%
Packaging
1MG
Price
$774.95
Updated
2021/12/16
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GALANIN (2-11) PORCINE, RAT Chemical Properties,Usage,Production

Biological Activity

binding ic50: 1.76 nm for rgalr2; 879 nm for hgalr1galanin is a 29-aa neuropeptide with a complex role in pain processing. galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution. three galanin receptors, galr1, galr2 and galr3, have been identified and cloned. ar-m1896 is a specific galanin r2 (galr2) agonist.

in vitro

additional removal of the glycine residue in position 1 resulted in ar-m1896 with almost unchanged galr2 affinity and functional activity, and 500-fold selectivity for galr2-rs over galr1-rs. this compound represents a truly galr2-selective galanin analog and, thus, could be used as a pharmacological tool to differentiate between these two receptors [1].

in vivo

in normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. the same effect is seen with equimolar doses of ar-m1896 or ar-m961 (an agonist both at galr1 and galr2 receptors). in allodynic bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high ar-m961dose, whereas no effect was observed in the control or ar-m1896 group. no effect of either compounds was observed in nonallodynic bennett model rats [1].

References

[1] liu hx, brumovsky p, schmidt r, brown w, payza k, hodzic l, pou c, godbout c, hökfelt t. receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via galr1 and galr2 receptors. proc natl acad sci u s a. 2001 aug 14;98(17):9960-4.

GALANIN (2-11) PORCINE, RAT Preparation Products And Raw materials

Raw materials

Preparation Products

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GALANIN (2-11) PORCINE, RAT Suppliers

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View Lastest Price from GALANIN (2-11) PORCINE, RAT manufacturers

Career Henan Chemical Co
Product
Galanin (2-11) 367518-31-8
Price
US $1.00/KG
Min. Order
1g
Purity
Min98% HPLC
Supply Ability
g/kg /ton
Release date
2019-12-20

367518-31-8, GALANIN (2-11) PORCINE, RATRelated Search:


  • H-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2
  • GALANIN (2-11) PORCINE, RAT
  • AR-M 1896
  • GALANIN (2-11)
  • TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2
  • Galanin (2-11) (AR-M 1896)
  • L-Leucinamide, L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-
  • 367518-31-8
  • C54H81N13O14
  • Galanin receptor
  • Galanins
  • Neuropeptides
  • Peptides for Cell Biology