ChemicalBook > CAS DataBase List > GALANIN (2-11) PORCINE, RAT
GALANIN (2-11) PORCINE, RAT
- Product Name
- GALANIN (2-11) PORCINE, RAT
- CAS No.
- 367518-31-8
- Chemical Name
- GALANIN (2-11) PORCINE, RAT
- Synonyms
- AR-M 1896;GALANIN (2-11);Galanin (2-11) (AR-M 1896);GALANIN (2-11) PORCINE, RAT;TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2;H-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2;L-Leucinamide, L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-
- CBNumber
- CB1205136
- Molecular Formula
- C54H81N13O14
- Formula Weight
- 1136.3
- MOL File
- 367518-31-8.mol
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GALANIN (2-11) PORCINE, RAT Property
- Boiling point:
- 1595.4±65.0 °C(Predicted)
- Density
- 1.291±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Soluble to 1 mg/ml in 20% formic acid
- form
- lyophilized powder
- pka
- 9.82±0.15(Predicted)
- biological source
- synthetic
- Sequence
- Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-NH2
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- G8293
- Product name
- Galanin (2-11) porcine, rat
- Purity
- ≥97% (HPLC), lyophilized powder
- Packaging
- 500μG
- Price
- $580
- Updated
- 2025/07/31
Usbiological
- Product number
- 254662
- Product name
- AR-M 1896
- Packaging
- 1mg
- Price
- $602
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B5328
- Product name
- AR-M1896
- Packaging
- 1mg
- Price
- $436
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- PEP0003903
- Product name
- GALANIN (2-11) (PORCINE, RAT)
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $774.95
- Updated
- 2021/12/16
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GALANIN (2-11) PORCINE, RAT Chemical Properties,Usage,Production
Uses
AR-M1896 is a GalR2 selective agonist with a binding IC50 of 1.76 nM for rat GalR2. AR-M1896 can be used for the research of acute myocardial infarction and neuropathic pain[1][2].
Biological Activity
binding ic50: 1.76 nm for rgalr2; 879 nm for hgalr1galanin is a 29-aa neuropeptide with a complex role in pain processing. galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution. three galanin receptors, galr1, galr2 and galr3, have been identified and cloned. ar-m1896 is a specific galanin r2 (galr2) agonist.
in vitro
additional removal of the glycine residue in position 1 resulted in ar-m1896 with almost unchanged galr2 affinity and functional activity, and 500-fold selectivity for galr2-rs over galr1-rs. this compound represents a truly galr2-selective galanin analog and, thus, could be used as a pharmacological tool to differentiate between these two receptors [1].
in vivo
in normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. the same effect is seen with equimolar doses of ar-m1896 or ar-m961 (an agonist both at galr1 and galr2 receptors). in allodynic bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high ar-m961dose, whereas no effect was observed in the control or ar-m1896 group. no effect of either compounds was observed in nonallodynic bennett model rats [1].
References
[1] liu hx, brumovsky p, schmidt r, brown w, payza k, hodzic l, pou c, godbout c, hökfelt t. receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via galr1 and galr2 receptors. proc natl acad sci u s a. 2001 aug 14;98(17):9960-4.
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View Lastest Price from GALANIN (2-11) PORCINE, RAT manufacturers
Career Henan Chemical Co
- Product
- Galanin (2-11) 367518-31-8
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- Min98% HPLC
- Supply Ability
- g/kg /ton
- Release date
- 2019-12-20
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