4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride
- Product Name
- 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride
- CAS No.
- 184475-55-6
- Chemical Name
- 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride
- Synonyms
- Gefitinib Hcl;Iressa hydrochloride;ZD-1839 hydrochloride;Gefitinib hydrochloride;Gefitinib hydrochloride salt;Gefitinib hydrochloride (ZD-1839 hydrochloride);4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride
- CBNumber
- CB12128725
- Molecular Formula
- C22H25Cl2FN4O3
- Formula Weight
- 483.37
- MOL File
- 184475-55-6.mol
4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; ≥4.28 mg/mL in H2O with gentle warming and ultrasonic; ≥6.9 mg/mL in DMSO with gentle warming
- form
- Powder
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- FG43011
- Product name
- Gefitinib hydrochloride
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- A3433
- Product name
- Gefitinibhydrochloride
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-1587
- Product name
- Gefitinib(hydrochloride)
- Purity
- 99.85%
- Packaging
- 500mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- CS-1587
- Product name
- Gefitinib(hydrochloride)
- Purity
- 99.85%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- A3433
- Product name
- Gefitinibhydrochloride
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride Chemical Properties,Usage,Production
Biological Activity
the egfr is a mr 170,000 transmembrane glycoprotein with an external binding domain and an intracellular tyrosine kinase domain. gefitinib (zd-1839, iressa) is an epidermal growth factor receptor-selective tyrosine kinase inhibitor.
in vitro
gefitinib inhibited colony formation in soft agar in a dose dependent manner in all cancer cell lines. however, treatment with higher doses resulted in a 2–4-fold increases in apoptosis. dose-dependent supra-additive increase in growth inhibition was observed when cancer cells were treated with totoxic drugs and gefitinib. the combined treatment markedly enhanced apoptotic cell death induced by single agent treatment [1].
in vivo
gefitinib treatment of nude mice bearing established human geo colon cancer xenografts revealed a reversible dose-dependent inhibition of tumor growth because geo tumors resumed the growth rate of controls at the end of the treatment [1].
target
| Target | Value |
| EGFR (Cell-free assay) | 15.5 nM |
| EGFR (858R/T790M) (Cell-free assay) | 823.3 nM |
References
[1] ciardiello f, caputo r, bianco r, damiano v, pomatico g, de placido s, bianco ar, tortora g. antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by zd-1839 (iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. clin cancer res. 2000;6(5):2053-63.
[2] cantarini mv, mcfarquhar t, smith rp, bailey c, marshall al. relative bioavailability and safety profile of gefitinib administered as a tablet or as a dispersion preparation via drink or nasogastric tube: results of a randomized, open-label, three-period crossover study in healthy volunteers. clin ther. 2004;26(10):1630-6.
4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride manufacturers
- Product
- Gefitinib 184475-55-6
- Price
- US $100.00/KG
- Min. Order
- 25KG
- Purity
- 99%
- Supply Ability
- 25tons
- Release date
- 2018-07-23