ChemicalBook > CAS DataBase List > 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride

4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride

Product Name
4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride
CAS No.
184475-55-6
Chemical Name
4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride
Synonyms
Gefitinib Hcl;Iressa hydrochloride;ZD-1839 hydrochloride;Gefitinib hydrochloride;Gefitinib hydrochloride salt;Gefitinib hydrochloride (ZD-1839 hydrochloride);4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride
CBNumber
CB12128725
Molecular Formula
C22H25Cl2FN4O3
Formula Weight
483.37
MOL File
184475-55-6.mol
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4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride Property

storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; ≥4.28 mg/mL in H2O with gentle warming and ultrasonic; ≥6.9 mg/mL in DMSO with gentle warming
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FG43011
Product name
Gefitinib hydrochloride
Packaging
250mg
Price
$70
Updated
2021/12/16
ApexBio Technology
Product number
A3433
Product name
Gefitinibhydrochloride
Packaging
250mg
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-1587
Product name
Gefitinib(hydrochloride)
Purity
99.85%
Packaging
500mg
Price
$72
Updated
2021/12/16
ChemScene
Product number
CS-1587
Product name
Gefitinib(hydrochloride)
Purity
99.85%
Packaging
1g
Price
$90
Updated
2021/12/16
ApexBio Technology
Product number
A3433
Product name
Gefitinibhydrochloride
Packaging
100mg
Price
$55
Updated
2021/12/16
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4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride Chemical Properties,Usage,Production

Biological Activity

the egfr is a mr 170,000 transmembrane glycoprotein with an external binding domain and an intracellular tyrosine kinase domain. gefitinib (zd-1839, iressa) is an epidermal growth factor receptor-selective tyrosine kinase inhibitor.

in vitro

gefitinib inhibited colony formation in soft agar in a dose dependent manner in all cancer cell lines. however, treatment with higher doses resulted in a 2–4-fold increases in apoptosis. dose-dependent supra-additive increase in growth inhibition was observed when cancer cells were treated with totoxic drugs and gefitinib. the combined treatment markedly enhanced apoptotic cell death induced by single agent treatment [1].

in vivo

gefitinib treatment of nude mice bearing established human geo colon cancer xenografts revealed a reversible dose-dependent inhibition of tumor growth because geo tumors resumed the growth rate of controls at the end of the treatment [1].

target

TargetValue
EGFR
(Cell-free assay)		 15.5 nM
EGFR (858R/T790M)
(Cell-free assay)		 823.3 nM

References

[1] ciardiello f, caputo r, bianco r, damiano v, pomatico g, de placido s, bianco ar, tortora g. antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by zd-1839 (iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. clin cancer res. 2000;6(5):2053-63.
[2] cantarini mv, mcfarquhar t, smith rp, bailey c, marshall al. relative bioavailability and safety profile of gefitinib administered as a tablet or as a dispersion preparation via drink or nasogastric tube: results of a randomized, open-label, three-period crossover study in healthy volunteers. clin ther. 2004;26(10):1630-6.

4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride manufacturers

Career Henan Chemical Co
Product
Gefitinib 184475-55-6
Price
US $100.00/KG
Min. Order
25KG
Purity
99%
Supply Ability
25tons
Release date
2018-07-23

184475-55-6, 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochlorideRelated Search:

p-Anisaldehyde Gefitinib CHLOROPHENYLSILANE 97 4,4'-DDT Imatinib Guaiacol Anisole 4-Methoxyphenol (Trifluoromethoxy)benzene POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE Topotecan hydrochloride 4-Methoxybenzyl cyanide p-Anisidine Difluorochloromethane Quinazoline 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride Methoxy

  • Gefitinib hydrochloride (ZD-1839 hydrochloride)
  • 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride
  • Gefitinib hydrochloride
  • Gefitinib Hcl
  • ZD-1839 hydrochloride
  • Iressa hydrochloride
  • Gefitinib hydrochloride salt
  • 184475-55-6
  • C22H25Cl2FN4O3
  • C22H24ClFN4O3HCl