ChemicalBook > CAS DataBase List > DISUCCINIMIDYL SUBERATE

DISUCCINIMIDYL SUBERATE

Product Name
DISUCCINIMIDYL SUBERATE
CAS No.
68528-80-3
Chemical Name
DISUCCINIMIDYL SUBERATE
Synonyms
DSS;DSS Crosslinker;Disuccinimidyl subera;DISUCCINIMIDYL SUBERATE;DSS Disuccinimidyl subera;Disuccinimidyl subera(DSS);DISUCCINIMIDYL OCTANEDIOATE;Di(N-succinimidyl) Suberate;Bis-(N-succinimidyl)-suberate;Di(N-succinimidyl)Suberate>
CBNumber
CB1219157
Molecular Formula
C16H20N2O8
Formula Weight
368.34
MOL File
68528-80-3.mol
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DISUCCINIMIDYL SUBERATE Property

Melting point:
169-170°C
Boiling point:
513.5±60.0 °C(Predicted)
Density 
1.295 g/cm3
storage temp. 
2-8°C
solubility 
chloroform: 50 mg/mL
form 
powder
color 
White to Almost white
Appearance
White solid
Water Solubility 
Insoluble in water. Soluble in chloroform: 50 mg/mL.
InChI
InChI=1S/C16H20N2O8/c19-11-7-8-12(20)17(11)25-15(23)5-3-1-2-4-6-16(24)26-18-13(21)9-10-14(18)22/h1-10H2
InChIKey
ZWIBGKZDAWNIFC-UHFFFAOYSA-N
SMILES
C(ON1C(=O)CCC1=O)(=O)CCCCCCC(ON1C(=O)CCC1=O)=O
CAS DataBase Reference
68528-80-3
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29171900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S1885
Product name
Suberic acid bis(N-hydroxysuccinimide ester)
Purity
≥95%, powder
Packaging
1g
Price
$136
Updated
2025/07/31
Sigma-Aldrich
Product number
S1885
Product name
Suberic acid bis(N-hydroxysuccinimide ester)
Purity
≥95%, powder
Packaging
5g
Price
$363
Updated
2025/07/31
TCI Chemical
Product number
D3895
Product name
Di(N-succinimidyl) Suberate
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$94
Updated
2025/07/31
TCI Chemical
Product number
D3895
Product name
Di(N-succinimidyl) Suberate
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$324
Updated
2025/07/31
Cayman Chemical
Product number
13008
Product name
Disuccinimidyl Suberate
Purity
≥98%
Packaging
50mg
Price
$11
Updated
2024/03/01
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DISUCCINIMIDYL SUBERATE Chemical Properties,Usage,Production

Description

DSS Crosslinker is a membrane permeable, noncleavable crosslinker. The NHS ester groups are reactive toward primary amines.

Uses

Disuccinimidyl suberate (DSS) is a bifunctional cross-linking reagent which contains two N-hydroxysuccinimide esters that are reactive toward primary amines. DSS is membrane-permeable and is commonly used to cross-link proteins in intact cells.

Uses

Disuccinimidyl suberate is a homobifunctional amine-reactive crosslinker. It is usually coupled to molecules containing primary amines via amide bonds buffered at pH 7.5 (6.5-8.5). It incorporates an 8-atom spacer arm.

Uses

Suberic acid bis(N-hydroxysuccinimide ester) has been:

  • supplemented in pierce lysis buffer used for immunoprecipitation
  • used to conjugate the oligonucleotide standards to gelatin
  • used in cross-linking of ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomers

General Description

Suberic acid bis(N-hydroxysuccinimide ester) is a homobifunctional cross-linking reagent with amine reactivity. Typically coupled to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). Suberic acid bis(N-hydroxysuccinimide ester) incorporates an 8-atom linker.

reaction suitability

reagent type: cross-linking reagent

IC 50

Non-cleavable Linker

DISUCCINIMIDYL SUBERATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DISUCCINIMIDYL SUBERATE Suppliers

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View Lastest Price from DISUCCINIMIDYL SUBERATE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
DISUCCINIMIDYL SUBERATE 68528-80-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
DISUCCINIMIDYL SUBERATE 68528-80-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Career Henan Chemical Co
Product
DISUCCINIMIDYL SUBERATE 68528-80-3
Price
US $1.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
200KG
Release date
2019-08-30

68528-80-3, DISUCCINIMIDYL SUBERATERelated Search:

BS3 1,2-DiMyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) SodiuM Salt Suberic acid Suberate Bis(sulfosuccinimidyl) Sodium Salt Disuccinimidyl glutarate EGS Crosslinker ETHYLENE GLYCOL DISUCCINATE BIS(SULFO-N- Glycolic acid Polysuccinimide Azelaic acid dihexyl octanedioate Trimethoxyoctylsilane 4-(MALEINIMIDO)PHENYL ISOCYANATE* 4-(N-Maleimido)benzophenone 2-Maleimido acetic acid DISUCCINIMIDYL SEBACATE 4-Maleimidobenzoic acid N-Succinimidyl maleimidoacetate

  • SUBERIC ACID BIS(N-HYDROXY-SUCCINIMIDE ESTER)
  • DSS Crosslinker
  • Di(<i>N</i>-succinimidyl) Suberate
  • DISUCCINIMIDYL OCTANEDIOATE
  • DISUCCINIMIDYL SUBERATE
  • DSS
  • n-hydroxysuccinimidesubericacidester
  • Bis-(N-succinimidyl)-suberate
  • Disuccinimidyl octanedioate, Disuccinimidyl suberate (DSS)
  • N,N'-[Hexamethylenebis(carbonyloxy)]bissuccinimide
  • Octanedioic acid bis(2,5-dioxopyrrolizino)
  • Suberic acid bis(2,5-dioxopyrrolizino)
  • Suberic acid bissuccinimidyl ester
  • Di(N-succinimidyl) Suberate
  • Disuccinimidyl suberate (DSS)
  • bis(2,5-dioxopyrrolidin-1-yl) octanedioate
  • suberic acid disuccinimido ester
  • Suberic acid bis(N-succinimidyl) ester
  • Di(N-hydroxysucciniMidyl) suberate
  • Suberic Acid Di(N-succinimidyl) Ester Di(N-succinimidyl) Octanedioate Octanedioic Acid Di(N-succinimidyl) Ester DSS
  • 2,5-Pyrrolidinedione, 1,1'-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis-
  • DSS Disuccinimidyl subera
  • Suberic acid bis(N-hydroxysuccinimide ester) >=95%, powder
  • Disuccinimidyl subera(DSS)
  • Di(N-succinimidyl)Suberate&gt
  • Disuccinimidyl subera
  • Octanedioic acid, 1,8-bis(2,5-dioxo-1-pyrrolidinyl) ester
  • Di(N-succinimidyl) Octanedioate
  • Octanedioic Acid Di(N-succinimidyl) Ester
  • Suberic Acid Di(N-succinimidyl) Ester
  • Bis(2,5-dioxo-1-pyrrolidinyl) Octanedioate
  • Disuccinimidyl suberate, cross-linking reagent
  • DSS Crosslinker, 10 mM in DMSO
  • Disuccinimidyl suberate Crosslinker
  • 68528-80-3
  • Proteomics
  • Proteomics and Protein Expression
  • Protein Modification
  • Homobifunctional Cross-Linking Reagents
  • Crosslinking
  • BioChemical
  • Homobifunctional Crosslinker
  • homoXlink
  • ADC LINKER