(R)-1-Boc-3-hydroxypyrrolidine

Product Name: (R)-1-Boc-3-hydroxypyrrolidine
CAS No.: 109431-87-0
Chemical Name: (R)-1-Boc-3-hydroxypyrrolidine
Synonyms: tert-butyl (R)-3-hydroxypyrrolidine-1-carboxylate;(R)-1-N-Boc-3-pyrrolidinol;(R)-TERT-BUTYL 3-HYDROXYPYRROLIDINE-1-CARBOXYLATE;tert-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate;tert-butyl (3S)-3-hydroxypyrrolidine-1-carboxylate;CAS:109431-87-0;Ivankasse impurity 18;(R)-1-BOC-3- Pyrolidinol;N-Boc-(R)-3-pyrrolidinol;(R)-1-BOC-3-PYRROLIDINOL
CBNumber: CB1232376
Molecular Formula: C9H17NO3
Formula Weight: 187.24
MOL File: 109431-87-0.mol

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(R)-1-Boc-3-hydroxypyrrolidine Property

Melting point:: 62-65 °C(lit.)
alpha: -7 º (c=1, MeOH)
Boiling point:: 273.3±33.0 °C(Predicted)
Density: 1.142±0.06 g/cm3(Predicted)
refractive index: -27 ° (C=1, MeOH)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: 14.74±0.20(Predicted)
form: Powder
color: White to off-white
optical activity: [α]20/D 26±1, c = 1 in methanol
InChI: InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h7,11H,4-6H2,1-3H3/t7-/m1/s1
InChIKey: APCBTRDHCDOPNY-SSDOTTSWSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC[C@@H](O)C1
CAS DataBase Reference: 109431-87-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-53-50-50/53
Safety Statements: 26-36
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 532169
Product name: (R)-(?)-N-Boc-3-pyrrolidinol
Purity: 98%
Packaging: 1g
Price: $21.36
Updated: 2025/07/31

Sigma-Aldrich

Product number: 532169
Product name: (R)-(?)-N-Boc-3-pyrrolidinol
Purity: 98%
Packaging: 5g
Price: $44.87
Updated: 2025/07/31

TCI Chemical

Product number: B3054
Product name: (R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol
Purity: >98.0%(GC)
Packaging: 1g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: B3054
Product name: (R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol
Purity: >98.0%(GC)
Packaging: 5g
Price: $108
Updated: 2025/07/31

TRC

Product number: B665905
Product name: (R)-1-N-Boc-3-pyrrolidinol
Packaging: 10g
Price: $155
Updated: 2021/12/16

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(R)-1-Boc-3-hydroxypyrrolidine Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Used in synthesis of ligands for the nicotinic acetylcholine receptor.

Synthesis

24424-99-5

40499-83-0

83220-73-9

1-tert-butoxycarbonyl-3-hydroxy-pyrrolidine (compound 16) was synthesized by a four-step reaction using di-tert-butyl dicarbonate and 3-hydroxy-pyrrolidine. First, (R)-3-pyrrolidinol (539 mg, 6.19 mmol) was converted to compound 16b to afford a colorless oily product (1.3 g, 100% yield). The spectral data of the product were consistent with the expected structure and in accordance with literature reports (see Kucznierz, R. et al., J. Med. Chem. 1998, 41, 4983-4994). Subsequently, compound 16b was further converted to compound 16c, again as a colorless oil. Next, compound 16c was converted by a two-step reaction to compound 16e, still a colorless oily substance. Finally, compound 16e was converted to the target product compound 16 to give a yellow oily substance.

References

[1] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 969 - 973
[2] Patent: WO2015/9731, 2015, A2. Location in patent: Paragraph 00106
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4983 - 4994
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 17, p. 5812 - 5832
[5] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 86

(R)-1-Boc-3-hydroxypyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-Boc-3-hydroxypyrrolidine Suppliers

Americas 1 Canada 2 China 298 Europe 3 Germany 6 India 10 Japan 3 South Korea 3 Switzerland 1 Ukraine 1 United Kingdom 12 United States 56 Global 396

AstaTech(Chengdu) Biopharmaceutical Corp.

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View Lastest Price from (R)-1-Boc-3-hydroxypyrrolidine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: (R)-1-Boc-3-hydroxypyrrolidine 109431-87-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-07-04

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-1-Boc-3-hydroxypyrrolidine 109431-87-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Shaanxi Dideu Medichem Co. Ltd

Product: (R)-(-)-N-Boc-3-pyrrolidinol 109431-87-0
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-27

109431-87-0, (R)-1-Boc-3-hydroxypyrrolidineRelated Search:

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BOC-(R)-3-HYDROXYPYRROLIDINE

(3R)-(-)-N-BOC-3-HYDROXYPYRROLIDINE

1-PYRROLIDINECARBOXYLIC ACID, 3-HYDROXY-, 1,1-DIMETHYLETHYL ESTER, (3R)-

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(R)-1-BOC-3- Pyrolidinol

tert-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate

tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylate, (3R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine

(R)-(-)-N-Boc-3-pyrrolidinol, ee: 98%

(R)-1-N-Boc-3-pyrrolidinol

(R)-N-Boc-3-hydroxypyrroline

tert-butyl (R)-3-hydroxypyrrolidine-1-carboxylate

(R)-N-Boc-3-hydroxypyrroline,99%e.e.

(R)-1-(Tert-Butoxycarbonyl)-3-

N-Boc-(R)-3-pyrrolidinol

(R)-1-Boc-3-pyrrolidinol (R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine (R)-1-Boc-3-hydroxypyrrolidine

(R)-(-)-N-Boc-3-pyrrolidinol 98%

(R)-1-N-Boc-hydroxypyrrolidine

(R)-(-)-N-Boc-3-pyrrolidinol, 98%, ee: 98%

N-(tert-Butoxycarbonyl)-(R)-3-hydroxypyrrolidine

(R)-1-Boc-3-hydroxypyrrolidine

(R)-1-(Tert-Butoxycarbonyl)

(3R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine

N-Boc-(R)-(-)-3-hydroxypyrrolidine

N-TERT-BUTOXYCARBONYL-(R)-(+)-3-PYRROLID

(R)-N-BOC-3-HYDROPYRROLIDINE

(3R)-(-)-N-BOC-3-HYDROXYPYROLIDINE

(S)-1-TERT-BUTOXYCARBONYL-3-PYRROLIDINOL

(R)-1-N-Boc-3-Hydroxypyrrolidi

N-t-Butoxycarbonyl-(R)-3-pyrro

tert-butyl (3S)-3-hydroxypyrrolidine-1-carboxylate

(r)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine

N-TERT-BUTOXYCARBONYL-(R)-(-)-3-PYRROLIDINOL

N-T-BOC-(R)-3-HYDROXYPYRROLIDINE

(R)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE-N-BOC

(R)-3-HYDROXYPYRROLIDINE, N-TERT-BUTOXYCARBONYL

(R)-1-BOC-3-PYRROLIDINOL

(R)-1-TERT-BUTOXYCARBONYL-3-PYRROLIDINOL

(R)-1-N-(T-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE

(R)-1-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE

(R)-1-N-BOC-3-HYDROXYPYRROLIDINE

(R)-N-BOC-3-PYRROLIDINOL

(R)-N-BOC-3-HYDROXY-PYRROLIDINE

(R)-N-BOC-3-HYDROXYPYRROLIDINE HYDROCHLORIDE

(R)-(-)-BOC-3-PYRROLIDINOL

(R)-TERT-BUTYL 3-HYDROXYPYRROLIDINE-1-CARBOXYLATE

(R)-N-tert-Butoxycarbonyl-(-)-3-pyrrolidinol

(R)-3-Hydroxypyrrolidine, N-BOC protected

(R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol &gt

C9H17NO3 (R)-(-)-N-Boc-3-pyrrolidinol 109431-87-0

China biggest manufacturer (R)-1-Boc-3-hydroxypyrrolidine 109431-87-0

Ivankasse impurity 18

(R)-1-Boc-3-hydroxypyrrolidine/ Evocalcet intermediate

R-N-tert.butylcarbonyl-3-pyrrolidinol

Bexagliflozin Impurity 19