ChemicalBook > CAS DataBase List > (R)-1-Boc-3-hydroxypyrrolidine

(R)-1-Boc-3-hydroxypyrrolidine

Product Name
(R)-1-Boc-3-hydroxypyrrolidine
CAS No.
109431-87-0
Chemical Name
(R)-1-Boc-3-hydroxypyrrolidine
Synonyms
tert-butyl (R)-3-hydroxypyrrolidine-1-carboxylate;(R)-1-N-Boc-3-pyrrolidinol;(R)-TERT-BUTYL 3-HYDROXYPYRROLIDINE-1-CARBOXYLATE;tert-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate;tert-butyl (3S)-3-hydroxypyrrolidine-1-carboxylate;CAS:109431-87-0;Ivankasse impurity 18;(R)-1-BOC-3- Pyrolidinol;N-Boc-(R)-3-pyrrolidinol;(R)-1-BOC-3-PYRROLIDINOL
CBNumber
CB1232376
Molecular Formula
C9H17NO3
Formula Weight
187.24
MOL File
109431-87-0.mol
More
Less

(R)-1-Boc-3-hydroxypyrrolidine Property

Melting point:
62-65 °C(lit.)
alpha 
-7 º (c=1, MeOH)
Boiling point:
273.3±33.0 °C(Predicted)
Density 
1.142±0.06 g/cm3(Predicted)
refractive index 
-27 ° (C=1, MeOH)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
14.74±0.20(Predicted)
form 
Powder
color 
White to off-white
optical activity
[α]20/D 26±1, c = 1 in methanol
InChI
InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h7,11H,4-6H2,1-3H3/t7-/m1/s1
InChIKey
APCBTRDHCDOPNY-SSDOTTSWSA-N
SMILES
N1(C(OC(C)(C)C)=O)CC[C@@H](O)C1
CAS DataBase Reference
109431-87-0(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-53-50-50/53
Safety Statements 
26-36
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
532169
Product name
(R)-(?)-N-Boc-3-pyrrolidinol
Purity
98%
Packaging
1g
Price
$21.36
Updated
2025/07/31
Sigma-Aldrich
Product number
532169
Product name
(R)-(?)-N-Boc-3-pyrrolidinol
Purity
98%
Packaging
5g
Price
$44.87
Updated
2025/07/31
TCI Chemical
Product number
B3054
Product name
(R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol
Purity
>98.0%(GC)
Packaging
1g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
B3054
Product name
(R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol
Purity
>98.0%(GC)
Packaging
5g
Price
$108
Updated
2025/07/31
TRC
Product number
B665905
Product name
(R)-1-N-Boc-3-pyrrolidinol
Packaging
10g
Price
$155
Updated
2021/12/16
More
Less

(R)-1-Boc-3-hydroxypyrrolidine Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Used in synthesis of ligands for the nicotinic acetylcholine receptor.

Synthesis

24424-99-5

40499-83-0

83220-73-9

1-tert-butoxycarbonyl-3-hydroxy-pyrrolidine (compound 16) was synthesized by a four-step reaction using di-tert-butyl dicarbonate and 3-hydroxy-pyrrolidine. First, (R)-3-pyrrolidinol (539 mg, 6.19 mmol) was converted to compound 16b to afford a colorless oily product (1.3 g, 100% yield). The spectral data of the product were consistent with the expected structure and in accordance with literature reports (see Kucznierz, R. et al., J. Med. Chem. 1998, 41, 4983-4994). Subsequently, compound 16b was further converted to compound 16c, again as a colorless oil. Next, compound 16c was converted by a two-step reaction to compound 16e, still a colorless oily substance. Finally, compound 16e was converted to the target product compound 16 to give a yellow oily substance.

References

[1] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 969 - 973
[2] Patent: WO2015/9731, 2015, A2. Location in patent: Paragraph 00106
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4983 - 4994
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 17, p. 5812 - 5832
[5] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 86

(R)-1-Boc-3-hydroxypyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(R)-1-Boc-3-hydroxypyrrolidine Suppliers

Americas 1 Canada 2 China 298 Europe 3 Germany 6 India 10 Japan 3 South Korea 3 Switzerland 1 Ukraine 1 United Kingdom 12 United States 56 Global 396
AstaTech(Chengdu) Biopharmaceutical Corp.
Tel
028-82666846 18080826311
Fax
QQ 2917178106
Email
sales@astatech.com.cn
Country
China
ProdList
499
Advantage
58
Wuxi Hailun Bio-Technology Co., Ltd.
Tel
0510-85629785 18051595327
Fax
0510-85625359
Email
sales@hlsw-bio.com
Country
China
ProdList
112
Advantage
58
BTC Pharmaceutical CO. Ltd
Tel
15716293042 18862996710
Fax
0513-68015394
Email
15050603958@163.com
Country
China
ProdList
695
Advantage
55
Ereal Chemical Co., Ltd.
Tel
0831-6888461 15181138905
Fax
QQ：97273224
Email
sales@erealchem.com
Country
China
ProdList
84
Advantage
55
Shanghai Hobor Chemical Co., Ltd
Tel
021-57790084; 13918007836
Fax
021-51685238
Email
sales@hoborchem.com
Country
China
ProdList
392
Advantage
60
Chengdu Firster Pharmaceutical Co., Ltd.
Tel
19138996873
Email
670603485@qq.com
Country
China
ProdList
173
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
zwchem@163.com
Country
China
ProdList
617
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Sichuan Guanghan Bio-Tech Co., Ltd
Tel
+86-28-86127071
Fax
+86-28-86127072
Email
info@sino-produce.com
Country
China
ProdList
406
Advantage
66
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768836
Email
1791901229@qq.com
Country
China
ProdList
6950
Advantage
52
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7471
Advantage
65
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
SpringPharma Tech Co.,Ltd
Tel
+86-25-68710855, +86-25-68710897
Fax
025-68710856
Email
sales@springpharma.net
Country
China
ProdList
1261
Advantage
62
Synches Co., Ltd.
Tel
021-53292253
Fax
021-53292253
Email
biz@synches.com
Country
China
ProdList
199
Advantage
64
Tongchuang Pharma(Suzhou). Co., Ltd.
Tel
0512-63263366 18912765016
Fax
0512-6326 3366
Email
tongtf110@sina.com
Country
China
ProdList
993
Advantage
62
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
Fax
027-8899 1911
Country
China
ProdList
1073
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Shijiazhuang suchen Chemical Technology Co. LTD
Tel
186-33933494 18032288352
Fax
0311-85310887
Email
1130239@qq.com
Country
China
ProdList
202
Advantage
60
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Syncozymes (Shanghai) Co.,Ltd.
Tel
021-68187180 13681683526
Fax
021-68187179
Email
lchen@syncozymes.com
Country
China
ProdList
317
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
15928766785 15928766785
Fax
QQ961458712
Email
wupengcheng@astatech.cn
Country
China
ProdList
1987
Advantage
55
Frandcom Industrial Limited
Tel
86-533-2151679
Fax
86-533-2151675
Email
info@frandcom.com
Country
China
ProdList
58
Advantage
58
Wuxi Zhangkun Biochemical Technology Co., Ltd.
Tel
+86 0510-85629785
Fax
+86 0510-85625359
Country
China
ProdList
2327
Advantage
58
AllyChem Co., Ltd.
Tel
0411-62313318 13942603642
Fax
0411-87549748
Email
info@allychem.com
Country
China
ProdList
1028
Advantage
65
More
Less

View Lastest Price from (R)-1-Boc-3-hydroxypyrrolidine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
(R)-1-Boc-3-hydroxypyrrolidine 109431-87-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-07-04
Henan Aochuang Chemical Co.,Ltd.
Product
(R)-1-Boc-3-hydroxypyrrolidine 109431-87-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29
Shaanxi Dideu Medichem Co. Ltd
Product
(R)-(-)-N-Boc-3-pyrrolidinol 109431-87-0
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-27

109431-87-0, (R)-1-Boc-3-hydroxypyrrolidineRelated Search:

N-Vinyl-2-pyrrolidone Pyrrolidine tert-Butanol 3-Pyrrolidinol tert-Butyl peroxyacetate N-Methyl-2-pyrrolidone tert-Butyl acetate Polyvinylpyrrolidone Povidone iodine (R)-1-BOC-2-METHYL-PYRROLIDINE (R)-N-Boc-3-aminomethylpiperidine N-Boc-L-alaninol 1-(tert-Butoxycarbonyl)-3-pyrrolidinol METHYL-2-PYRROLIDONE (R)-3-Hydroxypyrrolidine DL-3-PYRROLIDINOL (R)-1-Boc-3-hydroxypyrrolidine (2S,4R)-1-(tert-butoxycarbonyl)-4-[2-chloro-5-(trifluoromethyl)phenoxy]pyrrolidine-2-carboxylic acid

  • BOC-(R)-3-HYDROXYPYRROLIDINE
  • (3R)-(-)-N-BOC-3-HYDROXYPYRROLIDINE
  • 1-PYRROLIDINECARBOXYLIC ACID, 3-HYDROXY-, 1,1-DIMETHYLETHYL ESTER, (3R)-
  • (R)-1-N-BOC-3-Hhydroxypyrrolidine
  • R-1-N-Boc-3- hydroxy-pyrroline
  • (3R)-3-Hydroxypyrrolidine, N-BOC protected
  • (R)-(-)-N-BOC-3-pyrrolidinol,98%
  • 3-(R)-Hydroxy-pyrrolidine-1-carboxylicacidtert-butylester
  • (R)-1-BOC-3- Pyrolidinol
  • tert-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate
  • tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylate, (3R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine
  • (R)-(-)-N-Boc-3-pyrrolidinol, ee: 98%
  • (R)-1-N-Boc-3-pyrrolidinol
  • (R)-N-Boc-3-hydroxypyrroline
  • tert-butyl (R)-3-hydroxypyrrolidine-1-carboxylate
  • (R)-N-Boc-3-hydroxypyrroline,99%e.e.
  • (R)-1-(Tert-Butoxycarbonyl)-3-
  • N-Boc-(R)-3-pyrrolidinol
  • (R)-1-Boc-3-pyrrolidinol (R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine (R)-1-Boc-3-hydroxypyrrolidine
  • (R)-(-)-N-Boc-3-pyrrolidinol 98%
  • (R)-1-N-Boc-hydroxypyrrolidine
  • (R)-(-)-N-Boc-3-pyrrolidinol, 98%, ee: 98%
  • N-(tert-Butoxycarbonyl)-(R)-3-hydroxypyrrolidine
  • (R)-1-Boc-3-hydroxypyrrolidine
  • (R)-1-(Tert-Butoxycarbonyl)
  • (3R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine
  • N-Boc-(R)-(-)-3-hydroxypyrrolidine
  • N-TERT-BUTOXYCARBONYL-(R)-(+)-3-PYRROLID
  • (R)-N-BOC-3-HYDROPYRROLIDINE
  • (3R)-(-)-N-BOC-3-HYDROXYPYROLIDINE
  • (S)-1-TERT-BUTOXYCARBONYL-3-PYRROLIDINOL
  • (R)-1-N-Boc-3-Hydroxypyrrolidi
  • N-t-Butoxycarbonyl-(R)-3-pyrro
  • tert-butyl (3S)-3-hydroxypyrrolidine-1-carboxylate
  • (r)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine
  • N-TERT-BUTOXYCARBONYL-(R)-(-)-3-PYRROLIDINOL
  • N-T-BOC-(R)-3-HYDROXYPYRROLIDINE
  • (R)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE-N-BOC
  • (R)-3-HYDROXYPYRROLIDINE, N-TERT-BUTOXYCARBONYL
  • (R)-1-BOC-3-PYRROLIDINOL
  • (R)-1-TERT-BUTOXYCARBONYL-3-PYRROLIDINOL
  • (R)-1-N-(T-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE
  • (R)-1-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE
  • (R)-1-N-BOC-3-HYDROXYPYRROLIDINE
  • (R)-N-BOC-3-PYRROLIDINOL
  • (R)-N-BOC-3-HYDROXY-PYRROLIDINE
  • (R)-N-BOC-3-HYDROXYPYRROLIDINE HYDROCHLORIDE
  • (R)-(-)-BOC-3-PYRROLIDINOL
  • (R)-TERT-BUTYL 3-HYDROXYPYRROLIDINE-1-CARBOXYLATE
  • (R)-N-tert-Butoxycarbonyl-(-)-3-pyrrolidinol
  • (R)-3-Hydroxypyrrolidine, N-BOC protected
  • (R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol &gt
  • C9H17NO3 (R)-(-)-N-Boc-3-pyrrolidinol 109431-87-0
  • China biggest manufacturer (R)-1-Boc-3-hydroxypyrrolidine 109431-87-0
  • Ivankasse impurity 18
  • (R)-1-Boc-3-hydroxypyrrolidine/ Evocalcet intermediate
  • R-N-tert.butylcarbonyl-3-pyrrolidinol
  • Bexagliflozin Impurity 19