(R)-3-Hydroxypyrrolidine

Product Name: (R)-3-Hydroxypyrrolidine
CAS No.: 2799-21-5
Chemical Name: (R)-3-Hydroxypyrrolidine
Synonyms: (R)-PYRROLIDIN-3-OL;(3R)-Pyrrolidin-3-ol;R-HP;98%，ee99%;(R)-3-PYRROLIDINOL;(-)-3-Pyrrolidinol;(3R)-3-PYRROLIDINOL;3-PYRROLIDINOL, (R);(R)-Pyrrolidine-3-ol;R-(-)-3-PYRROLIDINOL
CBNumber: CB7494161
Molecular Formula: C4H9NO
Formula Weight: 87.12
MOL File: 2799-21-5.mol

More

Less

(R)-3-Hydroxypyrrolidine Property

Melting point:: 15°C
Boiling point:: 215-216 °C (lit.)
alpha: 6.5 º (c=3.5% in MeOH)
Density: 1.078 g/mL at 20 °C (lit.)
refractive index: n20/D 1.488(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Viscous Liquid
pka: 14.91±0.20(Predicted)
Specific Gravity: 1.048
color: Clear yellow to orange-brown
optical activity: [α]20/D +6.5°, c = 3.5 in methanol
Water Solubility: Soluble in water and methanol.
Sensitive: Air Sensitive & Hygroscopic
BRN: 5376132
InChI: 1S/C4H9NO/c6-4-1-2-5-3-4/h4-6H,1-3H2/t4-/m1/s1
InChIKey: JHHZLHWJQPUNKB-SCSAIBSYSA-N
SMILES: O[C@@H]1CCNC1
CAS DataBase Reference: 2799-21-5(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
F: 10-34
Hazard Note: Irritant
HS Code: 29339900
Storage Class: 10 - Combustible liquids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 382981
Product name: (R)-3-Pyrrolidinol
Purity: 98%
Packaging: 1g
Price: $85.4
Updated: 2023/01/07

Sigma-Aldrich

Product number: 382981
Product name: (R)-3-Pyrrolidinol
Purity: 98%
Packaging: 5g
Price: $137
Updated: 2023/01/07

TCI Chemical

Product number: P1608
Product name: (R)-3-Pyrrolidinol
Purity: >98.0%(GC)
Packaging: 1g
Price: $50
Updated: 2025/07/31

TCI Chemical

Product number: P1608
Product name: (R)-3-Pyrrolidinol
Purity: >98.0%(GC)
Packaging: 5g
Price: $151
Updated: 2025/07/31

TRC

Product number: P999130
Product name: (R)-Pyrrolidin-3-ol
Packaging: 1g
Price: $40
Updated: 2021/12/16

More

Less

(R)-3-Hydroxypyrrolidine Chemical Properties,Usage,Production

Chemical Properties

clear yellow to orange-brown viscous liquid

Uses

(R)-Pyrrolidin-3-ol is used in preparation of allosteric BCR-ABL bifunctional proteolysis targeting chimera compounds.

Synthesis

51-35-4

40499-83-0

The general procedure for the synthesis of 3-hydroxypyrrolidine from L-hydroxyproline is as follows: Example 1: Synthesis of (R)-3-pyrrolidinol To a 1 liter reaction vessel was added (4R)-hydroxy-L-proline (250 g, 1.907 mol), 2-cyclohexen-1-one (18.3 g, 0.1907 mol), and polyethylene glycol (750 mL, 400 average molar mass). The reaction was carried out by stirring the mixture under nitrogen protection at 150-160 °C. After 10 h, the reaction was judged complete when the reaction mixture changed from a suspension to a homogeneous phase. The yield of (R)-3-pyrrolidinol was 89.3% as determined by gas chromatographic analysis. Subsequently, the reaction solution was subjected to decompression distillation at the same temperature to collect fractions with boiling points of 100-120 °C (pressure 6-40 hPa) to give (R)-3-pyrrolidinol (120.4 g, 72.5% yield, 99.6% chemical purity, 99.9% optical purity ee).

Purification Methods

The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]

References

[1] Chemistry Letters, 1986, p. 893 - 896
[2] Patent: CN105153133, 2018, B. Location in patent: Paragraph 0022; 0023; 0024; 0025; 0026
[3] Synthetic Communications, 1993, vol. 23, # 19, p. 2691 - 2699
[4] Synthetic Communications, 1994, vol. 24, # 10, p. 1381 - 1387
[5] Patent: US2005/222430, 2005, A1. Location in patent: Page/Page column 2

(R)-3-Hydroxypyrrolidine Preparation Products And Raw materials

Raw materials

Xylene iodine Benzylamine Sodium borohydride Palladium Tetrahydrofuran Ethyl acetate Lithium Aluminum Hydride Dichloromethane Methanol D(+)-Malic acid

Preparation Products

More

Less

(R)-3-Hydroxypyrrolidine Suppliers

Americas 1 Belgium 2 Canada 2 China 216 Europe 1 France 1 Germany 6 India 8 Japan 12 South Korea 4 Switzerland 2 The Netherlands 1 United Kingdom 17 United States 48 Global 322

BTC Pharmaceutical CO. Ltd

Tel: 15716293042 18862996710
Fax: 0513-68015394
Email: 15050603958@163.com
Country: China
ProdList: 700
Advantage: 55

Anhui Dexinjia Biopharm Co., Ltd

Tel: 0531-82375893 15562613975
Email: 3416953599@qq.com
Country: China
ProdList: 300
Advantage: 58

Shanghai Hobor Chemical Co., Ltd

Tel: 021-57790084 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
Country: China
ProdList: 393
Advantage: 60

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2760
Advantage: 65

More

Less

View Lastest Price from (R)-3-Hydroxypyrrolidine manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: (R)-Pyrrolidin-3-ol 2799-21-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

Anhui Dexinjia Biopharm Co., Ltd

Product: (R)-3-Hydroxypyrrolidine 2799-21-5
Price: US $100.00/kg
Min. Order: 1kg
Purity: not less than 98%
Supply Ability: 20tons per month
Release date: 2025-05-06

Hebei Chuanghai Biotechnology Co., Ltd

Product: (R)-3-Hydroxypyrrolidine 2799-21-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

2799-21-5, (R)-3-HydroxypyrrolidineRelated Search:

N-Vinyl-2-pyrrolidone N-Methyl-2-pyrrolidone Polyvinylpyrrolidone 3-Pyrrolidinol Povidone iodine Pyrrolidine SCOPOLAMINE N-OXIDE HYDROBROMIDE METHYL-2-PYRROLIDONE Boc-Hyp-OH (2S,4R)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid RETRORSINE BOC-HYP(BZL)-OH CYTOCHALASIN A N-Cbz-Hydroxy-L-proline SWAINSONINE cis-4-Hydroxy-D-proline DIHYDROCYTOCHALASIN B CYTOCHALASIN E

(3R)-3-PYRROLIDINOL

(3R)-Pyrrolidin-3-ol

R-(+)-3-PYRROLIDINOL 98%

(R)-(+)-3-HYDROXYPYRROLIDINE , EE 99%

(R)-(+)-3-Hydroxypyrrolidine, 99%, ee 99%

(3R)-Pyrrolidine-3-ol

(R)-Pyrrolidine-3-ol

(R)-(+)-3-Pyrrolidinol,98%

(R)-Hydroxypyrrolidine

(R)-(+)-3-Pyrrolidiol

(3R)-3-Hydroxypyrrolidine

(R)-(+)-3-Pyrrolidinol, 98% 1GR

(R)-(+)-3-Pyrrolidinol, 98% 5GR

(R)-3-Hydroxypyrrolidine ,98%

(R)-pyrrolidin-3-ol (hydrobroMide)

3-Pyrrolidinol, (3R)-

(R)-3-Hydroxypyrrolidine ((R)-3-Pyrrolidinol)

98%，ee99%

(R) - four hydroxyl hydrogen pyrrole

(R)-(+)-3-Hydroxypyrrolidine,99%,ee99%

R-HP

(R)-(+)-3-PYRROLIDINOL

(R)-3-PYRROLIDINOL

R-(-)-3-PYRROLIDINOL

(R)-(+)-3-HYDROXYPYRROLIDINE

(R)-3-HYDROXYPYRROLIDINE

(R)-PYRROLIDIN-3-OL

(R)-3-Pyrrolidinol,99%e.e.

3-PYRROLIDINOL, (R)

(R)-3-Pyrrolidinol&gt

(R)-3-Hydroxypyrrolidine USP/EP/BP

(-)-3-Pyrrolidinol

(<i>R</i>)-3-Pyrrolidinol

2799-21-5

Asymmetric Synthesis

Simple Alcohols (Chiral)

Chiral Building Blocks

Heterocyclic Building Blocks

Pyrrolidines

pharmacetical

API intermediates

Chiral Building Blocks

Simple Alcohols (Chiral)

Synthetic Organic Chemistry