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OXOMEMAZINE

Product Name
OXOMEMAZINE
CAS No.
3689-50-7
Chemical Name
OXOMEMAZINE
Synonyms
Imakol;6847 RP;6487 RP;Dysedon;RP-6847;Doxergan;Dosegran;6847 R.P.;Oxomemazin;OXOEMAZINE
CBNumber
CB1236273
Molecular Formula
C18H22N2O2S
Formula Weight
330.44
MOL File
3689-50-7.mol
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OXOMEMAZINE Property

Melting point:
115°
Boiling point:
492.4±34.0 °C(Predicted)
Density 
1.1453 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Store at -20°C
solubility 
≥ 33mg/mL in DMSO
form 
Solid
pka
9.31±0.28(Predicted)
color 
White to off-white
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Safety

Toxicity
LD50 oral in mouse: 140mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
O860005
Product name
(±)-Oxomemazine
Packaging
1g
Price
$920
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009875
Product name
OXOMEMAZINE
Purity
95.00%
Packaging
1G
Price
$892.5
Updated
2021/12/16
ChemScene
Product number
CS-0131898
Product name
Oxomemazine
Packaging
10mg
Price
$60
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009875
Product name
OXOMEMAZINE
Purity
95.00%
Packaging
5MG
Price
$502.11
Updated
2021/12/16
Crysdot
Product number
CD11134460
Product name
Oxomemazine
Purity
97%
Packaging
1g
Price
$680
Updated
2021/12/16
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OXOMEMAZINE Chemical Properties,Usage,Production

Originator

Doxergan,Specia,France,1964

Uses

(±)-Oxomemazine, is a phenothiazine-type antihistamines, that has also shown antibacterial activity against Mycobacterium tuberculosis.

Definition

ChEBI: Oxomemazine is a member of phenothiazines.

Manufacturing Process

Phenothiazine is reacted with 3-dimethylamino-2-methylpropyl chloride in the presence of sodium amide to give 3-(10-phenthiazinyl)-2-methyl-1dimethylaminopropane. 11.9 g of of this intermediate is dissolved with agitation in glacial acetic acid (120 cc). Pure sulfuric acid (d = 1.83; 0.5 cc) is added and a mixture of glacial acetic acid (10 cc) and hydrogen peroxide (8.5 cc of a solution containing 38 g of hydrogen peroxide in 100 cc) is then run in over 20 minutes. The temperature rises from 25°C to 35°C and is then kept at 60°C for 18 hours. The mixture is cooled and water (150 cc) is added and, with cooling, aqueous sodium hydroxide (d = 1.33; 220 cc). The resulting mixture is extracted with ethyl acetate (3 x 100 cc), the solvent is evaporated on a water bath and the residue is recrystallized from heptane (150 cc). 3(9,9-dioxy-10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (78 g) is obtained, MP 115°C.
The corresponding hydrochloride prepared in ethyl acetate and recrystallized from a mixture of ethanol and isopropanol melts at 250°C.

Therapeutic Function

Antihistaminic

OXOMEMAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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OXOMEMAZINE Suppliers

Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
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View Lastest Price from OXOMEMAZINE manufacturers

Hebei Mingeng Biotechnology Co., Ltd
Product
Oxomemazine 3689-50-7
Price
US $200.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg/Month
Release date
2022-11-23
Shijiazhuang Gantuo Biotechnology Co., Ltd
Product
Oxomemazine 3689-50-7
Price
US $100.00/g
Min. Order
10g
Purity
99%
Supply Ability
1000g
Release date
2023-03-10

3689-50-7, OXOMEMAZINERelated Search:


  • OXOMEMAZINE
  • 10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine-5,5-dioxide
  • 10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-, 5,5-dioxide
  • 3-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N,2-trimethyl-1-propanamine
  • 6487 RP
  • 6847 R.P.
  • 6847 RP
  • Alimemazine S,S-dioxide
  • Dosegran
  • Doxergan
  • Dysedon
  • Imakol
  • Oxomemazin
  • Oxymemazine
  • Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-, 5,5-dioxide
  • RP-6847
  • S,S-Dioxo-9,9-(dimethylamino-3-methyl-2-propyl)-10-phenothiazine
  • Trimeprazine 5,5-dioxide
  • Oxomemazinebase
  • Oxomenazine
  • OXOEMAZINE
  • 10-(3-Dimethylamino-2-methylpropyl)-10H-phenothiazine 5,5-dioxide
  • 10-[2-(Dimethylaminomethyl)propyl]-10H-phenothiazine 5,5-dioxide
  • N,N,β-Trimethyl-10H-phenothiazine-10-propan-1-amine 5,5-dioxide
  • [3-(5,5-diketophenothiazin-10-yl)-2-methyl-propyl]-dimethyl-amine
  • 3-(5,5-dioxophenothiazin-10-yl)-N,N,2-trimethyl-propan-1-amine
  • 3-(5,5-dioxophenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
  • 10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-, 5,5-dioxide
  • OxomemazineQ: What is Oxomemazine Q: What is the CAS Number of Oxomemazine Q: What is the storage condition of Oxomemazine Q: What are the applications of Oxomemazine
  • histamine H1-receptor,OXOMEMAZINE,Histamine Receptor,inhibit,phenothiazine,antimuscarinic,muscarinic M1,Inhibitor,Metabotropic glutamate receptors,cough,anticholinergic,antihistamine,mGluR
  • 3689-50-7