Amsacrine

Product Name: Amsacrine
CAS No.: 51264-14-3
Chemical Name: Amsacrine
Synonyms: AMSA;CI-880;m-AMSA;C01553;Amekrin;Amsidyl;Amsakrin;AMSIDINE;Lamasine;SN 11841
CBNumber: CB1236394
Molecular Formula: C21H19N3O3S
Formula Weight: 393.46
MOL File: 51264-14-3.mol

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Amsacrine Property

Melting point:: 230-240 °C
Boiling point:: 563.0±60.0 °C(Predicted)
Density: 1.2205 (rough estimate)
refractive index: 1.6740 (estimate)
storage temp.: 2-8°C(protect from light)
solubility: Soluble in DMSO
form: Powder
pka: 8.55±0.10(Predicted)
color: Orange to red
CAS DataBase Reference: 51264-14-3
IARC: 2B (Vol. 76) 2000

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Safety

RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 51264-14-3(Hazardous Substances Data)
Toxicity: LD50 in male, female CDF1 mice: 810 mg/m2; 729 mg/m2 orally (Pavkov)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A898095
Product name: Amsacrine
Packaging: 50mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-1942
Product name: Amsacrine
Purity: 99.98%
Packaging: 100mg
Price: $140
Updated: 2021/12/16

ApexBio Technology

Product number: B1302
Product name: Amsacrine
Packaging: 25mg
Price: $156
Updated: 2021/12/16

ApexBio Technology

Product number: B1302
Product name: Amsacrine
Packaging: 50mg
Price: $179
Updated: 2021/12/16

ChemScene

Product number: CS-1942
Product name: Amsacrine
Purity: 99.98%
Packaging: 500mg
Price: $220
Updated: 2021/12/16

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Amsacrine Chemical Properties,Usage,Production

Description

Amsacrine is a cytostatic reported to be active against adult lymphoblastic leukemia which has failed primary treatment or become resistant. Its clinical use, however, is associated with significant neuro-, gastro- and hepatotoxicity.

Originator

Auckland Cancer Chemotherapy Lab (New Zealand)

Uses

Amsacrine (Amsidyl) is used as an Investigational drug.

Uses

Amsacrine is a drug undergoing intensive trials for severe leukemia and lymphoma. It is a cytotoxic drug that binds with DNA with expressed specificity to the adenosine–tyrosine pair, thus inhibiting DNA synthesis. It has been suggested to be used for severe leukemia. A synonym of this drug is amsidyl.

Uses

Antineoplastic.

Definition

ChEBI: A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

brand name

Amsidyl (Parke-Davis);Amsakrin.

Synthesis

Amsacrine, 4-(9-acridinylamino)-3-methoxyphenyl-N-methansulfonamide (30.6.11), is made by sulfonating 4-nitro-m-anisidine with methanesulfonyl chloride, which forms a sulfonyl amide 30.6.9, and the nitro group is reduced to an amino group by hydrogen, forming 4-amino-3-methoxyphenyl-N-methansulfonamide (30.6.10). Reacting this with 9-chloroacridine gives amsacrine (30.6.11).

References

[1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5.

Amsacrine Preparation Products And Raw materials

Raw materials

Methanesulfonamide Amsacrine hydrochloride Methanesulfonyl chloride 9-Chloroacridine 4-Nitroaniline

Preparation Products

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Amsacrine Suppliers

China 92 Germany 1 India 5 Switzerland 1 United States 15 Global 114

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Abblis Chemicals LLC

Tel: +1-832-373-8299
Fax: +1-713-664-0347
Email: info@abblis.com
Country: United States
ProdList: 323
Advantage: 57

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

TargetMol Chemicals Inc.

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Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Aladdin Scientific

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Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
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ApexBio Technology

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ProdList: 6251
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Abcam

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ProdList: 6001
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MedChemExpress

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Country: United States
ProdList: 6398
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Alfa Chemistry

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Country: United States
ProdList: 6814
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LKT Laboratories, Inc.

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Country: United States
ProdList: 2164
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Waterstone Technology, LLC

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Country: United States
ProdList: 6786
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AK Scientific, Inc.

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EMD Biosciences, Inc.

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Country: United States
ProdList: 6529
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View Lastest Price from Amsacrine manufacturers

Dideu Industries Group Limited

Product: Amsacrine 51264-14-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-01

Shaanxi Dideu Medichem Co. Ltd

Product: Amsacrine 51264-14-3
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 800 tons
Release date: 2020-04-29

Career Henan Chemical Co

Product: Amsacrine 51264-14-3
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

51264-14-3, AmsacrineRelated Search:

2-ETHOXY-6,9-DIAMINOACRIDINE Sulfanilamide Quinacridone 9(10H)-ACRIDONE m-Phenylenediamine 4-Methoxyphenylacetone 6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE PHENYL VALERATE Tamoxifen Basic Orange 14 3-Aminobenzenesulfonamide p-Phenylenediamine o-Phenylenediamine Phenylacetic acid Phenylpropanolamine Amsacrine hydrochloride CI 921 Amsacrine

M-AMSA, HCL

M-AMSA HYDROCHLORIDE

N-[4-(Acridin-9-ylamino)-3-(methyloxy)phenyl]methanesulfonamide

Amekrin

Amsakrin

Amsidyl

CI-880

4'-(9-Acridinylamino)methanesulfon-m-anisidide

AMSIDINE

META-AMSA

Amsacrine/Amsacrine hydrochloride

acridinyl anisidide

AMSA;M-AMSA;CI-880;SN-11841;ACRIDINYL ANISIDIDE

Lamasine

m-AMSA

N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide

Amsacrine

4'-(9-Acridinylamino)-3'-methoxymethanesulfonanilide

C01553

N-[4-(acridin-9-ylmethyl)-3-methoxyphenyl]methanesulfonamide

SN 11841

MethanesulfonaMide,N-[4-(9-acridinylaMino)-3-Methoxyphenyl]-

NSC-156303

NSC-249992：SN-11841

AMSA

N-[4-(Acridin-9-yl)amino-3-methoxyphenyl]methanesulfonamide

NSC-249992

m-AMSA Solution

Amsacrine USP/EP/BP

Amsacrine, DNA topoisomerase II inhibitor

51264-14-3

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Apoptosis and Cell Cycle

DNA Repair Regulators

DNA metabolism

Pharmaceutical material and intermeidates