ChemicalBook > CAS DataBase List > tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate

tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate

Product Name
tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
CAS No.
112741-50-1
Chemical Name
tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
Synonyms
(2S,3R)-tert-Butyl;(5R,6S)-N-Boc-5,6-diphenyl-2-morpholinone;6-oxo-2,3-diphenylMorpholine-4-carboxylate;(2S,3R)-(+)-N-Boc-6-oxo-2,3-diphenylMorpholine;2S,3R-6-oxo-2,3-diphenyl-4-morpholinecarboxylate;tert-butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morph;(2S,3R)-6-oxo-2,3-diphenylmorpholine-4-carboxylate;(5S,6R)-(+)-4-Boc-5,6-diphenyl-2-Morpholinone, 99%;(5R,6S)-4-TERT-BUTOXYCARBONYL-5,6-DIPHENYLMORPHOLIN-2-ONE;(5S,6R)-4-tert-Butoxycarbonyl-5,6-diphenylmorpholin-2-one
CBNumber
CB1239496
Molecular Formula
C21H23NO4
Formula Weight
353.41
MOL File
112741-50-1.mol
More
Less

tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Property

Melting point:
206 °C (dec.)(lit.)
alpha 
86 º (c=5.5 in methylene chloride)
Boiling point:
509.6±50.0 °C(Predicted)
Density 
1.175±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
soluble in THF, CH2Cl2
pka
-3.28±0.60(Predicted)
optical activity
[α]20/D +86°, c = 5.5 in methylene chloride
InChIKey
MRUKRSQUUNYOFK-MOPGFXCFSA-N
CAS DataBase Reference
112741-50-1(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
331813
Product name
(2S,3R)-(+)-N-Boc-6-oxo-2,3-diphenylmorpholine
Purity
99%
Packaging
5g
Price
$441
Updated
2023/06/20
Sigma-Aldrich
Product number
331813
Product name
(2S,3R)-(+)-N-Boc-6-oxo-2,3-diphenylmorpholine
Purity
99%
Packaging
1g
Price
$97.8
Updated
2023/01/07
TRC
Product number
B699835
Product name
(2S,3R)-(+)-N-Boc-6-oxo-2,3-diphenylmorpholine
Packaging
500mg
Price
$140
Updated
2021/12/16
TRC
Product number
B699835
Product name
(2S,3R)-(+)-N-Boc-6-oxo-2,3-diphenylmorpholine
Packaging
2.5g
Price
$360
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB63306
Product name
(2S,3R)-tert-Butyl 6-oxo-2,3-diphenylmorpholine-4-carboxylate
Packaging
5G
Price
$825
Updated
2021/12/16
More
Less

tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Chemical Properties,Usage,Production

Uses

(2S,3R)-(+)-N-Boc-6-oxo-2,3-diphenylmorpholine (Williams chiral auxiliary) can be used as a reactant:

  • In the asymmetric synthesis of cylindrospermopsin and related alkaloids via an intramolecular 1,3-dipolar cycloaddition reaction.
  • To synthesize boc-3-(1-methylcyclopropyl)-D-alanine, which is used as an intermediate to prepare 4-fluoroproline-based analogs as potent tripeptide thrombin inhibitors.
  • In the total synthesis of potent hepatotoxic alkaloid 7-epicylindrospermopsin by intramolecular 1,3-dipolar cycloaddition and nitroaldol reaction.
  • To prepare differentially functionalized diaminoglutamic acids via radical reaction of selenide with methyl 2-acetamidoacrylate.

Synthesis

Tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate could be synthesize via a three-step procedure from erythro-2-amino-1,2-diphenylethanol

tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Suppliers

China 88 Germany 2 India 3 Switzerland 1 United Kingdom 3 United States 17 Global 114
Guangzhou Qianguang Trade Co., Ltd.
Tel
020-39071117 18030085485
Fax
020-39071119
Email
2797782741@qq.com
Country
China
ProdList
291
Advantage
55
Tianjin Derchemist Science & Technology Co., Ltd.
Tel
22-58627059 13920586291
Fax
022-58620305
Email
zdcomcon@126.com
Country
China
ProdList
3461
Advantage
50
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
ForeChem (Nantong) Technology Co.,Ltd.
Tel
513-85982855 18921614129
Fax
051385915507
Email
sales@xianxingpharm.com
Country
China
ProdList
2011
Advantage
61
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9511
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9810
Advantage
59
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
6791
Advantage
65
Shanghai Aobo pharmaceutical Technology Co., Ltd
Tel
86-21-51320499
Fax
86-21-51320368
Email
aobo@aobopharm.com
Country
China
ProdList
297
Advantage
57
China Langchem Inc.
Tel
021-58956006 15800617331
Fax
021-58956100
Email
sales4@langchem.com
Country
China
ProdList
208
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Suzhou Sibian Chemical Technology Co.,Ltd.
Tel
0512-65617459 18915409046
Fax
0512-65617459
Email
sales@sibian-chem.com
Country
China
ProdList
1922
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9478
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Shanghai potentpharm CO.,Ltd
Tel
(86) 21 51969655
Fax
(86) 21 51969655， QQ：33109286， 263541193
Country
China
ProdList
487
Advantage
22
Syncozymes (Shanghai) Co.,Ltd.
Tel
021-68187180-819 13681683526
Fax
021-68187179
Email
lchen@syncozymes.com
Country
China
ProdList
227
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Shijiazhuang Lickon PharmaTech Co., Ltd.
Tel
031185291771 13832391721
Fax
0311-67305698
Email
yaofeng2005@163.com
Country
China
ProdList
980
Advantage
58
Shanghai Balmxy Pharmaceutical Co., Ltd
Tel
021-24206007 13764915196
Fax
86-021-23027023
Email
sales@balmxy.com
Country
China
ProdList
6779
Advantage
55
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10274
Advantage
55
Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5734
Advantage
55
Shanghai Jovan Biochemical Technology Co. Ltd.
Tel
+86-021-61654350
Fax
+86-021-61654350
Email
1245958370@qq.com
Country
China
ProdList
2982
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Bellen Chemistry Co., Ltd.
Tel
010-60400365-8001 15910885229
Fax
010-60400361
Email
service@bellenchem.com
Country
China
ProdList
4508
Advantage
60
3A SpeedChemical Inc
Tel
21-65679720
Fax
0086-21-5186 1128
Email
service@speedchemical.com
Country
China
ProdList
604
Advantage
55
Struchem Co., Ltd.
Tel
0512-0512-63009836 15365350169
Fax
0512-63006936
Email
helen@struchem.com
Country
China
ProdList
3984
Advantage
60
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7979
Advantage
55
Chengdu DingDang Pharmaceutical Co., Ltd.
Tel
028-86040038 13980902949;
Fax
028-85149890
Email
market@dingdangchem.com
Country
China
ProdList
1845
Advantage
55
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Shanghai TuZhi Chemical Co., Ltd.
Tel
19542790274 19542790274
Fax
QQ1456295541
Email
2119559397@qq.com
Country
China
ProdList
881
Advantage
50
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9976
Advantage
55
Greenherbs Science and Technology Development Co., Ltd.
Tel
010-61136123
Fax
+86 (10) 8857-9127
Email
pub02@greenherbs.com.cn
Country
China
ProdList
4049
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
9998
Advantage
58
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Shanghai YuMei Pharmaceutical Chemical Co., Ltd.
Tel
13661490451 13671802554
Fax
QQ627235036
Email
xyfn@163.com
Country
China
ProdList
582
Advantage
58
Wuxi AppTec
Tel
022-59987777 13552403979
Email
jia_guoqiang@wuxiapptec.com
Country
China
ProdList
22345
Advantage
58
Shanghai Leefloor Industrial Co., Ltd.
Tel
021-69156110 13611751650
Fax
021-69156110
Email
leefloor2016@163.com
Country
CHINA
ProdList
296
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718 +86-13336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29793
Advantage
60
Aikon International Limited
Tel
025-66028182 18112977050
Fax
(3)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
15818
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 18016230971
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25004
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6037 18920794737
Email
sales@heowns.com
Country
China
ProdList
23018
Advantage
60
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Cool Pharm, Ltd
Tel
18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
13010
Advantage
58
More
Less

View Lastest Price from tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate 112741-50-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate 112741-50-1
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-03

112741-50-1, tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylateRelated Search:

tert-Butanol Cyhalofop-butyl Buprofezin Tridemorph 2-Butoxyethanol Diethylene glycol monobutyl ether Dimethomorph Moroxydine hydrochloride tert-Butyl peroxyacetate tert-Butyl acetate Biphenyl Butyl acrylate Butyl acetate Moroxydine Phenmetrazine (5R,6S)-5,6-Diphenyl-2-morpholinone 3-methylmorpholine (S)-2-Methyl-morpholine

  • (2S,3R)-6-Oxo-2,3-diphenyl-morpholine-4-carboxylic acid tert-butyl ester
  • (5S,6R)-(+)-4-Boc-5,6-diphenyl-2-Morpholinone, 99%
  • (2S,3R)-(+)-N-Boc-6-oxo-2,3-diphenylMorpholine
  • (5R,6S)-N-Boc-5,6-diphenyl-2-morpholinone
  • tert-butyl (2S,3R)-6-oxo-2,3-diphenylMorpholine-4-carboxylate
  • (2<I>S</I>,3<I>R</I>)-(+)-<I>N</I>-<WBR>Boc-<WBR>6-<WBR>oxo-<WBR>2,3-<WBR>diphenylMorpholine
  • (2S, 3R) - (+) - N- t-butoxycarbonyl-6-oxo-2,3-diphenyl-Morpholine
  • (2S,3R)-tert-Butyl
  • 6-oxo-2,3-diphenylMorpholine-4-carboxylate
  • (2S,3R)-6-Oxo-2,3-diphenyl-4-morpholinecarboxylic Acid 1,1-Dimethylethyl Ester
  • (2S,3R)-6-oxo-2,3-diphenylmorpholine-4-carboxylate
  • (2S,3R)-(+)-N-tert-Butoxycarbonyl-6-oxo-2,3-diphenylmorpholine
  • (2S,3R)-6-Oxo-2,3-diphenyl-4-morpholinecarboxylic Acid tert-Butyl Ester,99%e.e.
  • TERT-BUTYL (2S,3R)-(+)-6-OXO-2,3-DIPHENYL-4-MORPHOLINECARBOXYLATE
  • N-TERT-BUTOXYCARBONYL-(2S,3R)-(+)-6-OXO-2,3-DIPHENYL-4-MORPHOLINE-CARBOXYLATE
  • N-BOC(2S, 3R)-(+)-6-OXO-2,3-DIPHENYL-4-MORPHOLINE CARBOXYLATE
  • (2S,3R)-6-Oxo-2,3-diphenyl-4-morpholinecarboxylic Acid tert-Butyl Ester
  • (5R,6S)-4-TERT-BUTOXYCARBONYL-5,6-DIPHENYLMORPHOLIN-2-ONE
  • tert-butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morph
  • TERT-BUTYL (2S,3R)-(+)-6-OXO-2,3-DIPHENY L-4-MORPHOLINECARBOXYLATE, 99% (99% EE)
  • (2S,3R)-tert-Butyl 6-oxo-2,3- diphenylmorpholine-4-carboxylate
  • (5S,6R)-4-tert-Butoxycarbonyl-5,6-diphenylmorpholin-2-one
  • 4-Morpholinecarboxylic acid, 6-oxo-2,3-diphenyl-, 1,1-dimethylethyl ester, (2S,3R)-
  • 2S,3R-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
  • 4-t-Butoxycarbonyl-5,6-diphenyl-2,3,5,6-tetrahydro-4H-oxazin-2-one
  • 112741-50-1
  • 41-50-1
  • Morpholines
  • Heterocyclic Building Blocks
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Chiral Building Blocks
  • Heterocyclic Building Blocks
  • Morpholines
  • API intermediates