ChemicalBook > CAS DataBase List > Sasapyrine

Sasapyrine

Product Name
Sasapyrine
CAS No.
552-94-3
Chemical Name
Sasapyrine
Synonyms
Salina;diagen;Salysal;Disalyl;Nobacid;Salical;salflex;Saloxium;salgesic;salsitab
CBNumber
CB1240724
Molecular Formula
C14H10O5
Formula Weight
258.23
MOL File
552-94-3.mol
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Sasapyrine Property

Melting point:
139-151 °C
Boiling point:
361.48°C (rough estimate)
Density 
1.3326 (rough estimate)
refractive index 
1.4825 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: ≥15mg/mL
pka
pKa 3.5 (Uncertain);9.8 (Uncertain)
form 
Crystalline Powder
color 
white to tan
Water Solubility 
HYDROLYSIS
Sensitive 
Moisture Sensitive
Merck 
14,8339
CAS DataBase Reference
552-94-3
NIST Chemistry Reference
2-Carboxyphenyl salicylate(552-94-3)
EPA Substance Registry System
Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester (552-94-3)
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Safety

Hazard Codes 
Xi,N,Xn
Risk Statements 
36/37/38-50-22
Safety Statements 
37/39-26-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
DH2080000
TSCA 
Yes
HS Code 
29182300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1941
Product name
Salsalate (Aspirin Impurity E)
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
200mg
Price
$273.6
Updated
2024/03/01
Sigma-Aldrich
Product number
1609807
Product name
Salsalate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
150mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
S0129
Product name
2-Carboxyphenyl Salicylate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
S0129
Product name
2-Carboxyphenyl Salicylate
Purity
>98.0%(HPLC)(T)
Packaging
100g
Price
$61
Updated
2023/06/20
Alfa Aesar
Product number
B22444
Product name
Salicylsalicylic acid, 98%
Packaging
25g
Price
$54.65
Updated
2024/03/01
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Sasapyrine Chemical Properties,Usage,Production

Description

Salsalate, or salicylsalicylic acid, (pKa 3.5 [COOH], 9.8 [AR-OH]) is a dimer of salicylic acid. It is insoluble in gastric juice but is soluble in the small intestine, where it is partially hydrolyzed to two molecules of salicylic acid and absorbed. On a molar basis, it produces 15% less salicylic acid than aspirin. It does not cause GI blood loss and can be given to aspirin-sensitive patients. Salsalate is available as capsules and tablets.

Chemical Properties

white crystalline powder

Uses

Salicylsalicylic acid is used in organic synthesis and functions as a plant hormone, as a key ingredient in topical anti-acne products.

Uses

Nonacetylated (e.g., sodium salicylate) and acetylated (aspirin) forms of salicylate are widely used to target inflammation in the treatment of insulin resistance, type 2 diabetes, or rheumatic pain. Sasapyrine is a dimeric prodrug comprising two esterified salicylate moieties. It is advantageous over sodium salicylate because it is insoluble at the acid pH of the stomach and passes suspended but undissolved into the small intestine, sparing the gastric mucosa direct contact.

Uses

Nonacetylated aspirin analog. Analgesic, anti-inflammatory.

Definition

ChEBI: A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthrit s and also shows activity against type II diabetes.

brand name

Disalcid (3M Pharmaceuticals).

General Description

Salsalate, salicylsalicylic acid (Amigesic, Disalcid,Salflex), is the ester formed between two salicylic acidmolecules. It is rapidly hydrolyzed to salicylic acid followingits absorption. It reportedly causes less gastric irritationthan aspirin, because it is relatively insoluble inthe stomach and is not absorbed until it reaches the smallintestine.

Biochem/physiol Actions

Salsalate is a nonsteroidal anti-inflammatory drug (NSAID), a nonacetylated salicylate with no more problems of gastrointestinal bleeding than placebo. It inhibits synthesis and release of prostaglandins through the inactivation of cyclooxygenase-1 (COX-1) and COX-2. Salsalate is currently being investigated as a treatment for Type 2 diabetes with possible use to prevent the disease in people at risk. It reduces blood glucose concentrations in patients with type 2 diabetes, as well as in insulin-resistant patients without diabetes.

Sasapyrine Preparation Products And Raw materials

Raw materials

Preparation Products

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Sasapyrine Suppliers

Belgium 3 Canada 3 China 188 Europe 2 France 1 Germany 7 India 39 Japan 4 Jordan 1 Poland 1 Switzerland 1 The Netherlands 1 United Kingdom 14 United States 52 USA 1 Global 318
Ark Pharm, Inc.
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View Lastest Price from Sasapyrine manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Sasapyrine 552-94-3
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-20
Hebei Yanxi Chemical Co., Ltd.
Product
Sasapyrine 552-94-3
Price
US $100.00/kgkg
Min. Order
1kgkg
Purity
0.99
Supply Ability
100
Release date
2023-09-14
Hebei Weibang Biotechnology Co., Ltd
Product
Sasapyrine 552-94-3
Price
US $0.00-0.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25

552-94-3, SasapyrineRelated Search:

Sodium salicylate Isoamyl o-hydroxybenzoate 4-Hydroxybenzoic acid Phenyl salicylate Alginic Sodium Diester 3-Hydroxybenzoic acid 2'-Hydroxy-3-phenylpropiophenone Citric acid Folic acid Methyl acrylate Salicylic acid Hyaluronic acid Ethyl 2-(Chlorosulfonyl)acetate BUTYL OLEATE Acetylsalicylic acid ACETYLSALICYLSALICYLIC ACID Butylparaben Bifendate

  • salicylicacid,bimolecularester
  • Salicyloxysalicylic acid
  • Salicyloylsalicylic acid
  • salicyloylsalicylicacid
  • Salicyl-salicylate
  • Salina
  • Saloxium
  • Salysal
  • Sasapirin
  • Sasapyrin
  • Sasapyrinum
  • disalicylicacid
  • Disalyl
  • Nobacid
  • NSC-49171
  • Sal Ester Sal
  • Salical
  • Salicylic acid, bimolecular ester
  • Salicylic acid, bimol. ester
  • Salicylic acid 2-carboxyphenyl
  • Salicylsalicylic acid,99%
  • Salsalate (150 mg)
  • Salsalate (125 mg)
  • Double salicylate
  • 2-Salicyloyloxybenzoic Acid O-Salicyloylsalicylic Acid Salicylic Acid 2-Carboxyphenyl Ester Salsalate
  • Aspirin EP IMpurity E
  • Aspirin IMpurity E
  • 2-[(2-hydroxyphenyl)carbonyloxy]benzoic acid
  • Acetylsalicylic Acid IMpurity E (Aspirin IMpurity E)
  • Sasapyrine Solution, 100ppm
  • Acetylsalicylic Acid EP Impurity E
  • Acetylsalicylic Acid Impurity 5（Acetylsalicylic Acid EP Impurity E）
  • O-SALICYLOYLSALICYLIC ACID
  • O-SALICYLSALICYLIC ACID
  • mono-gesic
  • salflex
  • salgesic
  • SALICYLSALICYLIC ACID
  • SALICYLIC ACID SALICYLATE
  • salicylylsalicylic acid
  • TIMTEC-BB SBB003097
  • SASAPYRINE
  • salsitab
  • SALSALATE
  • Arcylate
  • SALSALATE USP XXIV
  • SALICYLSALICYLIC ACID 99%
  • Salicylsalicylicacid,98%
  • disalcid
  • DISALICYLIC ACID, SALSALATE
  • diagen
  • 2-HYDROXYBENZOIC ACID 2-CARBOXYPHENYL ESTER
  • 2-CARBOXYPHENYL SALICYLATE
  • 2-SALICYLOYLOXYBENZOIC ACID
  • 2-salicylsalicylic acid
  • amigesic
  • 2-[(2-Hydroxybenzoyl)oxy]benzoic acid
  • 2-hydroxy-benzoicaci2-carboxyphenylester