ELASTATINAL

Product Name: ELASTATINAL
CAS No.: 51798-45-9
Chemical Name: ELASTATINAL
Synonyms: ELASTATINAL;AIDS-006470;Leu-co-cpd-Gln-Ala-h;ELASTATINAL USP/EP/BP;elastatinal from microbial source;N-[-N-ALPHA-CARBONYL-CPD-GLN-ALA-AL]-LEU;l-glutamamide,l-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-n-(((1-carboxy-3-m;N-[(S)-1-CARBOXYISOPENTYL]CARBAMOYL-ALPHA-[2-IMINOHEXAHYDRO-4(S)-PYRIMIDYL-(S)-GLYCYL-(S)-GLUTAMINYL-(S)-ALANINAL];Nα-[2-(2-Amino-1,4,5,6-tetrahydropyrimidin-4-yl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]-L-glycyl]-N1-(1-methyl-2-oxoethyl)-L-glutaminamide;L-Glutamamide, (2S)-2-(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-N-(1S)-1-carboxy-3-methylbutylaminocarbonylglycyl-N1-(1S)-1-methyl-2-oxoethyl-
CBNumber: CB1249000
Molecular Formula: C21H36N8O7
Formula Weight: 512.56
MOL File: 51798-45-9.mol

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ELASTATINAL Property

storage temp.: -20°C
solubility: H₂O: 20 mg/mL, clear, yellow
form: Yellow solid.
color: off-white
BRN: 873543
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: LZ9600000
F: 10

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E0881
Product name: Elastatinal
Purity: microbial
Packaging: 5mg
Price: $181
Updated: 2024/03/01

Sigma-Aldrich

Product number: E0881
Product name: Elastatinal
Purity: microbial
Packaging: 10mg
Price: $330
Updated: 2024/03/01

Alfa Aesar

Product number: J61120
Product name: Elastatinal
Packaging: 5mg
Price: $147
Updated: 2023/06/20

Alfa Aesar

Product number: J61120
Product name: Elastatinal
Packaging: 25mg
Price: $432
Updated: 2021/12/16

Cayman Chemical

Product number: 22288
Product name: Elastatinal
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

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ELASTATINAL Chemical Properties,Usage,Production

Description

Elastatinal is a potent inhibitor of pancreatic elastase (K_i = 240 nM) that is produced by various species of Actinomycetes. It more strongly inhibits pancreatic elastase versus the leukocyte-derived enzyme. Elastatinal reduces electrophoretic mobilities of 2A proteinases from poliovirus and human rhinovirus 14 in a dose-dependent manner, indicating substrate recognition by 2A proteinases is similar to that of pancreatic elastases. It can also inhibit elastase-like protease collagenolytic protease from C. maenas digestive glands.

Uses

Elastatinal is an elastase inhibitor.

Biochem/physiol Actions

Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes.

References

1) Umezawa et al. (1973), Letter: Elastatinal, a new elastase inhibitor produced by actinomycetes; J. Antibiotics, 26 787 2) Nakajima et al. (1992), Identification of elastase as a secretory protease from cultured rat microglia; J. Neurochem., 58 1401 3) Molla et al. (1993), Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteases by elastase-specific inhibitors; J. Virol., 67 4688 4) Menendez-Arias et al. (1992), Isolation and characterization of alpha 2-macroglobulin-protease complexes from purified mouse mammary tumor virus and culture supernatants from virus-infected cell lines; J. Biol. Chem., 267 11392

ELASTATINAL Preparation Products And Raw materials

Raw materials

Preparation Products

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ELASTATINAL Suppliers

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View Lastest Price from ELASTATINAL manufacturers

Career Henan Chemical Co

Product: ELASTATINAL 51798-45-9
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2020-01-08

51798-45-9, ELASTATINALRelated Search:

ACTINONIN P-5091 6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine ZPCK Elastatinal (1.24822) ELASTATINAL Dibutylurea

N-[-N-ALPHA-CARBONYL-CPD-GLN-ALA-AL]-LEU

elastatinal from microbial source

L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamide, stereoisomer

Leu-co-cpd-Gln-Ala-h

L-Glutamamide, (2S)-2-(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-N-(1S)-1-carboxy-3-methylbutylaminocarbonylglycyl-N1-(1S)-1-methyl-2-oxoethyl-

(2s)-2-[(4s)-2-amino-1,4,5,6-tetrahydro4-pyrimidinyl]-n-[[[(1s)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-n1-[(1s)-1-methyl-2-oxoethyl-l-glutamamide

AIDS-006470

Nα-[2-(2-Amino-1,4,5,6-tetrahydropyrimidin-4-yl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]-L-glycyl]-N1-(1-methyl-2-oxoethyl)-L-glutaminamide

(2S)-2-[(4S)-2-Amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-L-glutamamide

l-glutamamide,l-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-n-(((1-carboxy-3-m

ELASTATINAL

N-[(S)-1-CARBOXYISOPENTYL]CARBAMOYL-ALPHA-[2-IMINOHEXAHYDRO-4(S)-PYRIMIDYL-(S)-GLYCYL-(S)-GLUTAMINYL-(S)-ALANINAL]

L-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-

ELASTATINAL USP/EP/BP

(2S)-2-[[(1S)-2-[[(2S)-5-amino-1,5-dioxo-1-[[(2S)-1-oxopropan-2-yl]amino]pentan-2-yl]amino]-1-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-oxoethyl]carbamoylamino]-4-methylpentanoic acid

51798-45-9

C21H36N8O7

C21H36N8O6

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