2-Chloro-4,5-difluorobenzoic acid
Uses- Product Name
- 2-Chloro-4,5-difluorobenzoic acid
- CAS No.
- 110877-64-0
- Chemical Name
- 2-Chloro-4,5-difluorobenzoic acid
- Synonyms
- oro-4,5-difL;CAS:110877-64-0;TIMTEC-BB SBB003616;RARECHEM AL BO 1000;2-chloro-4,5-difluorophenyl acid;2-CHLORO-4,5-DIFLUOROBENZOIC ACID;Benzoicacid, 2-chloro-4,5-difluoro-;2-Chloro-4,5-difluorobenzoic acid 99%;2-CHLORO-4,5-DIFLUOROBENZOIC ACID,98%;2-Chloro-4,5-difluorobenzoic Acid >
- CBNumber
- CB1251209
- Molecular Formula
- C7H3ClF2O2
- Formula Weight
- 192.55
- MOL File
- 110877-64-0.mol
2-Chloro-4,5-difluorobenzoic acid Property
- Melting point:
- 103-106 °C (lit.)
- Boiling point:
- 258 °C
- Density
- 1.4821 (estimate)
- Flash point:
- 257-259°C
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.50±0.25(Predicted)
- form
- Fine Crystalline Powder
- color
- White
- Water Solubility
- 5.0 g/L (20 ºC)
- BRN
- 4247522
- InChI
- InChI=1S/C7H3ClF2O2/c8-4-2-6(10)5(9)1-3(4)7(11)12/h1-2H,(H,11,12)
- InChIKey
- CGFMLBSNHNWJAW-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(F)=C(F)C=C1Cl
- CAS DataBase Reference
- 110877-64-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-41-43-21/22-20/21/22
- Safety Statements
- 26-39-36/37/39-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 405388
- Product name
- 2-Chloro-4,5-difluorobenzoic acid
- Purity
- 99%
- Packaging
- 5g
- Price
- $32.1
- Updated
- 2023/06/20
- Product number
- C1460
- Product name
- 2-Chloro-4,5-difluorobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $44
- Updated
- 2025/07/31
- Product number
- C1460
- Product name
- 2-Chloro-4,5-difluorobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 250g
- Price
- $264
- Updated
- 2025/07/31
- Product number
- C1460
- Product name
- 2-Chloro-4,5-difluorobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- C585323
- Product name
- 2-Chloro-4,5-difluorobenzoic Acid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
2-Chloro-4,5-difluorobenzoic acid Chemical Properties,Usage,Production
Uses
2-Chloro-4,5-difluorobenzoic acid (CDFBA) is an important pharmaceutical and pesticide intermediate, mainly used in the production of novel antibacterial drugs such as fluopyridine and cardiovascular drugs.
Chemical Properties
white to light yellow crystal powder
General Description
2-Chloro-4,5-difluorobenzoic acid is an important intermediate in medicinal compounds and pesticides. Lanthanide complexes with the 2-chloro-4,5-difluorobenzoate (2-cl-4,5-dfba) and 1,10-phenanthroline (phen), have been prepared and their crystal structures have been studied. Efficient synthesis of 2-chloro-4,5-difluorobenzoic acid v-difluororbenzene has been reported.
Synthesis
121872-94-4
110877-64-0
Example 2 Preparation of 2-chloro-4,5-difluorobenzoic acid: 280.4 g (0.4 mol) of 12% sodium hypochlorite aqueous solution was added to 19.1 g (0.1 mol) of 1-(2-chloro-4,5-difluorophenyl)ethanone. The reaction mixture was stirred under reflux conditions for 4 hours. After completion of the reaction, the reaction was cooled to room temperature and the pH was adjusted slowly and dropwise with concentrated hydrochloric acid to 1. The precipitated white crystals were dissolved with dichloromethane and the organic and aqueous phases were separated. The aqueous phase was extracted twice with dichloromethane and the organic phases were combined. The solvent was removed by distillation to give 16.4 g (yield: 85.1%) of 2-chloro-4,5-difluorobenzoic acid as white crystals.
References
[1] Organic Preparations and Procedures International, 1991, vol. 23, # 5, p. 655 - 658
[2] Patent: US4994610, 1991, A
[3] Patent: US5093515, 1992, A
[4] Organic Preparations and Procedures International, 1996, vol. 28, # 2, p. 245 - 246
[5] Patent: EP342849, 1990, A3
2-Chloro-4,5-difluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-4,5-difluorobenzoic acid manufacturers
- Product
- 2-Chloro-4,5-difluorobenzoic acid 110877-64-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-09
- Product
- 2-Chloro-4,5-difluorobenzoic acid 110877-64-0
- Price
- US $250.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 300MT/year
- Release date
- 2019-12-24
- Product
- 2-Chloro-4,5-difluorobenzoic acid 110877-64-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11