ChemicalBook > CAS DataBase List > 2-Chloro-4,5-difluorobenzoic acid

2-Chloro-4,5-difluorobenzoic acid

Uses

Product Name: 2-Chloro-4,5-difluorobenzoic acid
CAS No.: 110877-64-0
Chemical Name: 2-Chloro-4,5-difluorobenzoic acid
Synonyms: oro-4,5-difL;CAS:110877-64-0;TIMTEC-BB SBB003616;RARECHEM AL BO 1000;2-chloro-4,5-difluorophenyl acid;2-CHLORO-4,5-DIFLUOROBENZOIC ACID;Benzoicacid, 2-chloro-4,5-difluoro-;2-Chloro-4,5-difluorobenzoic acid 99%;2-CHLORO-4,5-DIFLUOROBENZOIC ACID,98%;2-Chloro-4,5-difluorobenzoic Acid >
CBNumber: CB1251209
Molecular Formula: C7H3ClF2O2
Formula Weight: 192.55
MOL File: 110877-64-0.mol

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2-Chloro-4,5-difluorobenzoic acid Property

Melting point:: 103-106 °C (lit.)
Boiling point:: 258 °C
Density: 1.4821 (estimate)
Flash point:: 257-259°C
storage temp.: Sealed in dry,Room Temperature
pka: 2.50±0.25(Predicted)
form: Fine Crystalline Powder
color: White
Water Solubility: 5.0 g/L (20 ºC)
BRN: 4247522
InChI: InChI=1S/C7H3ClF2O2/c8-4-2-6(10)5(9)1-3(4)7(11)12/h1-2H,(H,11,12)
InChIKey: CGFMLBSNHNWJAW-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(F)=C(F)C=C1Cl
CAS DataBase Reference: 110877-64-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-43-21/22-20/21/22
Safety Statements: 26-39-36/37/39-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 405388
Product name: 2-Chloro-4,5-difluorobenzoic acid
Purity: 99%
Packaging: 5g
Price: $32.1
Updated: 2023/06/20

TCI Chemical

Product number: C1460
Product name: 2-Chloro-4,5-difluorobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $44
Updated: 2025/07/31

TCI Chemical

Product number: C1460
Product name: 2-Chloro-4,5-difluorobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 250g
Price: $264
Updated: 2025/07/31

TCI Chemical

Product number: C1460
Product name: 2-Chloro-4,5-difluorobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $16
Updated: 2025/07/31

TRC

Product number: C585323
Product name: 2-Chloro-4,5-difluorobenzoic Acid
Packaging: 10mg
Price: $45
Updated: 2021/12/16

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2-Chloro-4,5-difluorobenzoic acid Chemical Properties,Usage,Production

Uses

2-Chloro-4,5-difluorobenzoic acid (CDFBA) is an important pharmaceutical and pesticide intermediate, mainly used in the production of novel antibacterial drugs such as fluopyridine and cardiovascular drugs.

Chemical Properties

white to light yellow crystal powder

General Description

2-Chloro-4,5-difluorobenzoic acid is an important intermediate in medicinal compounds and pesticides. Lanthanide complexes with the 2-chloro-4,5-difluorobenzoate (2-cl-4,5-dfba) and 1,10-phenanthroline (phen), have been prepared and their crystal structures have been studied. Efficient synthesis of 2-chloro-4,5-difluorobenzoic acid v-difluororbenzene has been reported.

Synthesis

121872-94-4

110877-64-0

Example 2 Preparation of 2-chloro-4,5-difluorobenzoic acid: 280.4 g (0.4 mol) of 12% sodium hypochlorite aqueous solution was added to 19.1 g (0.1 mol) of 1-(2-chloro-4,5-difluorophenyl)ethanone. The reaction mixture was stirred under reflux conditions for 4 hours. After completion of the reaction, the reaction was cooled to room temperature and the pH was adjusted slowly and dropwise with concentrated hydrochloric acid to 1. The precipitated white crystals were dissolved with dichloromethane and the organic and aqueous phases were separated. The aqueous phase was extracted twice with dichloromethane and the organic phases were combined. The solvent was removed by distillation to give 16.4 g (yield: 85.1%) of 2-chloro-4,5-difluorobenzoic acid as white crystals.

References

[1] Organic Preparations and Procedures International, 1991, vol. 23, # 5, p. 655 - 658
[2] Patent: US4994610, 1991, A
[3] Patent: US5093515, 1992, A
[4] Organic Preparations and Procedures International, 1996, vol. 28, # 2, p. 245 - 246
[5] Patent: EP342849, 1990, A3

2-Chloro-4,5-difluorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid

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2-Chloro-4,5-difluorobenzoic acid Suppliers

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View Lastest Price from 2-Chloro-4,5-difluorobenzoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Chloro-4,5-difluorobenzoic acid 110877-64-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-09

Speranza Chemical Co., Ltd.

Product: 2-Chloro-4,5-difluorobenzoic acid 110877-64-0
Price: US $250.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 300MT/year
Release date: 2019-12-24

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Chloro-4,5-difluorobenzoic acid 110877-64-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

110877-64-0, 2-Chloro-4,5-difluorobenzoic acidRelated Search:

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CAS:110877-64-0

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Carboxylic Acids

Carbonyl Compounds

Building Blocks

Organic Building Blocks

Fluorine series

Benzoic acid

Carbonyl Compounds

Carboxylic Acids

Aromatic compound

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts