ChemicalBook > CAS DataBase List > 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole
5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole
- Product Name
- 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole
- CAS No.
- 102625-64-9
- Chemical Name
- 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole
- Synonyms
- Pantoprazole-2;PANTOPRAZOLE SULFIDE;pantoprazole sulphide;Pantoprazole Ep Imp B;Pantoprazole Thioether;PantoprazoleSulfide>5-DifluoroMethoxy-2-[(3;Pantoprazole condensate;Pantoprazole Sulfur ether;Pantoprazole EP IMpurity B
- CBNumber
- CB1253016
- Molecular Formula
- C16H15F2N3O3S
- Formula Weight
- 367.37
- MOL File
- 102625-64-9.mol
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5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Property
- Melting point:
- 110-118°C
- Boiling point:
- 526.3±60.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 8.97±0.10(Predicted)
- color
- Off-White to Light Brown
- BRN
- 5358607
- InChI
- InChI=1S/C16H15F2N3O3S/c1-22-13-5-6-19-12(14(13)23-2)8-25-16-20-10-4-3-9(24-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)
- InChIKey
- UKILEIRWOYBGEJ-UHFFFAOYSA-N
- SMILES
- C1(SCC2=NC=CC(OC)=C2OC)NC2=CC(OC(F)F)=CC=C2N=1
- CAS DataBase Reference
- 102625-64-9(CAS DataBase Reference)
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Safety
- HS Code
- 2933399090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- PHR3074
- Product name
- Pantoprazole Related Compound B
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 50MG
- Price
- $336.3
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 1494910
- Product name
- Pantoprazole Related Compound B
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 25mg
- Price
- $1300
- Updated
- 2025/07/31
TCI Chemical
- Product number
- P2066
- Product name
- Pantoprazole Sulfide
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $27
- Updated
- 2025/07/31
TCI Chemical
- Product number
- P2066
- Product name
- Pantoprazole Sulfide
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $81
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 22251
- Product name
- Pantoprazole Sulfide
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
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5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Chemical Properties,Usage,Production
Chemical Properties
Beige Solid
Uses
A metabolite of Pantoprazole, an antiulcerative, gastric pump inhibitor
Uses
Pantoprazole Sulfide (Pantoprazole EP Impurity B) is a metabolite of Pantoprazole (P183000), an antiulcerative, gastric pump inhibitor.
Synthesis
169905-10-6
97963-62-7
102625-64-9
[Example 1] Preparation of 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole: 920 mL of isopropanol, 92.1 g of 5-difluoromethoxy-2-mercapto-1H-benzimidazole, and 95.8 g of 2-chloromethyl-3,4-dimethoxypyridine were added to the reactor. Sodium hydroxide solution (prepared by dissolving 20.5 g of sodium hydroxide in 920 mL of pure water) was added slowly and dropwise to the above mixture, followed by stirring the reaction mixture for 2 hours at room temperature. Upon completion of the reaction, 920 mL of pure water was added to the mixture and stirring was continued for 1 hour. The resulting solid product was collected by filtration and dried under vacuum to give 137.4 g of the target compound in 87.8% yield with a melting point of 94 °C.
References
[1] Patent: WO2009/75516, 2009, A2. Location in patent: Page/Page column 4
[2] Organic Process Research and Development, 2013, vol. 17, # 10, p. 1272 - 1276
5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
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5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Suppliers
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3572
- Advantage
- 66
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
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View Lastest Price from 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole manufacturers
Qiuxian Baitai New Material Co., LTD
- Product
- Pantoprazole sulfide 102625-64-9
- Price
- US $35.00/KG
- Min. Order
- 500KG
- Purity
- ≥98%
- Supply Ability
- 100tons
- Release date
- 2021-11-22
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Pantoprazole Sulfide 102625-64-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Pantoprazole Sulfide 102625-64-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08
102625-64-9, 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazoleRelated Search:
4-Methoxybenzyl alcohol
4-Methoxybenzyl cyanide
p-Anisaldehyde
Tribenuron methyl
p-Anisidine
4-Methoxybenzoic acid
METSULFURON METHYL
4-Methoxyphenol
Anisole
PANTOPRAZOLE SULPHONE SODIUM SALT
Methyl acetate
(Trifluoromethoxy)benzene
Kresoxim-methyl
Guaiacol
Methyl salicylate
Dimethoxymethane
Thiophanate-methyl
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole