JZL 184

ChemicalBook > CAS DataBase List > JZL 184

Product Name: JZL 184
CAS No.: 1101854-58-3
Chemical Name: JZL 184
Synonyms: CS-815;CS-1861;JZL 184;JZL-184; JZL 184;JZL 184 JZL184 JZL-184;JZL184 (with 15% inorganics);MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem;4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)Methyl]-1-piperidinecarboxylate;4-nitrophenyl 4-[bis(2H-1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate;4-Nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate
CBNumber: CB12535677
Molecular Formula: C27H24N2O9
Formula Weight: 520.49
MOL File: 1101854-58-3.mol

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JZL 184 Property

Melting point:: 116-120°C
Boiling point:: 706.4±60.0 °C(Predicted)
Density: 1.467±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 25 mg/ml).
form: White to off-white solid
pka: 13.32±0.29(Predicted)
color: light yellow to yellow-green
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
CAS DataBase Reference: 1101854-58-3

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Safety

RIDADR: UN 2811 6.1 / PGIII
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 475741
Product name: MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem<br />The MAGL Inhibitor III, JZL184, also referenced under CAS 1101854-58-3, controls the biological activity of MAGL.
Packaging: 10mg
Price: $159
Updated: 2024/03/01

Sigma-Aldrich

Product number: J3455
Product name: JZL 184 hydrate
Purity: ≥97% (HPLC)
Packaging: 5MG
Price: $170
Updated: 2023/06/20

Cayman Chemical

Product number: 13158
Product name: JZL 184
Purity: ≥97%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 13158
Product name: JZL 184
Purity: ≥97%
Packaging: 10mg
Price: $74
Updated: 2024/03/01

Cayman Chemical

Product number: 13158
Product name: JZL 184
Purity: ≥97%
Packaging: 50mg
Price: $299
Updated: 2024/03/01

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JZL 184 Chemical Properties,Usage,Production

Description

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC₅₀ values of 8 nM and 4 μM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively. When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB₁) agonists.

Uses

JZL 184 hydrate has been used as an inhibitor of monoacylglycerol lipase to study its effect on human osteoblast differentiation and proliferation and postsynaptic neurons.

Uses

JZL184 is a strong and selective inhibitor of Monoglyceride Lipase.

Definition

ChEBI: 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]-1-piperidinecarboxylic acid (4-nitrophenyl) ester is a member of benzodioxoles.

Biochem/physiol Actions

JZL184 selectively inhibits MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Anandamide and 2-AG are the two endogenous endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Anandamide is predominantly metabolized by fatty acid amide hydrolase (FAAH), whereas monoacylglycerol lipase (MAGL) is thought to be the enzyme primarily responsible for the degradation of 2-AG. It is difficult to separate the activities of the two because most currently available inhibitors of MAGL are not selective, and also inhibit FAAH or other enzymes. JZL 184 is the first selective inhibitor of MAGL with nanomolar portency and over 200-fold selectivity for MAGL vs FAAH. When administered to mice, JZL184 increased levels of 2-arachidonoylglycerol in the brain by about 8-fold, with no effect on levels of anandamide.

storage

Store at -20°C

References

1) Long et al. (2009), Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects; Nat. Chem. Biol.,5 37 2) Pan et al. (2009), Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxyl)methyl)piperidine-1-carboxylate (JZL 184) enhances retrograde endocannabinoid signaling; J. Pharmacol. Exp. Ther., 331 591 3) Kinsey et al. (2009), Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain; J. Pharmacol. Exp. Ther., 330 902

JZL 184 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from JZL 184 manufacturers

Career Henan Chemical Co

Product: JZL 184 1101854-58-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-23

1101854-58-3, JZL 184Related Search:

(E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Fatostatin A N-(1-OXO-4Z,7Z,10Z,13Z,16Z,19Z-DOCOSAHEXAENYL)-GLYCINE PF-622 N-Arachidonyl maleimide Bortezomib Tiotropium bromide hydrate URB597 OTX015 PD 0332991 HCl BEZ235 (NVP-BEZ235, Dactolisib)

JZL 184 JZL184 JZL-184

JZL 184

4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)Methyl]-1-piperidinecarboxylate

4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester

1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester

4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester JZL 184

MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem

JZL-184; JZL 184

CS-815

CS-1861

JZL 184 ?JZL184 ?JZL-184 ?(4-Nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate

1-Piperidinecarboxylicacid,4-Chemicalbook[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-,4-nitrophenylester

JZL184 (with 15% inorganics)

4-Nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate

4-nitrophenyl 4-[bis(2H-1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate

1101854-58-3

Inhibitors