ChemicalBook > CAS DataBase List > RETRORSINE

RETRORSINE

Product Name
RETRORSINE
CAS No.
480-54-6
Chemical Name
RETRORSINE
Synonyms
Retrosine;RETRORSIN;RETRORSINE;Retrorcine;β-Longilobine;RETRORSINE(AS);BETA-LONGILOBINE;cis-retronecicacidesterofretronecine;16-dione,12,18-dihydroxy-senecionan-1;12,18-DIHYDROXYSENECIONAN-11,16-DIONE
CBNumber
CB1256406
Molecular Formula
C18H25NO6
Formula Weight
351.39
MOL File
480-54-6.mol
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RETRORSINE Property

Melting point:
208-211 °C (lit.)
alpha 
D18 -17.6° (c = 1.99 in ethanol)
Boiling point:
485.2°C (rough estimate)
Density 
1.32±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5100 (estimate)
storage temp. 
2-8°C
pka
12.00±0.40(Predicted)
form 
Solid
color 
White to off-white
Merck 
13,8253
InChIKey
BCJMNZRQJAVDLD-VMOBWIEOSA-N
CAS DataBase Reference
480-54-6
IARC
3 (Vol. 10, Sup 7) 1987
EPA Substance Registry System
Retrorsine (480-54-6)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
22-36/37/39-45
RIDADR 
1544
WGK Germany 
3
RTECS 
VH7525000
HazardClass 
6.1(a)
PackingGroup 
II
Hazardous Substances Data
480-54-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R0382
Product name
Retrorsine
Purity
≥90% (HPLC)
Packaging
100mg
Price
$261
Updated
2024/03/01
Sigma-Aldrich
Product number
R0382
Product name
Retrorsine
Purity
≥90% (HPLC)
Packaging
500mg
Price
$898
Updated
2024/03/01
Sigma-Aldrich
Product number
PHL89775
Product name
Retrorsine
Purity
phyproof Reference Substance
Packaging
10mg
Price
$342
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
API0009902
Product name
RETRORSINE
Purity
95.00%
Packaging
10MG
Price
$573.3
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48570
Product name
Retrorsine
Packaging
10mg
Price
$585
Updated
2021/12/16
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RETRORSINE Chemical Properties,Usage,Production

Uses

Retrorsine-D4 is a labelled analogue of Retrorsine (R279000). Retrorsine is a pyrrolizidine alkaloid that blocks the hepatocyte cell cycle, ultimately affecting hepatocyte proliferative capacity.

Definition

ChEBI: Retrorsine is a macrolide.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. hhtation data reported. When heated to decomposition it emits toxic fumes of NOx.

RETRORSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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480-54-6, RETRORSINERelated Search:

ALLYL ISOVALERATE 3-METHOXYPYRROLIDINE (2-Propenyloxy)propanol Butyl hydroxyacetate 3-ALLYLOXY-1,2-PROPANEDIOL 2-Dimethylaminoethyl acetate DIMETHYL 2-METHYLADIPATE 3-Butoxypropanamine 2-HYDROXY-3-METHYLBUTYRIC ACID 3-Pyrrolidinol 2-HYDROXY-N-BUTYRIC ACID ETHYL ESTER RETRORSINE Methyl (R)-(+)-lactate ISO-PROPYL ACRYLATE ISOBUTYRIC ACID N-PROPYL ESTER 3-(DIMETHYLAMINO)PROPYL ACRYLATE 1-AMINO-5-HEXENE 2-METHYL-5-HEXEN-2-OL

  • BETA-LONGILOBINE
  • 12,18-DIHYDROXYSENECIONAN-11,16-DIONE
  • RETRORSIN
  • RETRORSINE
  • 16-dione,12,18-dihydroxy-senecionan-1
  • 5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-hydroxymethyl-5-3-ethylidene-4
  • cis-retronecicacidesterofretronecine
  • methyl(1,6)dioxacyclododeca(2,3,4-gh)pyrrolizidine-2,7-dione
  • Retrosine
  • trans-15-ethylidene-12beta-hydroxy-12alpha-hydroxymethyl-13beta-methylsenec-1-
  • RETRORSINE(AS)
  • β-Longilobine, 12,18-Dihydroxysenecionan-11,16-dione
  • β-Longilobine
  • Retrorcine
  • [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methyl-, (3Z,5R,6S,14aR,14bR)-
  • 480-54-6
  • C18H23O5N