RETRORSINE Property

Melting point:

208-211 °C (lit.)

alpha 

D18 -17.6° (c = 1.99 in ethanol)

Boiling point:

485.2°C (rough estimate)

Density 

1.32±0.1 g/cm3 (20 ºC 760 Torr)

refractive index 

1.5100 (estimate)

storage temp. 

2-8°C

pka

12.00±0.40(Predicted)

form 

Solid

color 

White to off-white

Merck 

13,8253

InChIKey

BCJMNZRQJAVDLD-VMOBWIEOSA-N

CAS DataBase Reference

480-54-6

IARC

3 (Vol. 10, Sup 7) 1987

EPA Substance Registry System

Retrorsine (480-54-6)

Safety

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

22-36/37/39-45

RIDADR 

1544

WGK Germany 

3

RTECS 

VH7525000

HazardClass 

6.1(a)

PackingGroup 

II

Hazardous Substances Data

480-54-6(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

RETRORSINE Chemical Properties,Usage,Production

Uses

Retrorsine-D4 is a labelled analogue of Retrorsine (R279000). Retrorsine is a pyrrolizidine alkaloid that blocks the hepatocyte cell cycle, ultimately affecting hepatocyte proliferative capacity.

Definition

ChEBI: Retrorsine is a macrolide.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. hhtation data reported. When heated to decomposition it emits toxic fumes of NOx.