Ethambutol dihydrochloride

Product Name: Ethambutol dihydrochloride
CAS No.: 1070-11-7
Chemical Name: Ethambutol dihydrochloride
Synonyms: Etibi;Sural;Ebutol;Etapiam;cl40881;Esanbutol;Myambutol;Mycobutol;dadibutol;Dexambutol
CBNumber: CB1256512
Molecular Formula: C10H24N2O2.2ClH
Formula Weight: 277.23
MOL File: 1070-11-7.mol

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Ethambutol dihydrochloride Property

Melting point:: 198-200°C
alpha: D25 +7.6° (c = 2 in water)
storage temp.: 2-8°C
solubility: H2O: soluble50mg/mL
form: powder
color: white
optical activity: [α]25/D 6.0 to 6.7°, c = 10 in water
Water Solubility: Slightly soluble in water
Merck: 14,3720
BCS Class: 3
CAS DataBase Reference: 1070-11-7(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi
Risk Statements: 61-36/37/38
Safety Statements: 53-22-36/37/39-45-36/37-26
WGK Germany: 3
RTECS: EL3854000
HazardClass: IRRITANT
HS Code: 29419000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E4630
Product name: Ethambutol dihydrochloride
Purity: antimycobacterial
Packaging: 25g
Price: $187
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1257007
Product name: Ethambutol hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $261.6
Updated: 2024/03/01

TCI Chemical

Product number: E1011
Product name: (S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride
Purity: >98.0%(T)
Packaging: 5g
Price: $43
Updated: 2024/03/01

TCI Chemical

Product number: E1011
Product name: (S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride
Purity: >98.0%(T)
Packaging: 25g
Price: $133
Updated: 2024/03/01

Alfa Aesar

Product number: J60695
Product name: Ethambutol dihydrochloride
Packaging: 5g
Price: $45.8
Updated: 2024/03/01

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Ethambutol dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Powder

Originator

Myambutol,Lederle,US,1967

Uses

Antibacterial (tuberculostatic)

Uses

Antituberculous

Uses

Ethambutol dihydrochloride it acts as a tuberculostatic antibacterial agent. It is used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate.

Definition

ChEBI: The dihydrchloride salt of ethambutol. A bacteriostatic antimycobacterial drug, it is effective against Mycobacterium tuberculosis and some other mycobacteria. It is used in combination with other antituberculous drugs in the treatment of pulm nary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol dihydrochloride is used alone.

Manufacturing Process

To 27 grams (2.55 mols) of 2-amino-1-butanol was added 100 grams (1.0 mol) of ethylene dichloride. The mixture was heated at reflux and in a few minutes, the exothermic reaction required the removal of exterior heating. After 10 minutes, exterior heating was recommenced for an additional 20 minutes. The hot mixture was then treated with 300 ml of methanol and then cautiously with 84 grams (2.1 mols) of sodium hydroxide in 80 ml of water.
The precipitated sodium chloride was removed by filtration. The excess 2- amino-1-butanol distilled as light yellow oil at 83° to 87°C/13 mm. The viscous residue distilled at 165° to 170°C/0.6 mm as a light yellow oil which tended to solidify in the air condenser; yield, 108 grams.
Recrystallization by dissolving in 80 ml of hot ethanol, adding about 150 ml of petroleum ether (BP 90° to 100°C) and cooling at 5°C overnight, gave 64 grams of white crystals melting at 128° to 132.5°C. This, on recrystallization from 100 ml of 95% ethanol, gave 35 grams of white crystals melting at 134.5° to 136°C and a second crop of 10 grams melting at 132.5° to 134°C which is the meso base. Its dihydrochloride melts at 202° to 203°C.
From the ethanolic filtrates upon addition of 130 ml of about 4 N ethanolic hydrochloric acid and cooling, there was obtained 55 grams of white crystals melting at 176.5° to 178°C and a second crop of 10 grams melting at 171.5° to 174.5°C. This is the dl racemate dihydrochloride.

brand name

Myambutol (Stat Trade).

Therapeutic Function

Antitubercular

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.

Clinical Use

Antibacterial agent:
Tuberculosis

Metabolism

Ethambutol is partially metabolised in the liver to the aldehyde and dicarboxylic acid derivatives, which are inactive.
Up to 80% of a dose appears in the urine within 24 hours, 50% as unchanged drug and 8-15% as the inactive metabolites. About 20% of the dose is excreted unchanged in the faeces.

Ethambutol dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethambutol dihydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ethambutol dihydrochloride 1070-11-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%~100.5%,USP40
Supply Ability: 5tons/month
Release date: 2021-06-19

Hebei Weibang Biotechnology Co., Ltd

Product: Ethambutol dihydrochloride 1070-11-7
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-21

Hebei Chuanghai Biotechnology Co,.LTD

Product: Tetramethylammonium Chloride 1070-11-7
Price: US $10.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-20

1070-11-7, Ethambutol dihydrochloride Related Search:

N-(1-Naphthyl)ethylenediamine dihydrochloride Ethylenediamine dihydrochloride tert-Butanol Methoxyammonium chloride 1-AdaMantanethylaMine 1-Butanol DIPHENYLAMINE HYDROCHLORIDE N,N,N',N'-Tetramethylethylenediamine Ethylamine hydrochloride Ethambutol 2-Chloroethylamine hydrochloride 1-beta-D-Arabinofuranosylcytosine hydrochloride Mexiletine hydrochloride Dihydrochloride Eperisone hydrochloride Itopride hydrochloride Etilefrine hydrochloride Ethambutol Related Compound A (15 mg) ((2R,2'S)-2,2'-[ethane-1,2-diylbis(azanediyl)]dibutan-1-ol)

ETHAMBUTOL HCL USP

Emb, 2,2μ-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride

(R)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride

(S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediaMine Dihydrochloride

(2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride

Ethambutol Hydrochlorid

1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, hydrochloride (1), (2S,2'S)-

Esanbutol

Ethambutol dihydrochloride,2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride, Emb

Ethambutol Hydrochloride (200 mg)

2,2'-[1,2-Ethanediyldi(imino)]di(1-butanol) dihydrochloride

(S,S)-2,2'-(1,2-EthanediyldiiMino)-bis-1-butanol Dihydrochloride

2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride

1-Butanol, 2,2'-(ethylenediimino)di-, dihydrochloride, (+)- (8CI)

d-2,2'-(Ethylenediimino)-di-1-butanol dihydrochloride

Ebutol

Etapiam

Ethambutold dihydrochloride

Etibi

Myambutol

Mycobutol

Sural

2,2’-(1,2-ethanediyldiimino)bis-,dihydrochloride,(r-(r*,r*))-1-butano

2,2’-(ethylenediimino)di-,dihydrochloride,(+)-1-butano

cl40881

dadibutol

ETHAMBUTOL DIHYDROCHLORIDE, ANTIMYCO

[s-(r*,r*)]-2,2'-(ethylenediimino)dibutan-1-ol dihydrochloride

ETHAMBUTOL DIHYDROCHLORIDE

ETHAMBUTOL HCL

ETHAMBUTOL HYDROCHLORIDE

EMB DIHYDROCHLORIDE

ETHAMBUTOL 2HCL

EthambutolHclEthambutolHclBp

Dexambutol

(+)-2,2'-(Ethylenediimino)di-1-butanol dihydrochloride

1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, dihydrochloride, (2S,2'S)-

1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, dihydrochloride, [S-(R*,R*)]-

2,2'-(1,2-ETHANEDIYLDIIMINO)BIS-1-BUTANOL DIHYDROCHLORIDE

Ethambutol hydrochloride reference substance

Ethambutol for system suitability CRS

Ethambutol hydrochloride CRS

(S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamineDihydrochloride&gt

Ethambutol dihydrochloride USP/EP/BP

Ethambutol HCI

Ethambutol for system suitability (Y0000803)

Ethambutol HydrochlorideQ: What is Ethambutol Hydrochloride Q: What is the CAS Number of Ethambutol Hydrochloride Q: What is the storage condition of Ethambutol Hydrochloride Q: What are the applications of Ethambutol Hydrochloride

TIANFU CHEM Ethambutol dihydrochloride

Ethambutol dihydrochloride-HBW

Ethambutol Dihydrochloride (ETB.2HCl), 98%

Ethambutol Hydrochloride (1257007)

S-(R*,R*)]-2,2'-(Ethylendiimino)dibutan-1-oldihydrochlorid

(+)-S,S-Ethambutol dihydrochloride salt

Ethambutol Hydrochlorido

Myambutol dihydrochloride

(S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride, ≥ 98.0%

(2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride

DIHYDROGEN ETHAMBUTOL DICHLORIDE