Ethyl chlorooxoacetate
Uses- Product Name
- Ethyl chlorooxoacetate
- CAS No.
- 4755-77-5
- Chemical Name
- Ethyl chlorooxoacetate
- Synonyms
- Ethyl 2-chloro-2-oxoacetate;ETHYL OXALYL CHLORIDE;ETHYL CHLOROOXOACETATE;ETHYL CHLOROGLYOXYLATE;ETHOXALYL CHLORIDE;ETCOX;2-chloro-2-oxoacetate;mono-Ethyl oxalyl chloride;Ethyl (Chlorocarbonyl)formate;orooxoacetate
- CBNumber
- CB1257382
- Molecular Formula
- C4H5ClO3
- Formula Weight
- 136.53
- MOL File
- 4755-77-5.mol
Ethyl chlorooxoacetate Property
- Melting point:
- 156-158 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 135 °C
- Density
- 1.222 g/mL at 25 °C(lit.)
- refractive index
- 1.416-1.418
- Flash point:
- 41 °C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- soluble in Chloroform
- form
- Liquid
- color
- Clear
- Specific Gravity
- 1.222
- Water Solubility
- Slightly miscible with water.
- Sensitive
- Moisture Sensitive
- BRN
- 506725
- InChIKey
- OWZFULPEVHKEKS-UHFFFAOYSA-N
- CAS DataBase Reference
- 4755-77-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Chlorooxalic acid, ethyl ester(4755-77-5)
- EPA Substance Registry System
- Acetic acid, chlorooxo-, ethyl ester (4755-77-5)
Safety
- Hazard Codes
- C,F
- Risk Statements
- 34-29-20/21/22-14-10-37-36
- Safety Statements
- 8-45-36/37/39-26-16
- RIDADR
- 2920
- WGK Germany
- 3
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29171990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- E43101
- Product name
- Ethyl chlorooxoacetate
- Purity
- 98%
- Packaging
- 25g
- Price
- $46.8
- Updated
- 2025/07/31
- Product number
- E43101
- Product name
- Ethyl chlorooxoacetate
- Purity
- 98%
- Packaging
- 100g
- Price
- $103
- Updated
- 2025/07/31
- Product number
- C1066
- Product name
- Ethyl Chloroglyoxylate
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $73
- Updated
- 2025/07/31
- Product number
- C1066
- Product name
- Ethyl Chloroglyoxylate
- Purity
- >98.0%(T)
- Packaging
- 100g
- Price
- $192
- Updated
- 2025/07/31
- Product number
- E43101
- Product name
- Ethyl chlorooxoacetate
- Purity
- 98%
- Packaging
- 500g
- Price
- $141
- Updated
- 2025/07/31
Ethyl chlorooxoacetate Chemical Properties,Usage,Production
Uses
Ethyl oxalyl monochloride is used in the synthesis of 2-oxo-3-alkenoic esters and alpha-keto ester in good yield. Ethyl oxalyl monochloride acts as a reactant in the preparation of oxyoxalamide derivatives as an epoxide hydrolase inhibitor.
Description
Ethyl chlorooxoacetate has been used as a reactant in the preparation of oxyoxalamide derivatives as epoxide hydrolase inhibitors.
Chemical Properties
clear liquid
Uses
Ethyl oxalyl chloride is used in the synthesis of 2-oxo-3-alkenoic esters and alpha-keto ester in good yield. It acts as a reactant in the preparation of oxyoxalamide derivatives as an epoxide hydrolase inhibitor.
Uses
Ethyl chlorooxoacetate can be used for the synthesis of:
- α-keto esters.
- Functionalized 3-pyrolin-2-ones.
- Substituted arylglyoxylic acids via Friedel–Crafts acylation.
- Substituted 9,10-phenanthrenequinones.
- Quinoxalinone derivatives.
reaction suitability
reagent type: oxidant
Synthesis
95-92-1
4755-77-5
The general procedure for the synthesis of monoethyl oxalyl chloride from diethyl oxalate was as follows: a mixture of potassium acetate (20 g), water (30 mL) and diethyl oxalate (29.2 g, 0.2 mol) was stirred and reacted for 2 hours at 70-80 °C. Upon completion of the reaction, the reaction mixture was cooled and concentrated to 30 mL. Subsequently, ethanol (50 mL) and ether (150 mL) were added and the mixed solution was filtered to afford 23.61 g of potassium monoethyl oxalate (76% yield). The dried potassium monoethyl oxalate (20.6 g, 0.13 mol) was pre-mixed with diethyl ether (20 mL) in an ice bath and SOCl2 (30 g, 0.25 mol) was added slowly. The reaction mixture was heated under reflux conditions for 15 hours. At the end of the reaction, the resulting white solid of potassium chloride was removed by filtration, the filtrate was separated and the 125-130 °C fraction was collected by distillation to give 12.22 g of monoethyl oxalyl chloride (69% yield).
References
[1] Gazzetta Chimica Italiana, 1891, vol. 21 I, p. 306
[2] Monatshefte fuer Chemie, 1905, vol. 26, p. 375
[3] Chemische Berichte, 1886, vol. 19, p. 2159
[4] Justus Liebigs Annalen der Chemie, 1889, vol. 254, p. 27
[5] Recueil des Travaux Chimiques des Pays-Bas, 1907, vol. 26, p. 381
Ethyl chlorooxoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl chlorooxoacetate Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
- ProdList
- 6700
- Advantage
- 60
View Lastest Price from Ethyl chlorooxoacetate manufacturers
- Product
- Ethyl oxalyl monochloride 4755-77-5
- Price
- US $1.00-1.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-08-16
- Product
- Ethyl oxalyl monochloride 4755-77-5
- Price
- US $8.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-22
- Product
- Ethyl oxalyl monochloride 4755-77-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%min
- Supply Ability
- 10000kg
- Release date
- 2023-06-09