ChemicalBook > CAS DataBase List > 6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol

6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol

Product Name
6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol
CAS No.
226907-52-4
Chemical Name
6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol
Synonyms
1V136;CL087;SM360320;SM360320, 10 mM in DMSO;SM-360320?(Synonyms: CL-087);Toll-Like Receptor 7 Ligand II;6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol;6-Amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-8H-purin-8-one;8H-Purin-8-one, 6-amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-;TLR7,Inhibitor,Th1,Toll-like Receptor (TLR),SM360320,antitumor effect,oral,DNA vaccines,inhibit
CBNumber
CB12582994
Molecular Formula
C15H17N5O3
Formula Weight
315.33
MOL File
226907-52-4.mol
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6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol Property

Density 
1.356
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17228
Product name
Toll-Like Receptor 7 Ligand II
Purity
≥98%
Packaging
500μg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
17228
Product name
Toll-Like Receptor 7 Ligand II
Purity
≥98%
Packaging
1mg
Price
$290
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
API0014408
Product name
6-AMINO-9-BENZYL-2-(2-METHOXYETHOXY)-9H-PURIN-8-OL
Purity
95.00%
Packaging
5MG
Price
$495.23
Updated
2021/12/16
Matrix Scientific
Product number
093250
Product name
6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
Purity
95+%
Packaging
250mg
Price
$1286
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0014408
Product name
6-AMINO-9-BENZYL-2-(2-METHOXYETHOXY)-9H-PURIN-8-OL
Purity
95.00%
Packaging
250MG
Price
$2033.85
Updated
2021/12/16
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6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol Chemical Properties,Usage,Production

Uses

SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].

References

[1] Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16(5):462-472. DOI:10.1038/cgt.2008.91
[2] Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833. DOI:10.1073/pnas.0510801103

6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol Suppliers

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226907-52-4, 6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-olRelated Search:

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  • 6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol
  • 6-Amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-8H-purin-8-one
  • CL087
  • SM360320
  • Toll-Like Receptor 7 Ligand II
  • 8H-Purin-8-one, 6-amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-
  • SM-360320?(Synonyms: CL-087)
  • 1V136
  • TLR7,Inhibitor,Th1,Toll-like Receptor (TLR),SM360320,antitumor effect,oral,DNA vaccines,inhibit
  • SM360320, 10 mM in DMSO
  • 226907-52-4
  • 116396-23-4