(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone

Product Name: (4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone
CAS No.: 432020-20-7
Chemical Name: (4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone
Synonyms: SMI481;NPPM6748481;NPPM 6748481;NPPM-6748-481;NPPM 6748-481;SID: 164348711;SMI-481 SMI 481;SMI481, 10 mM in DMSO;Inhibitor,SMI481,SMI-481,inhibit;1-(4-Chloro-3-nitrobenzoyl)-4-(2-fluorophenyl)-piperazine
CBNumber: CB52715743
Molecular Formula: C17H15ClFN3O3
Formula Weight: 363.7707032
MOL File: 432020-20-7.mol

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(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone Property

Boiling point:: 543.3±50.0 °C(Predicted)
Density: 1.411±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear
pka: 1.04±0.10(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1090
Product name: SMI481
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $102
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML1090
Product name: SMI481
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $410
Updated: 2022/05/15

Cayman Chemical

Product number: 17637
Product name: SMI-481
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17637
Product name: SMI-481
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 17637
Product name: SMI-481
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

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(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone Chemical Properties,Usage,Production

Uses

SMI-481 is a yeast phosphatidylinositol transfer proteins (PITP) Sec14 inhibitor.

Biological Activity

SMI481 is a selective small-molecule inhibitor (SMI) of the yeast phosphatidylinositol transfer protein (PITP) Sec14, a key regulator of phosphoinositide signaling, regulating membrane trafficking through the trans-Golgi network and endosomal systems. SMI481 has an IC50 value of 211 ± 19 nM in vitro against S. cerevisiae Sec14 (WT) in a phosphatidylinositol (PtdIns) transfer assay measuring exchange of PtdIns and phosphatidylcholine between membranes and inhibited Sec14-dependent growth of WT yeast with an IC50 of 2.87 ± 0.55 μM. SMI481μs activity is believed to involve binding in the Sec14 hydrophobic cavity, a new target for studying phosphoinositide signaling with more selectivity than th at afforded by lipid kinase–directed strategies.

(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone Suppliers

China 30 United Kingdom 1 United States 7 USA 1 Global 39

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432020-20-7, (4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)MethanoneRelated Search:

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(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone

1-(4-Chloro-3-nitrobenzoyl)-4-(2-fluorophenyl)-piperazine

SID: 164348711

SMI481

Methanone, (4-chloro-3-nitrophenyl)[4-(2-fluorophenyl)-1-piperazinyl]-

NPPM 6748481

NPPM 6748-481

NPPM6748481

NPPM-6748-481

SMI-481 SMI 481

Inhibitor,SMI481,SMI-481,inhibit

SMI481, 10 mM in DMSO

432020-20-7