6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol

Product Name: 6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol
CAS No.: 226907-52-4
Chemical Name: 6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol
Synonyms: 1V136;CL087;SM360320;SM360320, 10 mM in DMSO;SM-360320?(Synonyms: CL-087);Toll-Like Receptor 7 Ligand II;6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol;6-Amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-8H-purin-8-one;8H-Purin-8-one, 6-amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-;TLR7,Inhibitor,Th1,Toll-like Receptor (TLR),SM360320,antitumor effect,oral,DNA vaccines,inhibit
CBNumber: CB12582994
Molecular Formula: C15H17N5O3
Formula Weight: 315.33
MOL File: 226907-52-4.mol

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6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol Property

Density: 1.356
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17228
Product name: Toll-Like Receptor 7 Ligand II
Purity: ≥98%
Packaging: 500μg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 17228
Product name: Toll-Like Receptor 7 Ligand II
Purity: ≥98%
Packaging: 1mg
Price: $290
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0014408
Product name: 6-AMINO-9-BENZYL-2-(2-METHOXYETHOXY)-9H-PURIN-8-OL
Purity: 95.00%
Packaging: 5MG
Price: $495.23
Updated: 2021/12/16

Matrix Scientific

Product number: 093250
Product name: 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
Purity: 95+%
Packaging: 250mg
Price: $1286
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0014408
Product name: 6-AMINO-9-BENZYL-2-(2-METHOXYETHOXY)-9H-PURIN-8-OL
Purity: 95.00%
Packaging: 250MG
Price: $2033.85
Updated: 2021/12/16

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6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol Chemical Properties,Usage,Production

Uses

SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].

References

[1] Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16(5):462-472. DOI:10.1038/cgt.2008.91
[2] Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833. DOI:10.1073/pnas.0510801103

6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol Suppliers

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226907-52-4, 6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-olRelated Search:

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6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol

6-Amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-8H-purin-8-one

CL087

SM360320

Toll-Like Receptor 7 Ligand II

8H-Purin-8-one, 6-amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-

SM-360320?(Synonyms: CL-087)

1V136

TLR7,Inhibitor,Th1,Toll-like Receptor (TLR),SM360320,antitumor effect,oral,DNA vaccines,inhibit

SM360320, 10 mM in DMSO

226907-52-4

116396-23-4