SM-276001

Product Name: SM-276001
CAS No.: 473930-22-2
Chemical Name: SM-276001
Synonyms: SM-276001;SM-276001, 10 mM in DMSO;6-Amino-2-(butylamino)-9-((6-methylpyridin-3-yl)methyl)-7,9-dihydro-8H-purin-8-one;8H-Purin-8-one, 6-amino-2-(butylamino)-7,9-dihydro-9-[(6-methyl-3-pyridinyl)methyl]-;immune,SM-276001,IFNAR,Interferon-alpha/beta receptor,IFN,Toll-like Receptor (TLR),SM276001,inhibit,TLR7,Inhibitor,Interferon-α/β receptor,interferon,SM 276001,antitumor
CBNumber: CB86215158
Molecular Formula: C16H21N7O
Formula Weight: 327.38
MOL File: 473930-22-2.mol

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SM-276001 Property

Melting point:: 248.5-252 °C(Solv: methanol (67-56-1))
Density: 1.322±0.06 g/cm3(Predicted)
pka: 10.30±0.20(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0082346
Product name: SM-276001
Purity: 99.71%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0082346
Product name: SM-276001
Purity: 99.71%
Packaging: 10mg
Price: $580
Updated: 2021/12/16

ChemScene

Product number: CS-0082346
Product name: SM-276001
Purity: 99.71%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0082346
Product name: SM-276001
Purity: 99.71%
Packaging: 100mg
Price: $2450
Updated: 2021/12/16

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SM-276001 Chemical Properties,Usage,Production

Description

SM-276001 is a selective and potent TLR7 agonist. SM-276001 is can induce antitumor immune responses when dosed either intratracheally or orally. Oral administration of SM-276001 leads to the induction of IFNα, TNFα and IL-12p40 and a reduction in tumor burden in the Balb/c syngeneic Renca and CT26 models.

Uses

SM-276001 is a potent selective TLR7 agonist that can induce antitumor immune responses. SM-276001 is an orally active interferon (IFN) inducer[1][2].

in vivo

SM-276001 demonstrates potent IFN-inducing activity at a dose of 0.1 mg/kg by oral administration in mice^[1].
Oral administration of SM-276001, leads to the induction of an inflammatory cytokine and chemokine milieu and to the activation of a diverse population of immune effector cells including T and B lymphocytes, NK and NKT cells^[2].
SM-276001 (3 mg/kg PO biweekly) significantly inhibits tumor growth in the Renca renal cell cancer and CT26 colorectal models^[2].
SM-276001 (orally; 0.1, 1 or 10 mg/kg) leads to the activation of a diverse population of spleen-resident immune effector cells in Balb/c and C57BL/6J mice. When administered at 1 mg/kg or greater, the plasma concentration of SM-276001 exceeds the MEC of 30 nM^[2].

Animal Model:	C57BL/6 and B6C3F1 mice bearing Renca or CT26 tumors^[2]
Dosage:	3 mg/kg
Administration:	Oral administration twice weekly for 25 days
Result:	Significantly reduced disease burden in mice bearing either Renca or CT26 tumors.

References

[1] Isobe Y, et al. Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers. J Med Chem. 2006 Mar 23;49(6):2088-95. DOI:10.1021/jm051089s
[2] Koga-Yamakawa E, et al. Intratracheal and oral administration of SM-276001: a selective TLR7 agonist, leads to antitumor efficacy in primary and metastatic models of cancer. Int J Cancer. 2013 Feb 1;132(3):580-90. DOI:10.1002/ijc.27691

SM-276001 Preparation Products And Raw materials

Raw materials

Preparation Products

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SM-276001 Suppliers

China 21 United States 3 Global 24

Shanghai Raise Chemical Technology Co.,Ltd

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Suzhou Zhixin Biotechnology Co., Ltd.

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473930-22-2, SM-276001Related Search:

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SM-276001

immune,SM-276001,IFNAR,Interferon-alpha/beta receptor,IFN,Toll-like Receptor (TLR),SM276001,inhibit,TLR7,Inhibitor,Interferon-α/β receptor,interferon,SM 276001,antitumor

8H-Purin-8-one, 6-amino-2-(butylamino)-7,9-dihydro-9-[(6-methyl-3-pyridinyl)methyl]-

SM-276001, 10 mM in DMSO

6-Amino-2-(butylamino)-9-((6-methylpyridin-3-yl)methyl)-7,9-dihydro-8H-purin-8-one

473930-22-2