ChemicalBook > CAS DataBase List > 4-Hydroxytolbutamide

4-Hydroxytolbutamide

Product Name
4-Hydroxytolbutamide
CAS No.
5719-85-7
Chemical Name
4-Hydroxytolbutamide
Synonyms
HYDROXY TOLBUTAMIDE;Tolbutamide Hydroxy;4-HYDROXYTOLBUTAMIDE;Tolbutamide Impurity 4;hydroxymethyltolbutamide;HydroxyMethylcarbutaMide;HydroxyMethylcarbutaMide Impurity;4-Hydroxytolbutamide solution ;4-Hydroxytolbutamide Solution, 100ppm;1-Butyl-3-(p-hydroxyMethylphenyl)sulfonylurea
CBNumber
CB1258804
Molecular Formula
C12H18N2O4S
Formula Weight
286.35
MOL File
5719-85-7.mol
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4-Hydroxytolbutamide Property

Melting point:
100-102 °C
Density 
1.268±0.06 g/cm3(Predicted)
Flash point:
2℃
storage temp. 
2-8°C
solubility 
ethanol: 12 mg/mL
pka
4.96±0.10(Predicted)
form 
Solid
color 
white
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Safety

Hazard Codes 
F,Xn
Risk Statements 
11-20/21/22-36
Safety Statements 
16-36/37-24/25
RIDADR 
UN 1648 3 / PGII
WGK Germany 
3
HS Code 
29350090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
UC160
Product name
4-Hydroxytolbutamide
Purity
≥98% (HPLC)
Packaging
5mg
Price
$896
Updated
2024/03/01
Cayman Chemical
Product number
10008520
Product name
4-hydroxy Tolbutamide
Purity
≥98%
Packaging
1mg
Price
$41
Updated
2024/03/01
Cayman Chemical
Product number
10008520
Product name
4-hydroxy Tolbutamide
Purity
≥98%
Packaging
5mg
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
UC160
Product name
4-Hydroxytolbutamide
Purity
≥98% (HPLC)
Packaging
10mg
Price
$1660
Updated
2024/03/01
Cayman Chemical
Product number
10008520
Product name
4-hydroxy Tolbutamide
Purity
≥98%
Packaging
10mg
Price
$286
Updated
2024/03/01
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4-Hydroxytolbutamide Chemical Properties,Usage,Production

Description

4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker. Tolbutamide 4-hydroxylation is an often used probe reaction in the pharmaceutical industry for the characterization of CYP2C8 and CYP2C9 involvement in the metabolism of clinical drugs.

Chemical Properties

White Solid

Uses

A metabolite of Tolbutamide. Formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes

Uses

4-Hydroxytolbutamide has been used as a standard to assay the fungal biotransformation of tolbutamide to 4′-hydroxytolbutamide.

Definition

ChEBI: A urea that consists of 1-butylurea having a 4-hydroxymethylbenzenesulfonyl group attached at the 3-position.

4-Hydroxytolbutamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxytolbutamide Suppliers

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5719-85-7, 4-HydroxytolbutamideRelated Search:

3-Aminobenzenesulfonamide Sulfanilamide Tosyl chloride Benzenesulfonamide N-n-Butyl benzene sulfonamide Butylated Hydroxytoluene p-Toluenesulfonamide Tris(hydroxymethyl)aminomethane Tosyl cyanide TOLBUTAMIDE Tolbutamide-d9 TOLAZAMIDE 4-Carboxytolbutamide Methyl Ester Tolbutamide 4-Carboxy Ethyl Ester Tolbutamide Impurity 5 L-ACYLASE CARBOXYTOLBUTAMIDE-D9 (BUTYL-D9) CARBOXYTOLBUTAMIDE

  • 4-HYDROXYTOLBUTAMIDE
  • HYDROXY TOLBUTAMIDE
  • N-(BUTYLAMINOCARBONYL)-4-HYDROXYMETHYLBENZENESULFONAMIDE
  • N-(Butylamnocarbonyl)-4-hydroxymethylbenzenesulfonamide
  • hydroxymethyltolbutamide
  • 4-Hydroxytolbutamide,N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide
  • 1-Butyl-3-(p-hydroxyMethylphenyl)sulfonylurea
  • HydroxyMethylcarbutaMide
  • 4-Hydroxytolbutamide solution
  • N-(butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide
  • 1-butyl-3-[4-(hydroxymethyl)phenyl]sulfonylurea
  • 4-Hydroxytolbutamide Solution, 100ppm
  • Tolbutamide Hydroxy
  • Benzenesulfonamide, N-[(butylamino)carbonyl]-4-(hydroxymethyl)-
  • Tolbutamide Impurity 4
  • HydroxyMethylcarbutaMide Impurity
  • 5719-85-7
  • C12H18N2O4S
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