4-Hydroxytolbutamide

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4-Hydroxytolbutamide

Product Name: 4-Hydroxytolbutamide
CAS No.: 5719-85-7
Chemical Name: 4-Hydroxytolbutamide
Synonyms: HYDROXY TOLBUTAMIDE;Tolbutamide Hydroxy;4-HYDROXYTOLBUTAMIDE;Tolbutamide Impurity 4;hydroxymethyltolbutamide;HydroxyMethylcarbutaMide;HydroxyMethylcarbutaMide Impurity;4-Hydroxytolbutamide solution ;4-Hydroxytolbutamide Solution, 100ppm;1-Butyl-3-(p-hydroxyMethylphenyl)sulfonylurea
CBNumber: CB1258804
Molecular Formula: C12H18N2O4S
Formula Weight: 286.35
MOL File: 5719-85-7.mol

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4-Hydroxytolbutamide Property

Melting point:: 100-102 °C
Density: 1.268±0.06 g/cm3(Predicted)
Flash point:: 2℃
storage temp.: 2-8°C
solubility: ethanol: 12 mg/mL
pka: 4.96±0.10(Predicted)
form: Solid
color: white

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Safety

Hazard Codes: F,Xn
Risk Statements: 11-20/21/22-36
Safety Statements: 16-36/37-24/25
RIDADR: UN 1648 3 / PGII
WGK Germany: 3
HS Code: 29350090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: UC160
Product name: 4-Hydroxytolbutamide
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $896
Updated: 2024/03/01

Cayman Chemical

Product number: 10008520
Product name: 4-hydroxy Tolbutamide
Purity: ≥98%
Packaging: 1mg
Price: $41
Updated: 2024/03/01

Cayman Chemical

Product number: 10008520
Product name: 4-hydroxy Tolbutamide
Purity: ≥98%
Packaging: 5mg
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: UC160
Product name: 4-Hydroxytolbutamide
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $1660
Updated: 2024/03/01

Cayman Chemical

Product number: 10008520
Product name: 4-hydroxy Tolbutamide
Purity: ≥98%
Packaging: 10mg
Price: $286
Updated: 2024/03/01

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4-Hydroxytolbutamide Chemical Properties,Usage,Production

Description

4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker. Tolbutamide 4-hydroxylation is an often used probe reaction in the pharmaceutical industry for the characterization of CYP2C8 and CYP2C9 involvement in the metabolism of clinical drugs.

Chemical Properties

White Solid

Uses

A metabolite of Tolbutamide. Formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes

Uses

4-Hydroxytolbutamide has been used as a standard to assay the fungal biotransformation of tolbutamide to 4′-hydroxytolbutamide.

Definition

ChEBI: A urea that consists of 1-butylurea having a 4-hydroxymethylbenzenesulfonyl group attached at the 3-position.

4-Hydroxytolbutamide Preparation Products And Raw materials

Raw materials

Preparation Products

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5719-85-7, 4-HydroxytolbutamideRelated Search:

3-Aminobenzenesulfonamide Sulfanilamide Tosyl chloride Benzenesulfonamide N-n-Butyl benzene sulfonamide Butylated Hydroxytoluene p-Toluenesulfonamide Tris(hydroxymethyl)aminomethane Tosyl cyanide TOLBUTAMIDE Tolbutamide-d9 TOLAZAMIDE 4-Carboxytolbutamide Methyl Ester Tolbutamide 4-Carboxy Ethyl Ester Tolbutamide Impurity 5 L-ACYLASE CARBOXYTOLBUTAMIDE-D9 (BUTYL-D9) CARBOXYTOLBUTAMIDE

4-HYDROXYTOLBUTAMIDE

HYDROXY TOLBUTAMIDE

N-(BUTYLAMINOCARBONYL)-4-HYDROXYMETHYLBENZENESULFONAMIDE

N-(Butylamnocarbonyl)-4-hydroxymethylbenzenesulfonamide

hydroxymethyltolbutamide

4-Hydroxytolbutamide,N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide

1-Butyl-3-(p-hydroxyMethylphenyl)sulfonylurea

HydroxyMethylcarbutaMide

4-Hydroxytolbutamide solution

N-(butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide

1-butyl-3-[4-(hydroxymethyl)phenyl]sulfonylurea

4-Hydroxytolbutamide Solution, 100ppm

Tolbutamide Hydroxy

Benzenesulfonamide, N-[(butylamino)carbonyl]-4-(hydroxymethyl)-

Tolbutamide Impurity 4

HydroxyMethylcarbutaMide Impurity

5719-85-7

C12H18N2O4S

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