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NVP-LCQ195

Product Name
NVP-LCQ195
CAS No.
902156-99-4
Chemical Name
NVP-LCQ195
Synonyms
LCQ-195;LCQ 195;AT-9311;AT 9311;NVP-LCQ195;NVP-LCQ195 (AT9311;NVP-LCQ195, 10 mM in DMSO;NVP-LCQ195 (AT9311; LCQ195);NVP-LCQ195;LCQ-195;AT-9311;NVP LCQ195;LCQ-195;AT-9311;NVP LCQ195;LCQ 195;AT9311;AT 9311
CBNumber
CB12628205
Molecular Formula
C17H19Cl2N5O4S
Formula Weight
460.33486
MOL File
902156-99-4.mol
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NVP-LCQ195 Property

Density 
1.57±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥152.4 mg/mL in DMSO; ≥3.28 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
pka
11.10±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0840
Product name
NVP-LCQ195
Purity
99.80%
Packaging
5mg
Price
$230
Updated
2021/12/16
ApexBio Technology
Product number
A3676
Product name
NVP-LCQ195
Packaging
5mg
Price
$256
Updated
2021/12/16
ChemScene
Product number
CS-0840
Product name
NVP-LCQ195
Purity
99.80%
Packaging
10mg
Price
$330
Updated
2021/12/16
ApexBio Technology
Product number
A3676
Product name
NVP-LCQ195
Packaging
10mg
Price
$359
Updated
2021/12/16
Acrotein
Product number
UT00063
Product name
Nvp-lcq195
Purity
97%
Packaging
25mg
Price
$666.67
Updated
2021/12/16
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NVP-LCQ195 Chemical Properties,Usage,Production

Uses

NVP-LCQ195 (AT9311; LCQ195) is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM. IC50 Value: 1 nM(CDK5/p25 and CDK5/p35); 2 nM(CDK1/cyclinB and CDK2/cyclinA); 5 nM(CDK2/cyclinE); 42 nM(CDK3/cyclinE) Target: CDKs LCQ195 induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-lmol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. In MM cells, LCQ195 triggered decreased amplitude of transcriptional signatures associated with oncogenesis, drug resistance and stem cell renewal, including signatures of activation of key transcription factors for MM cells e.g. myc, HIF-1a, IRF4. Bortezomib-treated MM patients whose tumours had high baseline expression of genes suppressed by LCQ195 had significantly shorter progression-free and overall survival than those with low levels of these transcripts in their MM cells. These observations provide insight into the biological relevance of multi-targeted CDK inhibition in MM.

IC 50

Cdk5/p25: 1 nM (IC50); CDK5/p35: 1 nM (IC50); Cdk1/cyclin B: 2 nM (IC50); cdk2/cyclin A: 2 nM (IC50); CDK2/cyclinE: 5 nM (IC50); CDK9/cyclinT1: 15 nM (IC50); CDK3/Cyclin E: 42 nM (IC50); cdk6/cyclin D3: 187 nM (IC50); CDK7/Cyclin H/MAT1: 3564 nM (IC50)

References

[1] McMillin DW, Delmore J, Negri J et al. Molecular and cellular effects of multi-targeted cyclin-dependent kinase inhibition in myeloma: biological and clinical implications. Br J Haematol. 2011 Feb;152(4):420-32. DOI:10.1111/j.1365-2141.2010.08427.x

NVP-LCQ195 Preparation Products And Raw materials

Raw materials

Preparation Products

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NVP-LCQ195 Suppliers

China 73 United States 8 Global 81
MedChemexpress LLC
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TargetMol Chemicals Inc.
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MedChemExpress
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902156-99-4, NVP-LCQ195Related Search:

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  • AT 9311
  • AT-9311
  • LCQ 195
  • LCQ-195
  • 4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid N-[1-(methylsulfonyl)piperidin-4-yl]amide
  • NVP-LCQ195 (AT9311
  • NVP-LCQ195 (AT9311; LCQ195)
  • LCQ-195;AT-9311;NVP LCQ195;LCQ 195;AT9311;AT 9311
  • 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid (1-methanesulphonyl-piperidin-4-yl)-amide
  • 1H-Pyrazole-3-carboxamide, 4-[(2,6-dichlorobenzoyl)amino]-N-[1-(methylsulfonyl)-4-piperidinyl]-
  • NVP-LCQ195,AT-9311,NVPLCQ195,NVP-LCQ-195,inhibit,Cyclin dependent kinase,Inhibitor,AT 9311,NVP LCQ195,LCQ195,CDK,LCQ 195
  • NVP-LCQ195, 10 mM in DMSO
  • 4-[(2,6-dichlorobenzoyl)amino]-N-(1-methylsulfonylpiperidin-4-yl)-1H-pyrazole-5-carboxamide
  • 902156-99-4
  • C17H19Cl2N5O4S