3,5-Difluoroanisole
- Product Name
- 3,5-Difluoroanisole
- CAS No.
- 93343-10-3
- Chemical Name
- 3,5-Difluoroanisole
- Synonyms
- 3-difluoroanisile;3,5-DIFLUOROANISOLE;3，5-difluoroanisile;3,5-two fluorineether;3,5-Difluoroanisole98%;3,5-Difluoroanisole>3,5-Difluoroanisole 98%;3,5-Difluoroanisole,97%;3,5- difluorobenzyl ether;1,3-difluoro-5-Methoxybenzene
- CBNumber
- CB1263266
- Molecular Formula
- C7H6F2O
- Formula Weight
- 144.12
- MOL File
- 93343-10-3.mol
3,5-Difluoroanisole Property
- Boiling point:
- 145-148°C
- Density
- 1.234 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.466(lit.)
- Flash point:
- 111 °F
- storage temp.
- Sealed in dry,2-8°C
- form
- Liquid
- Specific Gravity
- 1.234
- color
- Clear colorless
- BRN
- 4966844
- CAS DataBase Reference
- 93343-10-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,F
- Risk Statements
- 10-36/37/38
- Safety Statements
- 16-26-36/37/39-7/9
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- Hazard Note
- Flammable
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29093090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D2463
- Product name
- 3,5-Difluoroanisole
- Purity
- >97.0%(GC)
- Packaging
- 10g
- Price
- $134
- Updated
- 2025/07/31
- Product number
- D445395
- Product name
- 3,5-Difluoroanisole
- Packaging
- 10g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- D445395
- Product name
- 3,5-Difluoroanisole
- Packaging
- 100g
- Price
- $625
- Updated
- 2021/12/16
- Product number
- 2607-3-08
- Product name
- 3,5-Difluoroanisole
- Purity
- 98%
- Packaging
- 5G
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 005152
- Product name
- 3,5-Difluoroanisole
- Purity
- 98%
- Packaging
- 5g
- Price
- $18
- Updated
- 2021/12/16
3,5-Difluoroanisole Chemical Properties,Usage,Production
Chemical Properties
clear colorless liquid
Uses
3,5-Difluoroanisole is used in the preparation of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists. Also used in the preparation of imidazo[1,5-a]pyrido[3,2-e]pyrazines and imidazo[1,5-a]quinoxalines as orally active phosphodiesterase 10A inhibitors.
General Description
The structure and vibrations of 3,5-difluoroanisole in first electronically excited state were studied by mass-analyzed resonant two-photon ionization technique as well as the quantum chemical calculations.
Synthesis
2713-34-0
74-88-4
93343-10-3
To a stirred suspension of 3,5-difluorophenol (12.5 g, 96 mmol) and potassium carbonate (66.0 g, 480 mmol) in acetone (400 mL) was added methyl iodide (27 mL, 480 mmol) in a single addition. The reaction mixture was then heated to reflux at 60 °C for 18 hours. After cooling to room temperature, the excess solvent was evaporated under reduced pressure, 150 mL of water was added and extracted with ether (2 x 300 mL). The combined organic layers were washed sequentially with 0.1 M sodium hydroxide solution (100 mL) and water (100 mL), dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 3,5-difluoroanisole (12.0 g, 80% yield) as a colorless oil.1H-NMR (400 MHz, CDCl3) δppm: 3.81 (s, 3H), 6.43- 6.46 (m, 3H).
References
[1] Tetrahedron Letters, 2004, vol. 45, # 1, p. 95 - 98
[2] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00138
[3] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00140
[4] Patent: US6149990, 2000, A
3,5-Difluoroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-Difluoroanisole Suppliers
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- 320-37350700
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View Lastest Price from 3,5-Difluoroanisole manufacturers
- Product
- 3,5-Difluoroanisole 93343-10-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-09
- Product
- 3,5-Difluoroanisole 93343-10-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-17
- Product
- 3,5-Difluoroanisole 93343-10-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11