2-Chlorothiophene Property

Melting point:

-71.9 °C

Boiling point:

127-129 °C (lit.)

Density 

1.286 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.547(lit.)

Flash point:

73 °F

storage temp. 

2-8°C

solubility 

soluble in Chloroform

form 

Liquid

color 

Clear colorless to light brown

Specific Gravity

1.286

Water Solubility 

INSOLUBLE

BRN 

104652

Stability:

Volatile

InChIKey

GSFNQBFZFXUTBN-UHFFFAOYSA-N

CAS DataBase Reference

96-43-5(CAS DataBase Reference)

NIST Chemistry Reference

Thiophene, 2-chloro-(96-43-5)

EPA Substance Registry System

Thiophene, 2-chloro- (96-43-5)

Safety

Hazard Codes 

Xi,F,T

Risk Statements 

10-36/37/38-23/24/25-37

Safety Statements 

16-26-36-45-38-36/37/39-28B-7/9

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

RTECS 

XM8575000

Hazard Note 

Irritant

TSCA 

T

HazardClass 

3

PackingGroup 

II

HS Code 

29349990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H225Highly Flammable liquid and vapour

H226Flammable liquid and vapour

H301Toxic if swalloed

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

2-Chlorothiophene Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liquid

Uses

2-Chlorothiophene was used in the preparation of 5-phenylthiophene derivative.

Application

2-Chlorothiophene is a heterocyclic compound that belongs to the group of organic compounds called thiophenes. It is an effective analgesic and anti-inflammatory drug that has been used in the treatment of inflammatory bowel disease. 2-Chlorothiophene is used as a reagent in chemical synthesis, especially the preparation of pharmaceutical preparations. This compound can be prepared by photoelectron or hydrochloric acid. The suzuki coupling reaction with pyrimidine compounds is another method for synthesizing this compound.

General Description

The photodissociation dynamics of 2-chlorothiophene was studied using resonance enhanced multiphoton ionization (REMPI) time-of-flight (TOF) technique.

Purification Methods

Purify it by fractional distillation at atmospheric pressure or by gas chromatography. [Conde et al. Synthesis 412 1976, Beilstein 17/1 V 303.]