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6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine

Product Name
6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine
CAS No.
1262888-28-7
Chemical Name
6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine
Synonyms
C43;CS-1649;Spautin-1;SPAUTIN-1;SPAUTIN1;Spautin 1 - MBCQ derivative C43;4-((4-Fluorobenzyl)amino)-6-fluoroquinazoline;6-Fluoro-N-(4-fluorobenzyl)-4-quinazolinamine;6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine;6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine 98+%;6-Fluoro-N-[(4-fluorophenyl)methyl]quinazolin-4-amine
CBNumber
CB12658835
Molecular Formula
C15H11F2N3
Formula Weight
271.26
MOL File
1262888-28-7.mol
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6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine Property

Melting point:
211 °C
Boiling point:
419.6±40.0 °C(Predicted)
Density 
1.366±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble15mg/mL (clear solution)
pka
5.75±0.50(Predicted)
form 
powder
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
22-41
Safety Statements 
26-39
WGK Germany 
3
HS Code 
2922390090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0440
Product name
Spautin-1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$127
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0440
Product name
Spautin-1
Purity
≥98% (HPLC)
Packaging
25mg
Price
$202
Updated
2024/03/01
TCI Chemical
Product number
P2613
Product name
Spautin-1
Packaging
10MG
Price
$162
Updated
2024/03/01
TCI Chemical
Product number
P2613
Product name
Spautin-1
Packaging
50MG
Price
$560
Updated
2024/03/01
Cayman Chemical
Product number
17769
Product name
Spautin-1
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
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6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine Chemical Properties,Usage,Production

Description

Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes.1?Deranges dengue virion maturation.2?Spautin-1 inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells.3?Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency.4?Cell permeable.

Uses

Spautin-1 is a potent pharmacological autophagy inhibitor that promotes UVB-induced tumorigenesis. It is also a small-molecule drug that modulate autophagic pathways in different types of cancer.

Uses

Spautin-1 has been used as an autophagy inhibitor:

  • to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model
  • to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin
  • to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay

Biochem/physiol Actions

Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy.

in vitro

spautin-1 promotes the degradation of vps34 pi3 kinase complexes via inhibiting two ubiquitinspecific peptidases, usp10 and usp13, that target the beclin1 subunit of vps34 complexes. spautin-1 had no effect on the growth and survival of bcap-37 cells under normal culture conditions but dramatically enhanced cell death in glucose-free media. under glucose-free conditions, western blotting for lc3 further confirmed that autophagy was induced, which was inhibited by spautin-1. similar results were obtained with mcf-7 and bt549 cells. therefore, spautin-1 can sensitize tumor cells to apoptosis under nutritional deprived conditions [1].

IC 50

0.6 and 0.7 μm for usp10 and usp13 activity, respectively

storage

Store at +4°C

References

1) Liu et al. (2011), Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13; Cell, 147 223 2) Mateo et al. (2013), Inhibition of cellular autophagy deranges dengue virion maturation; J. Virol., 87 1312 3) Correa et al. (2014), Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability; Carcinogenesis,?35 1951 4) Vakifahmetoglu-Norburg et al. (1987), Chaperone-mediated autophagy degrades mutant p53; Genes Dev., 27 1718

6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine Suppliers

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1262888-28-7, 6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMineRelated Search:

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  • 6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine
  • 6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
  • C43
  • 4-((4-Fluorobenzyl)amino)-6-fluoroquinazoline
  • Spautin-1
  • 6-Fluoro-N-(4-fluorobenzyl)-4-quinazolinamine
  • 6-Fluoro-N-[(4-fluorophenyl)methyl]quinazolin-4-amine
  • Spautin 1 - MBCQ derivative C43
  • CS-1649
  • SPAUTIN-1;SPAUTIN1
  • 6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine 98+%
  • 4-Quinazolinamine, 6-fluoro-N-[(4-fluorophenyl)methyl]-
  • 1262888-28-7
  • Inhibitors