UNC-0642

ChemicalBook > CAS DataBase List > UNC-0642

Product Name: UNC-0642
CAS No.: 1481677-78-4
Chemical Name: UNC-0642
Synonyms: CS-1714;UNC0642;UNC 0642;UNC-0642;UNC-0642;UNC0642;UNC 0642;UNC0642,inhibit,Inhibitor,Histone Methyltransferase;2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine;2-(4,4-Difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine;2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine;4-Quinazolinamine, 2-(4,4-difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-
CBNumber: CB12668368
Molecular Formula: C29H44F2N6O2
Formula Weight: 546.7
MOL File: 1481677-78-4.mol

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UNC-0642 Property

Boiling point:: 679.2±65.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
form: powder
pka: 10.06±0.20(Predicted)
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1037
Product name: UNC0642
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $216
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1037
Product name: UNC0642
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $519
Updated: 2024/03/01

Cayman Chemical

Product number: 14604
Product name: UNC0642
Purity: ≥95%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 14604
Product name: UNC0642
Purity: ≥95%
Packaging: 5mg
Price: $180
Updated: 2024/03/01

Cayman Chemical

Product number: 14604
Product name: UNC0642
Purity: ≥95%
Packaging: 10mg
Price: $270
Updated: 2024/03/01

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UNC-0642 Chemical Properties,Usage,Production

Uses

UNC 0642 is an in vivo chemical probe of the lysine methyltransferases G9a and GLP which maintains high in vitro and cellular potency, low cell toxicity, and selectivity.

Biochem/physiol Actions

UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a (EHMT2) and GLP (EHMT1), which catalyze the mono and dimethylation of lysine 9 of histone 3 (H3K9), and other non-histone substrates such as p53 and WIZ. UNC0642 has an in vitro IC50 <15 nM with greater than 100-fold selectivity over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC0642 has the same potency with improved PK properties relative to UNC0638, which should make it a more useful probe in an in vivo setting. For full characterization details, please visit the UNC0642 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at -20°C

UNC-0642 Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC-0642 Suppliers

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1481677-78-4, UNC-0642Related Search:

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UNC 0642

UNC0642

UNC-0642

2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

UNC0642, 2-(4,4-Difluoro-1-piperidinyl)-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine

2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine

2-(4,4-Difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine

UNC-0642;UNC0642;UNC 0642

CS-1714

4-Quinazolinamine, 2-(4,4-difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-

UNC0642,inhibit,Inhibitor,Histone Methyltransferase

1481677-78-4

C29H44F2N6O2